Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Marko A. Peltoniemi"'
Autor:
M. Valtonen, Marko A. Peltoniemi, Oki Söderholm, Ville-Veikko Hynninen, Tuukka Saarikoski, Minna Kallioinen, Tommi Kauko, Jenni Aittokallio
Publikováno v:
Journal of Perioperative Practice
Since 2013, rotational thromboelastometry has been available in our hospital to assess coagulopathy. The aim of the study was to retrospectively evaluate the effect of thromboelastometry testing in cardiac surgery patients. Altogether 177 patients fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e44ee95f4e8570808d609cf1b925194d
https://doi.org/10.1177/1750458920950662
https://doi.org/10.1177/1750458920950662
Autor:
Janne T. Backman, Anri Tienhaara, Mika Kurkela, Tero Vahlberg, Marko A. Peltoniemi, Klaus T. Olkkola, Teijo I. Saari, Alexey Schramko, Martina Havrdová, Jouko Jalonen
Publikováno v:
The Journal of Clinical Pharmacology. 61:522-530
The capability of viscoelastic measurement parameters to screen anticoagulation activity of edoxaban in relation to its plasma concentrations was evaluated in 15 healthy male volunteers. Blood samples were drawn before the oral administration of edox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c348b3af3760bf6bcab3023bda23aef
https://doi.org/10.1002/jcph.1758
https://doi.org/10.1002/jcph.1758
Autor:
Petteri Kauhanen, Eliisa Löyttyniemi, Hanna von Plato, Marko A. Peltoniemi, Vesa P. Kontinen, Katri Hamunen
Publikováno v:
Acta Anaesthesiologica Scandinavica. 63:1406-1412
BACKGROUND Post-operative pain after an above-knee amputation is often severe, and in the elderly patients the adverse effects of post-operative opioids are evident. We hypothesized that continuous perineural local anesthetic infusion (CPI) combined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b006bafe660a0b0ae2b8c275d98aafe
https://doi.org/10.1111/aas.13440
https://doi.org/10.1111/aas.13440
Autor:
Vesa P. Kontinen, Kreu Maisniemi, Klaus T. Olkkola, Jukka Mulo, Taru Virtanen, Marko A. Peltoniemi, Teijo I. Saari, Venla Soini, Urmas Savolainen, Antti Liukas, Elina C. V. Brinck, P. Tarkkila, Sanna Mäkelä, Juho Rantakokko, Ville-Veikko Hynninen
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0252626 (2021)
PLoS ONE, Vol 16, Iss 6, p e0252626 (2021)
Background Spinal fusion surgery causes severe pain. Strong opioids, commonly used as postoperative analgesics, may have unwanted side effects. S-ketamine may be an effective analgesic adjuvant in opioid patient-controlled analgesia (PCA). However, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01fab95267c6ced01e9fa32ab698f5a9
https://doi.org/10.1101/2021.01.22.21250352
https://doi.org/10.1101/2021.01.22.21250352
Publikováno v:
Clinical Pharmacokinetics. 55:1059-1077
Ketamine is a phencyclidine derivative, which functions primarily as an antagonist of the N-methyl-D-aspartate receptor. It has no affinity for gamma-aminobutyric acid receptors in the central nervous system. Ketamine shows a chiral structure consist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb237e9be691fd1e8551549b60ab607
https://doi.org/10.1007/s40262-016-0383-6
https://doi.org/10.1007/s40262-016-0383-6
Autor:
Klaus T. Olkkola, Muhammad W. Ashraf, Pertti J. Neuvonen, Teijo I. Saari, Marko A. Peltoniemi
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
Low-dose oral S-ketamine is increasingly used in chronic pain therapy, but extensive cytochrome P450 (CYP) mediated metabolism makes it prone to pharmacokinetic drug-drug interactions (DDIs). In our study, concentration-time data from five studies we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08bd0e0fe746fb0de3167eec7afb03e8
http://hdl.handle.net/10138/299660
http://hdl.handle.net/10138/299660
Autor:
Marko A. Peltoniemi, Nora Hagelberg, Kaisa J. Kurkinen, Teijo I. Saari, Klaus T. Olkkola, Kari Laine, Pertti J. Neuvonen
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 111:325-332
Low-dose ketamine is currently used in several acute and chronic pain conditions as an analgesic. Ketamine undergoes extensive metabolism and is thus susceptible to drug-drug interactions. We examined the effect rifampicin, a well-known inducer of ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc580cec4b25953f02fce996deeb933e
https://doi.org/10.1111/j.1742-7843.2012.00908.x
https://doi.org/10.1111/j.1742-7843.2012.00908.x
Autor:
Marko A. Peltoniemi, Klaus T. Olkkola, Kari Laine, Nora Hagelberg, Teijo I. Saari, Pertti J. Neuvonen
Publikováno v:
European Journal of Clinical Pharmacology. 68:979-986
We examined the effect of grapefruit juice on the pharmacokinetics and pharmacodynamics of oral S-ketamine. A randomized crossover open-label study design with two phases at an interval of 4 weeks was conducted in 12 healthy volunteers. Grapefruit ju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b7e9f368419570c410d20e0f54c503d
https://doi.org/10.1007/s00228-012-1214-9
https://doi.org/10.1007/s00228-012-1214-9
Autor:
Miia Turpeinen, Marko A. Peltoniemi, Pertti J. Neuvonen, Petri Reponen, Nora Hagelberg, Klaus T. Olkkola, Teijo I. Saari, Kari Laine
Publikováno v:
Clinical Pharmacology & Therapeutics. 90:296-302
This study examined drug–drug interactions of oral S-ketamine with the cytochrome P450 (CYP) 2B6 inhibitor ticlopidine and the CYP3A inhibitor itraconazole. In this randomized, blinded, crossover study, 11 healthy volunteers ingested 0.2 mg/kg S-ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b16f47ff108b7018362328309344f7
https://doi.org/10.1038/clpt.2011.140
https://doi.org/10.1038/clpt.2011.140
Autor:
Nora Hagelberg, Teijo I. Saari, Pertti J. Neuvonen, Marko A. Peltoniemi, Klaus T. Olkkola, Kari Laine
Publikováno v:
Fundamental & Clinical Pharmacology. 26:743-750
Ketamine is an intravenous anaesthetic and analgesic agent but it can also be used orally as an adjuvant in the treatment of chronic pain. This study investigated the effect of the herbal antidepressant St John's wort, an inducer of cytochrome P450 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df0b96bc118689f7c8b4de5d906f2a93
https://doi.org/10.1111/j.1472-8206.2011.00954.x
https://doi.org/10.1111/j.1472-8206.2011.00954.x