Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis

Autor: Miles, Luke A., Hermans, Stefan J., Crespi, Gabriela A.N., Gooi, Jonathan H., Doughty, Larissa, Nero, Tracy L., Markulić, Jasmina, Ebneth, Andreas, Wroblowski, Berthold, Oehlrich, Daniel, Trabanco, Andrés A., Rives, Marie-Laure, Royaux, Ines, Hancock, Nancy C., Parker, Michael W.

Publikováno v: In iScience 27 September 2019 19:110-118

Structural biology of cell surface receptors implicated in Alzheimer's disease.

Autor: Hermans SJ; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010 Australia.; Structural Biology, St. Vincent's Institute of Medical Research, 9 Princes Street, Victoria 3065 Fitzroy, Australia., Nero TL; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010 Australia., Morton CJ; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010 Australia., Gooi JH; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010 Australia.; Structural Biology, St. Vincent's Institute of Medical Research, 9 Princes Street, Victoria 3065 Fitzroy, Australia., Crespi GAN; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010 Australia.; Structural Biology, St. Vincent's Institute of Medical Research, 9 Princes Street, Victoria 3065 Fitzroy, Australia., Hancock NC; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010 Australia.; Structural Biology, St. Vincent's Institute of Medical Research, 9 Princes Street, Victoria 3065 Fitzroy, Australia., Gao C; Structural Biology, St. Vincent's Institute of Medical Research, 9 Princes Street, Victoria 3065 Fitzroy, Australia.; Present Address: Wren Therapeutics Ltd., Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW UK., Ishii K; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010 Australia.; Structural Biology, St. Vincent's Institute of Medical Research, 9 Princes Street, Victoria 3065 Fitzroy, Australia., Markulić J; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010 Australia.; Structural Biology, St. Vincent's Institute of Medical Research, 9 Princes Street, Victoria 3065 Fitzroy, Australia., Parker MW; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010 Australia.; Structural Biology, St. Vincent's Institute of Medical Research, 9 Princes Street, Victoria 3065 Fitzroy, Australia.

Publikováno v: Biophysical reviews [Biophys Rev] 2021 Nov 18; Vol. 14 (1), pp. 233-255. Date of Electronic Publication: 2021 Nov 18 (Print Publication: 2022).