O-Sulfated Bacterial Polysaccharides with Low Anticoagulant Activity Inhibit Metastasis

Autor: Markku Salmivirta, Anni Wärri, Anne Marjamäki, Rami Käkönen, Israel Vlodavsky, Sanna Maria Käkönen, Timo Veromaa, Benito Casu, Marjo Pihlavisto, Katri Hiilesvuo, Annamaria Naggi, Klaus Elenius, Marjut Borgenström, Giangiacomo Torri, Liisa Nissinen

Publikováno v: Seminars in Thrombosis and Hemostasis. 33:547-556

Heparin-like polysaccharides possess the capacity to inhibit cancer cell proliferation, angiogenesis, heparanase-mediated cancer cell invasion, and cancer cell adhesion to vascular endothelia via adhesion receptors, such as selectins. The clinical ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1527f01e521b1d5b891bab8435ddd5de
https://doi.org/10.1055/s-2007-982087

Novel Heparan Sulfate Structures Revealed by Monoclonal Antibodies

Autor: Keiichi Yoshida, Tiina Henttinen, Jacob van den Born, Katriina Salmivirta, Shuichi Miyaura, Nina Östman, Takeshi Ishimaru, Markku Salmivirta

Publikováno v: van den Born, J, Salmivirta, K, Henttinen, T, Ostman, N, Ishimaru, T, Miyaura, S, Yoshida, K & Salmivirta, M 2005, ' Novel heparan sulfate structures revealed by monoclonal antibodies ', Journal of Biological Chemistry, vol. 280, no. 21, pp. 20516-20523 . https://doi.org/10.1074/jbc.M502065200
The Journal of Biological Chemistry, 280(21), 20516-20523. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Journal of Biological Chemistry, 280(21), 20516-20523. American Society for Biochemistry and Molecular Biology Inc.

The sulfated glycosaminoglycan heparan sulfate (HS) is found ubiquitously on cell surfaces, in the extracellular matrix, and intracellularly as HS proteoglycans. Because of the structural heterogeneity of HS, tissue-derived HS preparations represent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::586f13f4aec1deb03d4b18b90a87b898
https://doi.org/10.1074/jbc.m502065200

Changes in Matrix Proteoglycans Induced by Insulin and Fatty Acids in Hepatic Cells May Contribute to Dyslipidemia of Insulin Resistance

Autor: Göran Bondjers, Gunnel Östergren Lundén, Mariam Rodríguez Lee, Germán Camejo, Urban Olsson, Malin Lorentzon, Markku Salmivirta, Ann-Charlotte Egnell

Publikováno v: Diabetes. 50:2126-2132

Insulin resistance and type 2 diabetes are associated with elevated circulating levels of insulin, nonesterified fatty acids (NEFAs), and lipoprotein remnants. Extracellular matrix proteoglycan (PG) alterations are also common in macro- and microvasc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::901a54111e2be33d9f31482a9537e1d0
https://doi.org/10.2337/diabetes.50.9.2126

Binding of Heparin/Heparan Sulfate to Fibroblast Growth Factor Receptor 4

Autor: Johan Kreuger, Markku Jalkanen, Britt-Marie Loo, Markku Salmivirta, Ulf Lindahl

Publikováno v: Journal of Biological Chemistry. 276:16868-16876

Fibroblast growth factors (FGFs) are heparin-binding polypeptides that affect the growth, differentiation, and migration of many cell types. FGFs signal by binding and activating cell surface FGF receptors (FGFRs) with intracellular tyrosine kinase d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c233978b0226973a1235184d00295be
https://doi.org/10.1074/jbc.m011226200

Structural Diversity of N-Sulfated Heparan Sulfate Domains: Distinct Modes of Glucuronyl C5 Epimerization, Iduronic Acid 2-O-Sulfation, and Glucosamine 6-O-Sulfation

Autor: Ulf Lindahl, Fariba Safaiyan, Markku Salmivirta

Publikováno v: Biochemistry. 39:10823-10830

The N-sulfated regions (NS domains) represent the modified sequences of heparan sulfate chains and mediate interactions of the polysaccharide with proteins. We have investigated the relationship between the type/extent of polymer modification and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1a2e1f366eb30bb910566b0ab3c2573
https://doi.org/10.1021/bi000411s