Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death.

Autor: Taft J; Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Markson M; Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Legarda D; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Patel R; Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Chan M; Department of Immunology, Mayo Clinic, Rochester, MN, 55905, USA., Malle L; Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Richardson A; Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Gruber C; Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Martín-Fernández M; Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Mancini GMS; Department of Clinical Genetics, Erasmus University Medical Center, 3015GD Rotterdam, the Netherlands., van Laar JAM; Department of Immunology, Erasmus University Medical Center, 3015GD Rotterdam, the Netherlands., van Pelt P; Department of Rheumatology, Erasmus University Medical Center, 3015GD Rotterdam, the Netherlands., Buta S; Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Wokke BHA; Department of Neurology, Erasmus University Medical Center, 3015GD Rotterdam, the Netherlands., Sabli IKD; Department of Paediatric Infectious Diseases and Virology, Imperial College London, London, UK; Centre for Paediatrics and Child Health, Faculty of Medicine, Imperial College London, London, UK., Sancho-Shimizu V; Department of Paediatric Infectious Diseases and Virology, Imperial College London, London, UK; Centre for Paediatrics and Child Health, Faculty of Medicine, Imperial College London, London, UK., Chavan PP; Inflammatory Disease Section, National Human Genome Research Institute, Bethesda, MD, 20892, USA; Pediatric Rheumatology, SRCC Children's Hospital, Mumbai, India., Schnappauf O; Inflammatory Disease Section, National Human Genome Research Institute, Bethesda, MD, 20892, USA., Khubchandani R; Pediatric Rheumatology, SRCC Children's Hospital, Mumbai, India; Consultant Pediatrician, Jaslok and Breach Candy Hospitals, Mumbai, India., Cüceoğlu MK; Department of Pediatric Rheumatology, Hacettepe University, Ankara, Turkey., Özen S; Department of Pediatric Rheumatology, Hacettepe University, Ankara, Turkey., Kastner DL; Inflammatory Disease Section, National Human Genome Research Institute, Bethesda, MD, 20892, USA., Ting AT; Department of Immunology, Mayo Clinic, Rochester, MN, 55905, USA., Aksentijevich I; Inflammatory Disease Section, National Human Genome Research Institute, Bethesda, MD, 20892, USA., Hollink IHIM; Department of Clinical Genetics, Erasmus University Medical Center, 3015GD Rotterdam, the Netherlands., Bogunovic D; Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. Electronic address: dusan.bogunovic@mssm.edu.

Publikováno v: Cell [Cell] 2021 Aug 19; Vol. 184 (17), pp. 4447-4463.e20. Date of Electronic Publication: 2021 Aug 06.

N -quinoline-benzenesulfonamide derivatives exert potent anti-lymphoma effect by targeting NF-κB.

Autor: Kalac M; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Center for Lymphoid Malignancies, Columbia University Irving Medical Center, New York, NY, USA.; Department of Hematology and Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA., Mangone M; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Center for Lymphoid Malignancies, Columbia University Irving Medical Center, New York, NY, USA., Rinderspacher A; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Department of Nephrology, Columbia University Irving Medical Center, New York, NY, USA., Deng SX; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Department of Nephrology, Columbia University Irving Medical Center, New York, NY, USA., Scotto L; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Center for Lymphoid Malignancies, Columbia University Irving Medical Center, New York, NY, USA., Markson M; Department of Hematology and Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA., Bansal M; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Psychogenics Inc., Paramus, NJ, USA.; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA., Califano A; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Biomedical Informatics, Columbia University, New York, NY, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.; J.P. Sulzberger Columbia Genome Center, New York, NY, USA., Landry DW; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Department of Nephrology, Columbia University Irving Medical Center, New York, NY, USA., O'Connor OA; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Center for Lymphoid Malignancies, Columbia University Irving Medical Center, New York, NY, USA.; Division of Hematology and Oncology, University of Virginia Cancer Center, Charlottesville, VA, USA.

Publikováno v: IScience [iScience] 2020 Nov 30; Vol. 23 (12), pp. 101884. Date of Electronic Publication: 2020 Nov 30 (Print Publication: 2020).

TBK1 and Caspase-8 suppress necroptosis but activate NLRP3 inflammasome activation during CXCL4 and TLR8 costimulation.

Autor: Cui Y; Department of Blood Transfusion, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaan Xi, China., Zhang Y; Med-X Institute, Center for Immunological and Metabolic Diseases, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, China., Yang C; Department of Blood Transfusion, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaan Xi, China. ychmax@xjtufh.edu.cn.; Med-X Institute, Center for Immunological and Metabolic Diseases, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, China. ychmax@xjtufh.edu.cn.

Publikováno v: Cell death discovery [Cell Death Discov] 2024 Dec 23; Vol. 10 (1), pp. 511. Date of Electronic Publication: 2024 Dec 23.

Single‐cell landscape of the cellular microenvironment in three different colonic polyp subtypes in children.

Autor: Deng, Yafei^1,2 (AUTHOR), Li, Canlin³ (AUTHOR), Huang, Lanlan^1,2 (AUTHOR), Xiong, Peiwen¹ (AUTHOR), Li, Yana¹ (AUTHOR), Liu, Yongjie¹ (AUTHOR), Li, Songyang¹ (AUTHOR), Chen, Weijian⁴ (AUTHOR), Yin, Qiang⁵ (AUTHOR), Li, Yong⁵ (AUTHOR), Yang, Qinglan¹ (AUTHOR), Peng, Hongyan¹ (AUTHOR), Wu, Shuting¹ (AUTHOR), Wang, Xiangyu¹ (AUTHOR), Tong, Qin^2,3 (AUTHOR), Ouyang, Hongjuan³ (AUTHOR), Hu, Die⁶ (AUTHOR), Liu, Xinjia^1,2 (AUTHOR), Li, Liping¹ (AUTHOR), You, Jieyu³ (AUTHOR)

Publikováno v: Clinical & Translational Medicine. Jan2024, Vol. 14 Issue 1, p1-21. 21p.

The Potential of Cylindromatosis (CYLD) as a Therapeutic Target in Oxidative Stress-Associated Pathologies: A Comprehensive Evaluation.

Autor: Huang, Zhenzhou¹ (AUTHOR) huangzhenzhou97@163.com, Tan, Yanjie¹ (AUTHOR) 620036@sdnu.edu.cn

Publikováno v: International Journal of Molecular Sciences. May2023, Vol. 24 Issue 9, p8368. 17p.