Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Markku Hakala"'
Autor:
Markku Hakala
Publikováno v:
University of Helsinki
Polymerization of actin filaments against cellular membranes and contraction of actomyosin fibers generate pushing and pulling forces for cell migration, endocytosis, cell division, and maintenance of cell morphology, as well as for intracellular mot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8ed23d2616801e92f5481a3fbe14071d
http://hdl.handle.net/10138/312660
http://hdl.handle.net/10138/312660
Autor:
Hugo Wioland, Guillaume Romet-Lemonne, Antoine Jégou, Pekka Lappalainen, Markku Hakala, Mari Tolonen
Coordinated polymerization of actin filaments provides force for cell migration, morphogenesis, and endocytosis. Capping Protein (CP) is central regulator of actin dynamics in all eukaryotes. It binds actin filament (F-actin) barbed ends with high af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30be22951737cfa812a8f5685d1ef0b3
Autor:
Markku Hakala, Hugo Wioland, Guillaume Romet-Lemonne, Pekka Lappalainen, Antoine Jégou, Tommi Kotila, Mari Tolonen
Publikováno v:
Nature Cell Biology. 23:437-438
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f583f066f15f30c9497d25c19efc067
https://doi.org/10.1038/s41556-021-00651-8
https://doi.org/10.1038/s41556-021-00651-8
Autor:
Mari Tolonen, Guillaume Romet-Lemonne, Antoine Jégou, Hugo Wioland, Pekka Lappalainen, Tommi Kotila, Markku Hakala
Publikováno v:
Nature Cell Biology
Nature Cell Biology, Nature Publishing Group, 2021, 23 (2), pp.147-159. ⟨10.1038/s41556-020-00629-y⟩
Nature Cell Biology, Nature Publishing Group, 2021, 23 (2), pp.147-159. ⟨10.1038/s41556-020-00629-y⟩
Coordinated polymerization of actin filaments provides force for cell migration, morphogenesis and endocytosis. Capping protein (CP) is a central regulator of actin dynamics in all eukaryotes. It binds to actin filament (F-actin) barbed ends with hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b821c390c0ec2095d6de0c8607e3572
https://pubmed.ncbi.nlm.nih.gov/33654262
https://pubmed.ncbi.nlm.nih.gov/33654262
Publikováno v:
Hakala, M, Kalimeri, M, Enkavi, G, Vattulainen, I & Lappalainen, P 2018, ' Molecular mechanism for inhibition of twinfilin by phosphoinositides ', Journal of Biological Chemistry, vol. 293, no. 13, pp. 4818-4829 . https://doi.org/10.1074/jbc.RA117.000484
Membrane phosphoinositides control organization and dynamics of the actin cytoskeleton by regulating the activities of several key actin-binding proteins. Twinfilin is an evolutionarily conserved protein that contributes to cytoskeletal dynamics by i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab31f9f1165ef92e29cfff5dc7c29e8c
http://hdl.handle.net/10138/307511
http://hdl.handle.net/10138/307511
Publikováno v:
Scandinavian Journal of Rheumatology. 44:173-181
Better treatment strategies and therapeutic options have changed the treatment of rheumatoid arthritis (RA) during the past decade. Our objective was to examine clinical and patient-reported outcomes in patients with RA treated in 1998-99 and 2011-12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbe42812ba7e9dc2c56ae34292dbb644
https://doi.org/10.3109/03009742.2014.957240
https://doi.org/10.3109/03009742.2014.957240
Autor:
Pekka Lappalainen, Xiaoping Du, Sarah Beck, Bernhard Nieswandt, Timo Vögtle, Simon Stritt, Markku Hakala, Attila Braun, Katrin G. Heinze, Markus Bender, Isabelle C. Becker
Publikováno v:
Blood. 130(15)
Regulated reorganization of the actin cytoskeleton is a prerequisite for proper platelet production and function. Consequently, defects in proteins controlling actin dynamics have been associated with platelet disorders in humans and mice. Twinfilin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e2f890dcc76a270d39f8f5726db6222
https://pubmed.ncbi.nlm.nih.gov/29025716
https://pubmed.ncbi.nlm.nih.gov/29025716
Publikováno v:
Scandinavian Journal of Rheumatology. 43:279-285
To assess the impact of abdominal obesity (AO) on disease severity, cardiovascular risk factors, and patient-reported outcomes (PROs) in patients with rheumatoid arthritis (RA).Two hundred and thirty consecutive outpatients were cross-sectionally ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02eddd20d28c1e7f5782323386467608
https://doi.org/10.3109/03009742.2013.858769
https://doi.org/10.3109/03009742.2013.858769
Publikováno v:
Annals of the Rheumatic Diseases. 73:1793-1796
Objective We describe the epidemiological and microbiological process in the clearing of a foodborne outbreak of Yersinia pseudotuberculosis O:1 linked to raw carrots and frequency of the associated reactive extra-gastrointestinal manifestations. Met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8b3227152b7c6b7374d1a838dd05039
https://doi.org/10.1136/annrheumdis-2013-203431
https://doi.org/10.1136/annrheumdis-2013-203431
Publikováno v:
Handbook of experimental pharmacology. 235
Cell migration is necessary for several developmental processes in multicellular organisms. Furthermore, many physiological processes such as wound healing and immunological events in adult animals are dependent on cell migration. Consequently, defec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b666fda89f1207a5a864ff591e86755c
https://pubmed.ncbi.nlm.nih.gov/27469496
https://pubmed.ncbi.nlm.nih.gov/27469496