Zobrazeno 1 - 10
of 245
pro vyhledávání: '"Markku, Varjosalo"'
Autor:
Susanna Nousiainen, Outi Kuismin, Siiri Reinikka, Roosa Manninen, Sara Khamaiseh, Mari Kuivalainen, Anna Terho, Sari Koivurova, Maarit Niinimäki, Kari Salokas, Markku Varjosalo, Anne Ahtikoski, Ralf Bützow, Outi Lindgren, Outi Uimari, Pia Vahteristo
Publikováno v:
Human Genomics, Vol 17, Iss 1, Pp 1-10 (2023)
Abstract Background Endometriosis is a common, chronic disease among fertile-aged women. Disease course may be highly invasive, requiring extensive surgery. The etiology of endometriosis remains elusive, though a high level of heritability is well es
Externí odkaz:
https://doaj.org/article/6dacf57f4e0f49a8840d6d3a6215fa94
Autor:
Ashik Jawahar Deen, Simone Adinolfi, Jouni Härkönen, Tommi Patinen, Xiaonan Liu, Tuomo Laitinen, Piia Takabe, Kirsi Kainulainen, Sanna Pasonen-Seppänen, Lisa M. Gawriyski, Uma Thanigai Arasu, Ilakya Selvarajan, Petri Mäkinen, Hanna Laitinen, Emilia Kansanen, Minna U. Kaikkonen, Antti Poso, Markku Varjosalo, Anna-Liisa Levonen
Publikováno v:
Redox Biology, Vol 69, Iss , Pp 103031- (2024)
The Kelch-like ECH-associated protein 1 (KEAP1) – Nuclear factor erythroid 2 -related factor 2 (NRF2) pathway is the major transcriptional stress response system in cells against oxidative and electrophilic stress. NRF2 is frequently constitutively
Externí odkaz:
https://doaj.org/article/6424cb4692934e1e8076ab053da688af
Autor:
Emilia Piki, Alice Dini, Juuli Raivola, Kari Salokas, Kaiyang Zhang, Markku Varjosalo, Teijo Pellinen, Katja Välimäki, Kristina Tabor Veskimäe, Synnöve Staff, Sampsa Hautaniemi, Astrid Murumägi, Daniela Ungureanu
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-10 (2023)
Abstract Wnt pathway dysregulation through genetic and non-genetic alterations occurs in multiple cancers, including ovarian cancer (OC). The aberrant expression of the non-canonical Wnt signaling receptor ROR1 is thought to contribute to OC progress
Externí odkaz:
https://doaj.org/article/a88f0a5d9ef74d3ba66b390c6a8db639
Autor:
Katri Vaparanta, Anne Jokilammi, Mahlet Tamirat, Johannes A. M. Merilahti, Kari Salokas, Markku Varjosalo, Johanna Ivaska, Mark S. Johnson, Klaus Elenius
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Specificity in signaling activated by receptor tyrosine kinases is typically attributed to characteristics of their intracellular domains. Here, the authors demonstrate that an extracellular receptor sequence motif controls intracellular signaling as
Externí odkaz:
https://doaj.org/article/a1f72bfdc3b24f3ba724cff785319be7
Autor:
Juuli Raivola, Alice Dini, Hanna Karvonen, Emilia Piki, Kari Salokas, Wilhelmiina Niininen, Laura Kaleva, Kaiyang Zhang, Mariliina Arjama, Greta Gudoityte, Brinton Seashore-Ludlow, Markku Varjosalo, Olli Kallioniemi, Sampsa Hautaniemi, Astrid Murumägi, Daniela Ungureanu
Publikováno v:
Cell Death and Disease, Vol 13, Iss 8, Pp 1-12 (2022)
Abstract Most patients with ovarian cancer (OC) are diagnosed at a late stage when there are very few therapeutic options and a poor prognosis. This is due to the lack of clearly defined underlying mechanisms or an oncogenic addiction that can be tar
Externí odkaz:
https://doaj.org/article/47baa86ead214039b8cd980a88935c5f
Autor:
Lisa Gawriyski, Eeva-Mari Jouhilahti, Masahito Yoshihara, Liangru Fei, Jere Weltner, Tomi T. Airenne, Ras Trokovic, Shruti Bhagat, Mari H. Tervaniemi, Yasuhiro Murakawa, Kari Salokas, Xiaonan Liu, Sini Miettinen, Thomas R. Bürglin, Biswajyoti Sahu, Timo Otonkoski, Mark S. Johnson, Shintaro Katayama, Markku Varjosalo, Juha Kere
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106172- (2023)
Summary: The paired-like homeobox transcription factor LEUTX is expressed in human preimplantation embryos between the 4- and 8-cell stages, and then silenced in somatic tissues. To characterize the function of LEUTX, we performed a multiomic charact
Externí odkaz:
https://doaj.org/article/1b78c910dbd44d44b717a1317ad6a139
Autor:
Salla M. Kangas, Jaakko Teppo, Maija J. Lahtinen, Anu Suoranta, Bishwa Ghimire, Pirkko Mattila, Johanna Uusimaa, Markku Varjosalo, Jani Katisko, Reetta Hinttala
Publikováno v:
Translational Neurodegeneration, Vol 11, Iss 1, Pp 1-16 (2022)
Abstract Background Transcriptomic and proteomic profiling of human brain tissue is hindered by the availability of fresh samples from living patients. Postmortem samples usually represent the advanced disease stage of the patient. Furthermore, the p
Externí odkaz:
https://doaj.org/article/01bcf4d50e8f47fa87519123d6cba3ff
Autor:
Farhana Jahan, Jan Koski, Diana Schenkwein, Seppo Ylä-Herttuala, Helka Göös, Sini Huuskonen, Markku Varjosalo, Pilvi Maliniemi, Judith Leitner, Peter Steinberger, Hans-Jörg Bühring, Kim Vettenranta, Matti Korhonen
Publikováno v:
Frontiers in Molecular Medicine, Vol 3 (2023)
Background: T cells that are genetically modified with chimeric antigen receptor (CAR) hold promise for immunotherapy of cancer. Currently, there are intense efforts to improve the safety and efficacy of CAR T cell therapies against liquid and solid
Externí odkaz:
https://doaj.org/article/99b6cf95a3c24eb697aeaeaaf665b268
Autor:
Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Transcription factors (TFs) interact with several other proteins in the process of transcriptional regulation. Here the authors identify 6703 and 1536 protein–protein interactions for 109 different human TFs through BioID and AP-MS analyses, respec
Externí odkaz:
https://doaj.org/article/67c33cf493234878a8d14411ff4708ab
Autor:
Matias Kinnunen, Xiaonan Liu, Elina Niemelä, Tiina Öhman, Lisa Gawriyski, Kari Salokas, Salla Keskitalo, Markku Varjosalo
Publikováno v:
Cancers, Vol 15, Iss 17, p 4246 (2023)
Chromosomal translocations creating fusion genes are common cancer drivers. The oncogenic ETV6-NTRK3 (EN) gene fusion joins the sterile alpha domain of the ETV6 transcription factor with the tyrosine kinase domain of the neurotrophin-3 receptor NTRK3
Externí odkaz:
https://doaj.org/article/3402565ad7c54bffa399ae262236776e