Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Markus, Bitzer"'
Autor:
Joonsang Lee, Elisa Warner, Salma Shaikhouni, Markus Bitzer, Matthias Kretzler, Debbie Gipson, Subramaniam Pennathur, Keith Bellovich, Zeenat Bhat, Crystal Gadegbeku, Susan Massengill, Kalyani Perumal, Jharna Saha, Yingbao Yang, Jinghui Luo, Xin Zhang, Laura Mariani, Jeffrey B. Hodgin, Arvind Rao
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Machine learning applied to digital pathology has been increasingly used to assess kidney function and diagnose the underlying cause of chronic kidney disease (CKD). We developed a novel computational framework, clustering-based spatial anal
Externí odkaz:
https://doaj.org/article/0eec12b4c60846b9b414230ba0f4f3e6
Autor:
Linda Wang, Bayle Smith-Salzberg, Kevin EC Meyers, Dorey A. Glenn, Katherine R. Tuttle, Vimal K. Derebail, Tammy M. Brady, Keisha Gibson, Abigail R. Smith, Michelle M. O’Shaughnessy, Tarak Srivastava, Gentzon Hall, Jarcy Zee, Markus Bitzer, Christine B. Sethna
Publikováno v:
BMC Nephrology, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Background Tobacco exposure has been recognized as a risk factor for cardiovascular disease (CVD) and progression of kidney disease. Patients with proteinuric glomerulopathies are at increased risk for cardiovascular morbidity and mortality.
Externí odkaz:
https://doaj.org/article/5abe55563fbc42c09f55acec204d5aac
Autor:
Dennis G. Moledina, Wassim Obeid, Rex N. Smith, Ivy Rosales, Meghan E. Sise, Gilbert Moeckel, Michael Kashgarian, Michael Kuperman, Kirk N. Campbell, Sean Lefferts, Kristin Meliambro, Markus Bitzer, Mark A. Perazella, Randy L. Luciano, Jordan S. Pober, Lloyd G. Cantley, Robert B. Colvin, F. Perry Wilson, Chirag R. Parikh
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 13 (2023)
Background Acute tubulointerstitial nephritis (AIN) is one of the few causes of acute kidney injury with diagnosis-specific treatment options. However, due to the need to obtain a kidney biopsy for histological confirmation, AIN diagnosis can be dela
Externí odkaz:
https://doaj.org/article/8efe2f2685704f25a2ece87934b2792f
Autor:
Baohai Shao, Farsad Afshinnia, Anna V. Mathew, Graziella E. Ronsein, Carissa Thornock, Angela D. Irwin, Mayank Kansal, Panduranga S. Rao, Mirela Dobre, Sadeer Al-Kindi, Matthew R. Weir, Alan Go, Jiang He, Jing Chen, Harold Feldman, Karin E. Bornfeldt, Subramaniam Pennathur, Matthias Kretzler, Debbie Gipson, Markus Bitzer, Crystal Gadegbeku, Keith Bellovich, Zeenat Bhat, Susan Massengill, Kalyani Perumal, Lawrence J. Appel, Debbie L. Cohen, James P. Lash, Robert G. Nelson, Mahboob Rahman, Vallabh O. Shah, Mark L. Unruh
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 6, Pp 100381- (2023)
Patients with chronic kidney disease (CKD) are at high risk for CVD. However, traditional CVD risk factors cannot completely explain the increased risk. Altered HDL proteome is linked with incident CVD in CKD patients, but it is unclear whether other
Externí odkaz:
https://doaj.org/article/51bb7f209b9345f2821df3f6e9b94938
Autor:
Jennifer A. Schaub, Fadhl M. AlAkwaa, Phillip J. McCown, Abhijit S. Naik, Viji Nair, Sean Eddy, Rajasree Menon, Edgar A. Otto, Dawit Demeke, John Hartman, Damian Fermin, Christopher L. O’Connor, Lalita Subramanian, Markus Bitzer, Roger Harned, Patricia Ladd, Laura Pyle, Subramaniam Pennathur, Ken Inoki, Jeffrey B. Hodgin, Frank C. Brosius III, Robert G. Nelson, Matthias Kretzler, Petter Bjornstad
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 5 (2023)
The molecular mechanisms of sodium-glucose cotransporter-2 (SGLT2) inhibitors (SGLT2i) remain incompletely understood. Single-cell RNA sequencing and morphometric data were collected from research kidney biopsies donated by young persons with type 2
Externí odkaz:
https://doaj.org/article/786e05c40b544ed683f2bef88a499a82
Autor:
Joonsang Lee, Elisa Warner, Salma Shaikhouni, Markus Bitzer, Matthias Kretzler, Debbie Gipson, Subramaniam Pennathur, Keith Bellovich, Zeenat Bhat, Crystal Gadegbeku, Susan Massengill, Kalyani Perumal, Jharna Saha, Yingbao Yang, Jinghui Luo, Xin Zhang, Laura Mariani, Jeffrey B. Hodgin, Arvind Rao, the C-PROBE Study
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Pathologists use visual classification to assess patient kidney biopsy samples when diagnosing the underlying cause of kidney disease. However, the assessment is qualitative, or semi-quantitative at best, and reproducibility is challenging.
Externí odkaz:
https://doaj.org/article/fe2e0a13ca2544f7bdcbdd8b50cb682f
Autor:
Abhijit S. Naik, Su Q. Wang, Mahboob Chowdhury, Jawad Aqeel, Christopher L. O’Connor, Jocelyn E. Wiggins, Markus Bitzer, Roger C. Wiggins
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Increasing evidence suggests that single in kidney states (e.g., kidney transplantation and living donation) progressive glomerulosclerosis limits kidney lifespan. Modeling shows that post-nephrectomy compensatory glomerular volume (GV) incr
Externí odkaz:
https://doaj.org/article/64cee3c1b04e483891ea2275a2fe847c
Autor:
Jeffrey W. Pippin, Natalya Kaverina, Yuliang Wang, Diana G. Eng, Yuting Zeng, Uyen Tran, Carol J. Loretz, Anthony Chang, Shreeram Akilesh, Chetan Poudel, Hannah S. Perry, Christopher O’Connor, Joshua C. Vaughan, Markus Bitzer, Oliver Wessely, Stuart J. Shankland
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 16 (2022)
With an aging population, kidney health becomes an important medical and socioeconomic factor. Kidney aging mechanisms are not well understood. We previously showed that podocytes isolated from aged mice exhibit increased expression of programmed cel
Externí odkaz:
https://doaj.org/article/6f35f7a0c54e416aa558e94eded1b8d9
Autor:
Hongyang Li, Ridvan Eksi, Daiyao Yi, Bradley Godfrey, Lisa R. Mathew, Christopher L. O’Connor, Markus Bitzer, Matthias Kretzler, Rajasree Menon, Yuanfang Guan
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 4 (2022)
Studying isoform expression at the microscopic level has always been a challenging task. A classical example is kidney, where glomerular and tubulo-interstitial compartments carry out drastically different physiological functions and thus presumably
Externí odkaz:
https://doaj.org/article/b932298f7f1d4d098df85d021514e4c1
Autor:
Baohai Shao, Anna V. Mathew, Carissa Thornock, Subramaniam Pennathur, Matthias Kretzler, Debbie Gipson, Markus Bitzer, Crystal Gadegbeku, Keith Bellovich, Zeenat Bhat, Susan Massengill, Kalyani Perumal
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100135- (2021)
Patients with chronic kidney disease (CKD) are at high risk for CVD. However, traditional lipid risk factors, including low HDL levels, cannot completely explain the increased risk. Altered HDL proteome is linked with both CVD and CKD, but the role o
Externí odkaz:
https://doaj.org/article/b4aa4d551b3048118677416168a82eca