Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Marko Oblak"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:958-962
Cyclothialidines are a class of bacterial DNA gyrase B (GyrB) subunit inhibitors, targeting its ATP-binding site. Starting from the available structural information on cyclothialidine GR122222X (2), an in silico virtual screening campaign was designe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483301c9cffdf7feeadd5d12f7bd44ff
https://doi.org/10.1016/j.bmcl.2009.12.060
https://doi.org/10.1016/j.bmcl.2009.12.060
Publikováno v:
Current Medicinal Chemistry. 14:2033-2047
DNA gyrase is an attractive and well established target for the development of antibacterial agents. This bacterial enzyme, whose biological function is to control the topological state of DNA molecules, consists of two catalytic subunits; GyrA is re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44dfae4fecc4a46b1bf97b0e9dfb60e4
https://doi.org/10.2174/092986707781368414
https://doi.org/10.2174/092986707781368414
Autor:
Uroš Urleb, Andréa Dessen, Mireille Hervé, Stanislav Gobec, Katja Kristan, Jan Humljan, Carlos Contreras-Martel, Miha Kotnik, Tom Solmajer, Didier Blanot, Marko Oblak
Publikováno v:
Journal of Molecular Biology. 370:107-115
Mur ligases play an essential role in the intracellular biosynthesis of bacterial peptidoglycan, the main component of the bacterial cell wall, and represent attractive targets for the design of novel antibacterials. UDP-N-acetylmuramoyl-L-alanine:D-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ba10cc02e8d5abb1ad10ffb66a5a0d
https://doi.org/10.1016/j.jmb.2007.04.048
https://doi.org/10.1016/j.jmb.2007.04.048
Autor:
Aleš Obreza, Marko Oblak, Gorazd Drevenšek, Manica Cerne, Anamarija Zega, Luka Peternel, Mateja Stempelj, Metka V. Budihna, Lovro Stanovnik, Uroš Urleb
Publikováno v:
Thrombosis and Haemostasis. 95:294-300
SummaryThe main structural feature of direct thrombin inhibitor LK-732 responsible for the appropriate interaction at the thrombin active site is a strong basic group. A possibility that a strong basic group of LK-732 might contribute to the mast cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d16693f67331ee15cf5d8d424110cfd9
https://doi.org/10.1160/th05-10-0683
https://doi.org/10.1160/th05-10-0683
Publikováno v:
QSAR & Combinatorial Science. 23:399-405
Quantitative structure-activity relationship (QSAR) studies on a set of Streptococcus pneumoniae MurD transition-state inhibitors were performed, using a comprehensive set of molecular descriptors calculated by CODESSA software. Multiple and best mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6a493fc2c2d058ac7720ea02f0479f8
https://doi.org/10.1002/qsar.200430875
https://doi.org/10.1002/qsar.200430875
Publikováno v:
Journal of Chemical Information and Computer Sciences. 40:994-1001
Quantitative structure-activity relationship (QSAR) studies on 104 flavonoid derivatives as p56lck protein tyrosine kinase (PTK) inhibitors were performed, using a large number of molecular descriptors calculated by CODESSA software. Multiple linear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a492f4683f064b084f21abc5f01ec9c
https://doi.org/10.1021/ci000001a
https://doi.org/10.1021/ci000001a
Autor:
Uroš Urleb, Anton Meden, Jurij Svete, Marko Oblak, Uroš Grošelj, Petra Stefanic Anderluh, Jure Bezenšek, Branko Stanovnik
Publikováno v:
ChemInform. 39
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::733d19edea92eeaba75e1e4c11055f53
https://doi.org/10.1002/chin.200841160
https://doi.org/10.1002/chin.200841160
Autor:
Darko Kocjan, Miha Andrejašič, Tom Solmajer, Tomaz Mesar, Andrej Kocijan, Petra Stefanic Anderluh, Dušan Turk, Mateja Vilar, Lovro Selic, Tadeja Prevec, Anton Copar, Andrej Prezelj, Gregor Vilfan, Uroš Urleb, Marko Oblak, Lars Hesse, Ivan Plantan
Publikováno v:
Journal of medicinal chemistry. 50(17)
A wide variety of pathogens have acquired antimicrobial resistance as an inevitable evolutionary response to the extensive use of antibacterial agents. In particular, one of the most widely used antibiotic structural classes is the beta-lactams, in w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0558f49387f0a2db24d2c10cda9b7dcb
https://pubmed.ncbi.nlm.nih.gov/17665896
https://pubmed.ncbi.nlm.nih.gov/17665896
Autor:
Simona Golic Grdadolnik, Tom Solmajer, Dominique Desplancq, R. Andrew Atkinson, Arnaud Poterszman, Marko Oblak, Dino Moras, Hélène Nierengarten, Miha Kotnik
Publikováno v:
Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, Elsevier, 2006, 349 (4), pp.1206-13. ⟨10.1016/j.bbrc.2006.08.172⟩
Biochemical and Biophysical Research Communications, Elsevier, 2006, 349 (4), pp.1206-13. ⟨10.1016/j.bbrc.2006.08.172⟩
International audience; Fighting bacterial resistance is a challenging task in the field of medicinal chemistry. DNA gyrase represents a validated antibacterial target and has drawn much interest in recent years. By a structure-based approach we have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad2505f9ded190966f540de2b51adcb5
https://hal.archives-ouvertes.fr/hal-00188088
https://hal.archives-ouvertes.fr/hal-00188088
Publikováno v:
Journal of molecular modeling. 13(1)
The high incidence of thrombembolic diseases justifies the development of new antithrombotics. The search for a direct inhibitor has resulted in the synthesis of a considerable number of low molecular weight molecules that inhibit human alpha-thrombi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e31fd2f4b87569151a162b0a59c412d4
https://pubmed.ncbi.nlm.nih.gov/17013633
https://pubmed.ncbi.nlm.nih.gov/17013633