Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Markus, Brüll"'
Publikováno v:
Cells, Vol 13, Iss 3, p 242 (2024)
Few models allow the study of neurite damage in the human central nervous system. We used here dopaminergic LUHMES neurons to establish a culture system that allows for (i) the observation of highly enriched neurites, (ii) the preparation of the neur
Externí odkaz:
https://doaj.org/article/79a3448eeae84363b656466a78793a35
Publikováno v:
Cells, Vol 11, Iss 17, p 2644 (2022)
Astrocytes (ACs) do not only play a role in normal neurogenesis and brain homeostasis, but also in inflammatory and neurodevelopmental disorders. We studied here the different patterns of inflammatory activation triggered by cytokines in human induce
Externí odkaz:
https://doaj.org/article/5a260610895944e7b72d2ba6aa3307b9
Autor:
Anna-Sophie Spreng, Marcel Leist, Markus Brüll, Tjalda Falt, Jens Christian Schwamborn, Christiaan Karreman, Ilinca Suciu, Tanja Waldmann, Stefanie Klima
Publikováno v:
Archives of Toxicology
Methods to assess neuronal receptor functions are needed in toxicology and for drug development. Human-based test systems that allow studies on glutamate signalling are still scarce. To address this issue, we developed and characterized pluripotent s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a4e64da1b03ad3e774d6c3f01a2e78
https://doi.org/10.1007/s00204-021-03024-0
https://doi.org/10.1007/s00204-021-03024-0
Autor:
Dominik Loser, Timm Danker, Clemens Möller, Markus Brüll, Jonathan Blum, Anna Forsby, Maria G. Hinojosa, Ylva Johansson, Udo Kraushaar, Ilinca Suciu, Iain Gardner, Gerhard F. Ecker, Karin Grillberger, Jasmin Schaefer, Marcel Leist, Susanne Hougaard Bennekou
Publikováno v:
Loser, D, Hinojosa, M G, Blum, J, Schaefer, J, Brüll, M, Johansson, Y, Suciu, I, Grillberger, K, Danker, T, Möller, C, Gardner, I, Ecker, G F, Bennekou, S H, Forsby, A, Kraushaar, U & Leist, M 2021, ' Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons ', Archives of Toxicology, vol. 95, pp. 2081–2107 . https://doi.org/10.1007/s00204-021-03031-1
Archives of Toxicology
Archives of Toxicology
Neonicotinoid pesticides, originally developed to target the insect nervous system, have been reported to interact with human receptors and to activate rodent neurons. Therefore, we evaluated in how far these compounds may trigger signaling in human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::637d24dda1e3a374f3fd40abcf58d2b1
https://orbit.dtu.dk/en/publications/fb84aa7a-e600-436e-b76d-3a0e4345e020
https://orbit.dtu.dk/en/publications/fb84aa7a-e600-436e-b76d-3a0e4345e020
Autor:
Markus, Brüll, Anna-Sophie, Spreng, Simon, Gutbier, Dominik, Loser, Alice, Krebs, Marvin, Reich, Udo, Kraushaar, Markus, Britschgi, Christoph, Patsch, Marcel, Leist
Human cell-based neural organoids are increasingly being used for investigations of neurotoxicity, and to study the pathophysiology of neurodegenerative diseases. Here, we present a fast and robust method to generate 3D cultured human dopaminergic ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::01ac97d6e69ca379880f4c11ef6a9b2d
Autor:
Marcel Leist, Simon Gutbier, Joanna L. Elson, Liam Pearson, David Dickens, Véronique Hubscher-Bruder, David Tetard, Stefan Schildknecht, Sotiris Kyriakou, Frank W. Lewis, Jérémy Brandel, Sylvia Michel, Anna Katharina Ückert, Ilse S. Pienaar, Markus Brüll
Publikováno v:
Archives of Toxicology
Archives of Toxicology, Springer Verlag, 2020, ⟨10.1007/s00204-020-02826-y⟩
Archives of Toxicology, Springer Verlag, 2020, ⟨10.1007/s00204-020-02826-y⟩
While the etiology of non-familial Parkinson’s disease (PD) remains unclear, there is evidence that increased levels of tissue iron may be a contributing factor. Moreover, exposure to some environmental toxicants is considered an additional risk fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f77013f90544b89b21674f09ba07ba
https://hal.archives-ouvertes.fr/hal-02905604
https://hal.archives-ouvertes.fr/hal-02905604
Autor:
Markus Brüll, Timm Danker, Ilinca Suciu, Marcel Leist, Stefanie Klima, Clemens Möller, Jasmin Schaefer, Dominik Loser, Udo Kraushaar, Anna-Katharina Ückert
Publikováno v:
Archives of Toxicology
Prediction of drug toxicity on the human nervous system still relies mainly on animal experiments. Here, we developed an alternative system allowing assessment of complex signaling in both individual human neurons and on the network level. The LUHMES
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::748d4056c50b6de2fb81443f7464ef1b
Autor:
Markus Brüll
Publikováno v:
ALTEX.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::418256fd83502bdcf493191c52fda158
https://doi.org/10.14573/altex.1911111s1
https://doi.org/10.14573/altex.1911111s1