Zobrazeno 1 - 10
of 230
pro vyhledávání: '"Markku Heikinheimo"'
Autor:
Ruth Nousiainen, Katja Eloranta, Noora Isoaho, Stefano Cairo, David B. Wilson, Markku Heikinheimo, Marjut Pihlajoki
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Hepatoblastoma (HB) is the most common malignant liver tumor among children. To gain insight into the pathobiology of HB, we performed RNA sequence analysis on 5 patient-derived xenograft lines (HB-243, HB-279, HB-282, HB-284, HB-295) and 1 immortali
Externí odkaz:
https://doaj.org/article/6f58c76c3feb4663b3a8167829e08cce
Autor:
Nimish Godbole, Iiris Nyholm, Maria Hukkinen, Joseph R. Davidson, Athanasios Tyraskis, Jouko Lohi, Päivi Heikkilä, Katja Eloranta, Marjut Pihlajoki, Mark Davenport, Markku Heikinheimo, Antti Kyrönlahti, Mikko P. Pakarinen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Biliary atresia (BA) is a chronic neonatal cholangiopathy characterized by fibroinflammatory bile duct damage. Reliable biomarkers for predicting native liver survival (NLS) following portoenterostomy (PE) surgery are lacking. Herein we expl
Externí odkaz:
https://doaj.org/article/b4d732c72ecb46b58bab43a1c3cef9da
Autor:
Noora Andersson, Ulla-Maija Haltia, Anniina Färkkilä, Swee Chong Wong, Katja Eloranta, David B. Wilson, Leila Unkila-Kallio, Marjut Pihlajoki, Antti Kyrönlahti, Markku Heikinheimo
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 2, Pp 686-698 (2022)
Adult-type granulosa cell tumor (AGCT) is a rare ovarian malignancy characterized by slow growth and hormonal activity. The prognosis of AGCT is generally favorable, but one-third of patients with low-stage disease experience a late relapse, and over
Externí odkaz:
https://doaj.org/article/67436392599046bc89a87026e1cfbf9d
Autor:
Katja Eloranta, Marjut Pihlajoki, Emmi Liljeström, Ruth Nousiainen, Tea Soini, Jouko Lohi, Stefano Cairo, David B. Wilson, Seppo Parkkila, Markku Heikinheimo
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundIn response to hypoxia, tumor cells undergo transcriptional reprogramming including upregulation of carbonic anhydrase (CA) IX, a metalloenzyme that maintains acid-base balance. CAIX overexpression has been shown to correlate with poor prog
Externí odkaz:
https://doaj.org/article/27559198441c48d5a3bbac36626af92e
Autor:
Arie Passov, Minna Ilmakunnas, Marjut Pihlajoki, Kethe Hermunen, Marko Lempinen, Ilkka Helanterä, Villemikko Kailari, Markku Heikinheimo, Sture Andersson, Eero Pesonen
Publikováno v:
Intensive Care Medicine Experimental, Vol 9, Iss 1, Pp 1-15 (2021)
Abstract Background Acute Kidney Injury (AKI) is a common clinical complication. Plasma/serum neutrophil gelatinase-associated lipocalin (NGAL) has been proposed as a rapid marker of AKI. However, NGAL is not kidney-specific. It exists in three isofo
Externí odkaz:
https://doaj.org/article/e5e5f653dbca4be2b56bbea2ac24517c
Autor:
Antti Kyrönlahti, Nimish Godbole, Oyediran Akinrinade, Tea Soini, Iiris Nyholm, Noora Andersson, Maria Hukkinen, Jouko Lohi, David B. Wilson, Marjut Pihlajoki, Mikko P. Pakarinen, Markku Heikinheimo
Publikováno v:
Hepatology Communications, Vol 5, Iss 6, Pp 1036-1050 (2021)
Successful portoenterostomy (SPE) improves the short‐term outcome of patients with biliary atresia (BA) by relieving cholestasis and extending survival with native liver. Despite SPE, hepatic fibrosis progresses in most patients, leading to cirrhos
Externí odkaz:
https://doaj.org/article/d6a19489d60a46e8b0ae08a646fdd50e
Autor:
Maria Hurskainen, Ivana Mižíková, David P. Cook, Noora Andersson, Chanèle Cyr-Depauw, Flore Lesage, Emmi Helle, Laurent Renesme, Robert P. Jankov, Markku Heikinheimo, Barbara C. Vanderhyden, Bernard Thébaud
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
It is unclear how changes in gene expression are induced by changes in oxygen levels during late lung development. Here, the authors provide data from MULTI-seq scRNAseq in mice showing exposure to higher oxygen levels affects cell fates, especially
Externí odkaz:
https://doaj.org/article/f32cc8aebe874074a51d470766b32ce0
Autor:
Linnea Äärelä, Pauliina Hiltunen, Tea Soini, Nina Vuorela, Heini Huhtala, Pasi I. Nevalainen, Markku Heikinheimo, Laura Kivelä, Kalle Kurppa
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-11 (2020)
Abstract Background Introduction of nitisinone and newborn screening (NBS) have transformed the treatment of type 1 tyrosinemia, but the effects of these changes on the long-term outcomes remain obscure. Also, the predictors for later complications,
Externí odkaz:
https://doaj.org/article/a72bc7f492cb4404858e8b385f88a51f
Autor:
Katja Eloranta, Ruth Nousiainen, Stefano Cairo, Mikko P. Pakarinen, David B. Wilson, Marjut Pihlajoki, Markku Heikinheimo
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2021)
The neuropilins NRP1 and NRP2 are multifunctional glycoproteins that have been implicated in several cancer-related processes including cell survival, migration, and invasion in various tumor types. Here, we examine the role of neuropilins in hepatob
Externí odkaz:
https://doaj.org/article/e8fe8125923d478bad37165f2ea2bdba
Autor:
Katja Eloranta, Stefano Cairo, Emmi Liljeström, Tea Soini, Antti Kyrönlahti, Jean-Gabriel Judde, David B. Wilson, Markku Heikinheimo, Marjut Pihlajoki
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Background: Hepatoblastoma (HB) is the most common pediatric liver malignancy. Despite advances in chemotherapeutic regimens and surgical techniques, the survival of patients with advanced HB remains poor, underscoring the need for new therapeutic ap
Externí odkaz:
https://doaj.org/article/9cf94d15b3844ceca7251741247b569d