Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Marko J. Kallio"'
Autor:
Sofia Aakko, Anne Hege Straume, Einar Elvbakken Birkeland, Ping Chen, Xi Qiao, Per Eystein' 'Lønning, Marko J. Kallio
Publikováno v:
Translational Oncology, Vol 12, Iss 1, Pp 170-179 (2019)
Taxanes are chemotherapeutic agents used in the treatment of solid tumors, particularly of breast, ovarian, and lung origin. However, patients show divergent therapy responses, and the molecular determinants of taxane sensitivity have remained elusiv
Externí odkaz:
https://doaj.org/article/882708b2dee8437db0dcdf260e5b1495
Autor:
Marko J, Kallio, Viktoriia, Starokozhko, Eleonora, Agricola, Manja, Burggraf, Anne, Heß, Wolfgang, Ballensiefen, Wiebke, Löbker, Yoana, Nuevo, Anna M G, Pasmooij, Peter G M, Mol
Publikováno v:
Clinical Pharmacology and Therapeutics, 113(2), 349-359. Nature Publishing Group
Important discoveries by academic drug developers hold the promise of bringing innovative treatments that address unmet medical needs to the market. However, the drug development process has proved to be challenging and demanding for academic researc
Autor:
Marko J. Kallio, Antti Poso, Lila Kallio, Arne Lindqvist, Pasi Halonen, Elvira Hukasova, Pekka Tiikkainen, Elli Narvi, Jonathan Rehnberg, Leena J. Laine, Jenni H.E. Mäki-Jouppila
Supplemental Movie 1. Cent-1 treated HeLa H2B-GFP mCherry-tubulin cells arrest in mitosis for several hours with misaligned chromosomes, followed by cell death or abnormal exit from M phase. The cell on the left hand side forms a multipolar spindle a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::048e2331a542dfa6a6340a8df14f34ef
https://doi.org/10.1158/1535-7163.22500160
https://doi.org/10.1158/1535-7163.22500160
Autor:
Marko J. Kallio, Antti Poso, Lila Kallio, Arne Lindqvist, Pasi Halonen, Elvira Hukasova, Pekka Tiikkainen, Elli Narvi, Jonathan Rehnberg, Leena J. Laine, Jenni H.E. Mäki-Jouppila
Mitosis is an attractive target for the development of new anticancer drugs. In a search for novel mitotic inhibitors, we virtually screened for low molecular weight compounds that would possess similar steric and electrostatic features, but differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e66c27df748880b1259d18eaba3507
https://doi.org/10.1158/1535-7163.c.6536371.v1
https://doi.org/10.1158/1535-7163.c.6536371.v1
Autor:
Leena J. Laine, Jenni H.E. Mäki-Jouppila, Emma Kutvonen, Pekka Tiikkainen, Thomas K.M. Nyholm, Jerry F. Tien, Neil T. Umbreit, Ville Härmä, Lila Kallio, Trisha N. Davis, Charles L. Asbury, Antti Poso, Gary J. Gorbsky, Marko J. Kallio
Publikováno v:
Oncoscience
Hec1 (Highly expressed in cancer 1) resides in the outer kinetochore where it works to facilitate proper kinetochore-microtubule interactions during mitosis. Hec1 is overexpressed in various cancers and its expression shows correlation with high tumo
Autor:
Viktoriia Starokozhko, Anne Heß, Wiebke Löbker, Wolfgang Ballensiefen, Eleonora Agricola, Bettina Ziegele, Marko J. Kallio, Laurence O’Dwyer, Yoana Nuevo, Peter G. M. Mol, Anna M. G. Pasmooij
Publikováno v:
Nature Reviews Drug Discovery. 22:251-252
Autor:
Marita Högberg, Linda Rickardson, Marko J. Kallio, Emma Kutvonen, Stefan Rehnmark, Satu Orasniemi
Publikováno v:
Drug Design, Development and Therapy
Linda Rickardson,1 Emma Kutvonen,2 Satu Orasniemi,2 Marita Högberg,1 Marko J Kallio,2,3 Stefan Rehnmark1 1Noviga Research AB, Södertälje, Sweden; 2Department of Physiology, Institute of Biomedicine, University of Turku, 3Centre for Biotechnology,
Autor:
Marko J. Kallio, Sofia Pruikkonen
Publikováno v:
British Journal of Cancer
Background: Several microRNA (miRNA) molecules have emerged as important post-transcriptional regulators of tumour suppressor and oncogene expression. Ras association domain family member 1 (RASSF1) is a critical tumour suppressor that controls multi
Publikováno v:
FEBS Letters. 590:2757-2767
Dual specificity phosphatase-3 (Dusp3/Vhr) regulates cell cycle progression by counteracting the effects of mitogen-activated protein kinases (Mapk) Erk1/2 and Jnk. Despite the known upregulation of Dusp3 at M phase in mammalian cells, its mitotic fu
Autor:
Per Eystein Lønning, Jenni H. Mäki-Jouppila, Mahesh Balasaheb Tambe, Marko J. Kallio, Ping Chen, Anne Hege Straume, Sampsa Hautaniemi, Bente Vilming Elgaaen, Ben Davidson, Olli Carpén, Kaisa Huhtinen, Sofia Pruikkonen
Publikováno v:
Oncotarget
The molecular pathways that contribute to the proliferation and drug response of cancer cells are highly complex and currently insufficiently characterized. We have identified a previously unknown microRNA-based mechanism that provides cancer cells m