Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Markos Koutmos"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Methylenetetrahydrofolate reductase (MTHFR) is a pivotal flavoprotein connecting the folate and methionine methyl cycles, catalyzing the conversion of methylenetetrahydrofolate to methyltetrahydrofolate. Human MTHFR (hMTHFR) undergoes elabor
Externí odkaz:
https://doaj.org/article/bf7b48484977496d8dd687e9bf7f703f
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Cobalamin-dependent methionine synthase (MS) is a key enzyme in methionine and folate one-carbon metabolism. MS is a large multi-domain protein capable of binding and activating three substrates: homocysteine, folate, and S-adenosylmethionin
Externí odkaz:
https://doaj.org/article/59bd14e459bd47c8bd29ec30eff74887
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 735 (2024)
Antibiotic resistance remains a pressing global concern, with most antibiotics targeting the bacterial ribosome or a limited range of proteins. One class of underexplored antibiotic targets is bacterial riboswitches, structured RNA elements that regu
Externí odkaz:
https://doaj.org/article/d12ddd51e3d24efbb5985c481d336055
Autor:
Radhika S Ganu, Yasuko Ishida, Markos Koutmos, Sergios-Orestis Kolokotronis, Alfred L Roca, Timothy A Garrow, Lawrence B Schook
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0134084 (2015)
Betaine-homocysteine S-methyltransferase (BHMT) and BHMT2 convert homocysteine to methionine using betaine and S-methylmethionine, respectively, as methyl donor substrates. Increased levels of homocysteine in blood are associated with cardiovascular
Externí odkaz:
https://doaj.org/article/7777aaee29a94f86b4d4ef3fab61ef9d
The first step in transfer RNA (tRNA) maturation is the cleavage of the 5’ end of precursor transfer RNA (pre-tRNA) catalyzed by ribonuclease P (RNase P). RNase P is either a ribonucleoprotein (RNP) complex with a catalytic RNA subunit or aprotein-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8cd1aba9dec374a3660dfc93f3b2322
https://doi.org/10.1101/2022.10.20.512141
https://doi.org/10.1101/2022.10.20.512141
Publikováno v:
Methods in enzymology. 668
Antivitamins B
Publikováno v:
Journal of Biological Chemistry. 299:102855
The flavoprotein methylenetetrahydrofolate reductase (MTHFR) catalyzes the reduction of N5, N10-methylenetetrahydrofolate (CH
Publikováno v:
RNA. 27:420-432
Mitochondrial diseases linked to mutations in mitochondrial (mt) tRNA sequences are common. However, the contributions of these tRNA mutations to the development of diseases is mostly unknown. Mutations may affect interactions with (mt)tRNA maturatio
Autor:
Meredith K. Purchal, Daniel E. Eyler, Mehmet Tardu, Monika K. Franco, Megan M. Korn, Taslima Khan, Ryan McNassor, Rachel Giles, Katherine Lev, Hari Sharma, Jeremy Monroe, Leena Mallik, Markos Koutmos, Kristin S. Koutmou
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Pseudouridine is among the most-abundant RNA modifications. We present a framework for conceptualizing how eukaryotic pseudouridine synthases select their substrates. This work reveals the structure of yeast pseudouridine synthase 7 (Pus
Publikováno v:
Methods in Enzymology ISBN: 9780323915915
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca198c88847fcf797875195691114bfb
https://doi.org/10.1016/bs.mie.2021.12.016
https://doi.org/10.1016/bs.mie.2021.12.016