Výsledky vyhledávání - "Marko Sysi‐Aho"

Akademický článek

RNA-Seq and Mass-Spectrometry-Based Lipidomics Reveal Extensive Changes of Glycerolipid Pathways in Brown Adipose Tissue in Response to Cold

Autor: Ann-Britt Marcher, Anne Loft, Ronni Nielsen, Terhi Vihervaara, Jesper Grud Skat Madsen, Marko Sysi-Aho, Kim Ekroos, Susanne Mandrup

Publikováno v: Cell Reports, Vol 13, Iss 9, Pp 2000-2013 (2015)

Cold exposure greatly alters brown adipose tissue (BAT) gene expression and metabolism to increase thermogenic capacity. Here, we used RNA sequencing and mass-spectrometry-based lipidomics to provide a comprehensive resource describing the molecular

Externí odkaz: https://doaj.org/article/e749a7d550da4a318785f7f55d4b5e07

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Akademický článek

Gender‐dependent progression of systemic metabolic states in early childhood

Autor: Janne Nikkilä, Marko Sysi‐Aho, Andrey Ermolov, Tuulikki Seppänen‐Laakso, Olli Simell, Samuel Kaski, Matej Orešič

Publikováno v: Molecular Systems Biology, Vol 4, Iss 1, Pp 1-7 (2008)

Abstract Little is known about the human intra‐individual metabolic profile changes over an extended period of time. Here, we introduce a novel concept suggesting that children even at a very young age can be categorized in terms of metabolic state

Externí odkaz: https://doaj.org/article/5d9e871e0446433c838e9a99754b94b9

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Akademický článek

Integrated model of metabolism and autoimmune response in β-cell death and progression to type 1 diabetes.

Autor: Tijana Marinković, Marko Sysi-Aho, Matej Orešič

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e51909 (2012)

Progression to type 1 diabetes is characterized by complex interactions of environmental, metabolic and immune system factors, involving both degenerative pathways leading to loss of pancreatic β-cells as well as protective pathways. The interplay b

Externí odkaz: https://doaj.org/article/af53fb7f767746ff80bc2fcb7f1ee51e

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Akademický článek

Metabolic regulation in progression to autoimmune diabetes.

Publikováno v: PLoS Computational Biology, Vol 7, Iss 10, p e1002257 (2011)

Recent evidence from serum metabolomics indicates that specific metabolic disturbances precede β-cell autoimmunity in humans and can be used to identify those children who subsequently progress to type 1 diabetes. The mechanisms behind these disturb

Externí odkaz: https://doaj.org/article/efa2394923bf45da8529c7eec04cc069

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Akademický článek

Serum lipidomics meets cardiac magnetic resonance imaging: profiling of subjects at risk of dilated cardiomyopathy.

Autor: Marko Sysi-Aho, Juha Koikkalainen, Tuulikki Seppänen-Laakso, Maija Kaartinen, Johanna Kuusisto, Keijo Peuhkurinen, Satu Kärkkäinen, Margareta Antila, Kirsi Lauerma, Eeva Reissell, Raija Jurkko, Jyrki Lötjönen, Tiina Heliö, Matej Orešič

Publikováno v: PLoS ONE, Vol 6, Iss 1, p e15744 (2011)

Dilated cardiomyopathy (DCM), characterized by left ventricular dilatation and systolic dysfunction, constitutes a significant cause for heart failure, sudden cardiac death or need for heart transplantation. Lamin A/C gene (LMNA) on chromosome 1p12 i

Externí odkaz: https://doaj.org/article/268eb6061f0948ca9461ace159bd6b9f

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Akademický článek

Acquired obesity is associated with changes in the serum lipidomic profile independent of genetic effects--a monozygotic twin study.

Autor: Kirsi H Pietiläinen, Marko Sysi-Aho, Aila Rissanen, Tuulikki Seppänen-Laakso, Hannele Yki-Järvinen, Jaakko Kaprio, Matej Oresic

Publikováno v: PLoS ONE, Vol 2, Iss 2, p e218 (2007)

Both genetic and environmental factors are involved in the etiology of obesity and the associated lipid disturbances. We determined whether acquired obesity is associated with changes in global serum lipid profiles independent of genetic factors in y

Externí odkaz: https://doaj.org/article/391d52eeadb94f528dd8805a23457cea

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