Zobrazeno 1 - 10
of 194
pro vyhledávání: '"Marko, Anderluh"'
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Glycosylation of recombinant proteins is a post-translational modification that affects multiple physicochemical and biological properties of proteins. As such, it is a critical quality attribute that must be carefully controlled during protein produ
Externí odkaz:
https://doaj.org/article/1fa31120c52f466697120d062fd56fd5
Autor:
Maša Zorman, Maja Kokot, Irena Zdovc, Lidija Senerovic, Mina Mandic, Nace Zidar, Andrej Emanuel Cotman, Martina Durcik, Lucija Peterlin Mašič, Nikola Minovski, Marko Anderluh, Martina Hrast Rambaher
Publikováno v:
Antibiotics, Vol 13, Iss 11, p 1081 (2024)
Background: The novel bacterial topoisomerase inhibitors (NBTIs) developed in our laboratory show potent on-target enzyme inhibition but suffer from low activity against Gram-negative bacteria. Methods: With the aim of improving the antibacterial act
Externí odkaz:
https://doaj.org/article/18648e60153942908aeb787e7baf01d1
Autor:
Janja Sluga, Tihomir Tomašič, Marko Anderluh, Martina Hrast Rambaher, Gregor Bajc, Alen Sevšek, Nathaniel I. Martin, Roland J. Pieters, Marjana Novič, Katja Venko
Publikováno v:
Antibiotics, Vol 13, Iss 8, p 751 (2024)
Bacteria are capable of remarkable adaptations to their environment, including undesirable bacterial resistance to antibacterial agents. One of the most serious cases is an infection caused by multidrug-resistant Staphylococcus aureus, which has unfo
Externí odkaz:
https://doaj.org/article/a64f174040894b3aa54b7e163275ddbd
Publikováno v:
Antibiotics, Vol 12, Iss 5, p 930 (2023)
Novel bacterial topoisomerase inhibitors (NBTIs) are a new class of antibacterial agents that target bacterial type II topoisomerases (DNA gyrase and topoisomerase IV). Our recently disclosed crystal structure of an NBTI ligand in complex with DNA gy
Externí odkaz:
https://doaj.org/article/68891a99c78e450ea9dff5bb9cdc31c7
Autor:
Anja Kolarič, Thomas Germe, Martina Hrast, Clare E. M. Stevenson, David M. Lawson, Nicolas P. Burton, Judit Vörös, Anthony Maxwell, Nikola Minovski, Marko Anderluh
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The mechanism of DNA gyrase inhibitor stabilization of single-strand DNA cleavage breaks by DNA gyrase has been hypothetical. Here, the authors show experimental evidence of the mechanism using a library of inhibitors with improved binding and employ
Externí odkaz:
https://doaj.org/article/3c2f423c4f2146d28e6a3bf66952a1ce
Autor:
Matjaž Weiss, Elena M. Loi, Maša Sterle, Cyril Balsollier, Tihomir Tomašič, Roland J. Pieters, Martina Gobec, Marko Anderluh
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
O-GlcNAcylation is an important post-translational and metabolic process in cells that must be carefully regulated. O-GlcNAc transferase (OGT) is ubiquitously present in cells and is the only enzyme that catalyzes the transfer of O-GlcNAc to proteins
Externí odkaz:
https://doaj.org/article/bed20003ff6f4e85991d320f8a84b5ec
Autor:
Andrija Smelcerovic, Gordana Kocic, Mihajlo Gajic, Katarina Tomovic, Vukica Djordjevic, Dobrila Stankovic-Djordjevic, Marko Anderluh
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Since the outbreak of SARS-CoV-2 virus more than 12,500,000 cases have been reported worldwide. Patients suffering from diabetes and other comorbidities are particularly susceptible to severe forms of the COVID-19, which might result in chronic compl
Externí odkaz:
https://doaj.org/article/6b743e22ae3641d7bddde95fef56fff3
Autor:
Elena M. Loi, Tihomir Tomašič, Cyril Balsollier, Kevin van Eekelen, Matjaž Weiss, Martina Gobec, Matthew G. Alteen, David J. Vocadlo, Roland J. Pieters, Marko Anderluh
Publikováno v:
Molecules, Vol 27, Iss 6, p 1996 (2022)
O-GlcNAcylation is an essential post-translational modification installed by the enzyme O-β-N-acetyl-d-glucosaminyl transferase (OGT). Modulating this enzyme would be extremely valuable to better understand its role in the development of serious hum
Externí odkaz:
https://doaj.org/article/1b1043771f784525879d5b2d7670a274
Publikováno v:
Cells, Vol 10, Iss 12, p 3312 (2021)
The O-GlcNAcylation is a posttranslational modification of proteins regulated by O-GlcNAc transferase (OGT) and O-GlcNAcase. These enzymes regulate the development, proliferation and function of cells, including the immune cells. Herein, we focused o
Externí odkaz:
https://doaj.org/article/0e5f3da796b948ec9dd1a3c07211b04a
Autor:
Anja Kolarič, Maja Kokot, Martina Hrast, Matjaž Weiss, Irena Zdovc, Jurij Trontelj, Simon Žakelj, Marko Anderluh, Nikola Minovski
Publikováno v:
Antibiotics, Vol 10, Iss 7, p 862 (2021)
Herein, we report the design of a focused library of novel bacterial topoisomerase inhibitors (NBTIs) based on innovative mainly monocyclic right-hand side fragments active against DNA gyrase and Topo IV. They exhibit a very potent and wide range of
Externí odkaz:
https://doaj.org/article/3a9be81a740c4e36be2d85de170b35dd