Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Marko Janke"'
Autor:
Katrin Neumann, Derk Amsen, Alexander Scheffold, Christian Neumann, Marko Janke, Christine Rudolph
Publikováno v:
European Journal of Immunology. 45:2008-2016
Under homeostasis, liver sinusoidal endothelial cells (LSECs) shift intrahepatic T-cell responses towards tolerance. However, the role of LSECs in the regulation of T-cell-induced liver inflammation is less clear. Here, we studied the capacity of LSE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4ec9099a82d1de6df852083af59e1e0
https://doi.org/10.1002/eji.201445346
https://doi.org/10.1002/eji.201445346
Autor:
Alexander Scheffold, Markus M. Heimesaat, Anja A. Kühl, Marko Janke, Katrin Neumann, Frederik Heinrich, Christine Rudolph, Christian Neumann, Jonas Ahlers, Victoria Junghans, Andreas Radbruch, Mir-Farzin Mashreghi, Nadine Mockel-Tenbrinck, Sin-Hyeog Im, Sascha Rutz, Charlotte Esser
Publikováno v:
The Journal of Experimental Medicine
The transcriptional regulator Blimp-1 is absolutely required for IL-10 production in Th1 cells and limits inflammatory effector T cell responses downstream of IL-12 and IL-27.
Secretion of the immunosuppressive cytokine interleukin (IL) 10 by ef
Secretion of the immunosuppressive cytokine interleukin (IL) 10 by ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ac4091fb83195214ba741ca015125b
https://doi.org/10.1084/jem.20131548
https://doi.org/10.1084/jem.20131548
Publikováno v:
European Journal of Immunology. 40:1089-1098
Recently, IL-17 produced by Th17 cells was described as pro-inflammatory cytokine with an eminent role in autoimmune diseases, e.g. rheumatoid arthritis. A lack of IL-17 leads to amelioration of collagen-induced arthritis. IL-17 induction in naive CD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b43bd099a69632448beeb1d7a7c95b9
https://doi.org/10.1002/eji.200939487
https://doi.org/10.1002/eji.200939487
Publikováno v:
Zeitschrift für Rheumatologie. 67:684-688
State-of-the-art immunosuppressive therapies, though efficient in the treatment of rheumatic inflammatory disorders, in most cases do not provide a cure. Complete immunablation and the associated deletion of the reactive immunological memory followed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cb8e2a3873c05f21a687956f3f7ec7e
https://doi.org/10.1007/s00393-008-0403-5
https://doi.org/10.1007/s00393-008-0403-5
Autor:
Alexander Scheffold, Thomas Häupl, Ahmed N. Hegazy, Orhan Aktas, J. Sieper, Michal Janitz, Stephan Kreher, Philipp Enghard, Sina Bartfeld, Cornelia Doebis, Alf Hamann, Juliana Koeck, Inna Gitelman, Marko Janke, Katharina Eulenburg, Gerd R Burmester, Martin Zeitz, Ria Baumgrass, Frauke Zipp, Thomas Kamradt, Rainer Duchmann, Joachim Gruen, Jens Y Humrich, Ulf Schulze-Topphoff, Martin Rudwaleit, Veit Krenn, Daniel C. Baumgart, Kerstin Bonhagen, Christoph Loddenkemper, Uwe Niesner, Max Löhning, Maria H. Lexberg, Bertram Wiedenmann, Inka Albrecht, Hyun D. Chang, Helena Radbruch, Andreas Radbruch, Sascha Rutz
Publikováno v:
The Journal of Experimental Medicine
The basic helix-loop-helix transcriptional repressor twist1, as an antagonist of nuclear factor kappaB (NF-kappaB)-dependent cytokine expression, is involved in the regulation of inflammation-induced immunopathology. We show that twist1 is expressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643918547059488ea1c9f5b3f2630ad5
http://europepmc.org/articles/PMC2525589
http://europepmc.org/articles/PMC2525589
Autor:
Katrin, Neumann, Christine, Rudolph, Christian, Neumann, Marko, Janke, Derk, Amsen, Alexander, Scheffold
Publikováno v:
European journal of immunology. 45(7)
Under homeostasis, liver sinusoidal endothelial cells (LSECs) shift intrahepatic T-cell responses towards tolerance. However, the role of LSECs in the regulation of T-cell-induced liver inflammation is less clear. Here, we studied the capacity of LSE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2155c8890a4b26057ffb82a22caa1c96
https://pubmed.ncbi.nlm.nih.gov/25884798
https://pubmed.ncbi.nlm.nih.gov/25884798
Autor:
Anja A. Kühl, Jonathan A. Epstein, Uwe Niesner, Maria H. Lexberg, Joachim R. Grün, Koji Tokoyoda, Andreas Radbruch, Hyun-Dong Chang, Kristyna Hradilkova, Christoph Loddenkemper, Alf Hamann, Marko Janke, Astrid Menning, Inga Lepenies, Kerstin Westendorf, Inka Albrecht
Publikováno v:
European journal of immunology. 40(11)
Th1 cells are prominent in inflamed tissue, survive conventional immunosuppression, and are believed to play a pivotal role in driving chronic inflammation. Here, we identify homeobox only protein (Hopx) as a critical and selective regulator of the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72ab0987e4c03c2037c7fd9a5e6148f8
https://pubmed.ncbi.nlm.nih.gov/21061432
https://pubmed.ncbi.nlm.nih.gov/21061432
Autor:
Marko, Janke, Michael, Peine, Alexia, Nass, Lars, Morawietz, Alf, Hamann, Alexander, Scheffold
Publikováno v:
European journal of immunology. 40(4)
Recently, IL-17 produced by Th17 cells was described as pro-inflammatory cytokine with an eminent role in autoimmune diseases, e.g. rheumatoid arthritis. A lack of IL-17 leads to amelioration of collagen-induced arthritis. IL-17 induction in naïve C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::52ae64bebdc8d3c615e61e2de70cfeb9
https://pubmed.ncbi.nlm.nih.gov/20101617
https://pubmed.ncbi.nlm.nih.gov/20101617
Autor:
Ulrike Jung, Marko Janke, Thomas Rudel, Alexander Scheffold, Ioanna Andreou, Andrej Mantei, Volker Patzel, Sascha Rutz, Dennis Kirchhoff, Uwe Vogel, Martin Weber
Publikováno v:
European journal of immunology. 38(9)
RNA interference (RNAi)-mediated knockdown of target gene expression represents a powerful approach for functional genomics and therapeutic applications. However, for T lymphocytes, central regulators of immunity and immunopathologies, the applicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c56f7532af33140289dcb4b016c457da
https://pubmed.ncbi.nlm.nih.gov/18792414
https://pubmed.ncbi.nlm.nih.gov/18792414
Autor:
Sascha Rutz, Nadine Kassner, Alexander Scheffold, Thordis Hohnstein, Manuela Krueger, Marko Janke
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 105(9)
T helper 1 (Th1) cells mediate powerful cellular immune responses. However, if unbalanced, Th1 immunity eventually may cause pathology. Recently, it has been shown that IL-10, an antiinflammatory cytokine strongly antagonizing Th1-mediated effects, c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac6fe99c01337d83958cdf3b9660eff
https://pubmed.ncbi.nlm.nih.gov/18292228
https://pubmed.ncbi.nlm.nih.gov/18292228