Výsledky vyhledávání - "Markku, Saloheimo"

Akademický článek

Modification of transcriptional factor ACE3 enhances protein production in Trichoderma reesei in the absence of cellulase gene inducer

Autor: Yun Luo, Mari Valkonen, Raymond E. Jackson, Jonathan M. Palmer, Aditya Bhalla, Igor Nikolaev, Markku Saloheimo, Michael Ward

Publikováno v: Biotechnology for Biofuels, Vol 13, Iss 1, Pp 1-16 (2020)

Abstract Background Trichoderma reesei is one of the best-known cellulolytic organisms, producing large quantities of a complete set of extracellular cellulases and hemicellulases for the degradation of lignocellulosic substances. Hence, T. reesei is

Externí odkaz: https://doaj.org/article/21f8cc5bc3b84751b11e1ef4e4482c46

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Akademický článek

Thermophilic Filamentous Fungus C1-Cell-Cloned SARS-CoV-2-Spike-RBD-Subunit-Vaccine Adjuvanted with Aldydrogel®85 Protects K18-hACE2 Mice against Lethal Virus Challenge

Publikováno v: Vaccines, Vol 10, Iss 12, p 2119 (2022)

SARS-CoV-2 is evolving with increased transmission, host range, pathogenicity, and virulence. The original and mutant viruses escape host innate (Interferon) immunity and adaptive (Antibody) immunity, emphasizing unmet needs for high-yield, commercia

Externí odkaz: https://doaj.org/article/8087098534aa48d98dd5ffae26105a5c

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Akademický článek

The Highly Productive Thermothelomyces heterothallica C1 Expression System as a Host for Rapid Development of Influenza Vaccines

Autor: Gabor Keresztes, Mark Baer, Mark R. Alfenito, Theo C. Verwoerd, Andriy Kovalchuk, Marilyn G. Wiebe, Tor Kristian Andersen, Markku Saloheimo, Ronen Tchelet, Richard Kensinger, Gunnveig Grødeland, Mark Emalfarb

Publikováno v: Vaccines, Vol 10, Iss 2, p 148 (2022)

(1) Influenza viruses constantly change and evade prior immune responses, forcing seasonal re-vaccinations with updated vaccines. Current FDA-approved vaccine manufacturing technologies are too slow and/or expensive to quickly adapt to mid-season cha

Externí odkaz: https://doaj.org/article/c17043cd61fe4ba9908412126993a4c3

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Preclinical immunogenicity and protective efficacy of a SARS-CoV-2 RBD-based vaccine produced with the thermophilic filamentous fungal expression system Thermothelomyces heterothallica C1

Autor: Albert Osterhaus, Mariana Gonzalez-Hernandez, Franziska Kaiser, Imke Steffen, Malgorzata Ciurkiewicz, Geert van Amerongen, Ronen Tchelet, Mark Emalfarb, Markku Saloheimo, Marilyn Wiebe, Marika Vitikainen, Irina Albulescu, Berend-Jan Bosch, Wolfgang Baumgärtner, Bart Haagmans

INTRODUCTION: The emergency use of vaccines has been the most efficient way to control the coronavirus disease 19 (COVID-19) pandemic. However, the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern has redu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2a3589eb311ae1fa109c14642c0f9b
https://dspace.library.uu.nl/handle/1874/429322

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Akademický článek

Development of a Modular Vaccine Platform for Multimeric Antigen Display Using an Orthobunyavirus Model

Autor: Andrea Aebischer, Kerstin Wernike, Patricia König, Kati Franzke, Paul J. Wichgers Schreur, Jeroen Kortekaas, Marika Vitikainen, Marilyn Wiebe, Markku Saloheimo, Ronen Tchelet, Jean-Christophe Audonnet, Martin Beer

Publikováno v: Vaccines, Vol 9, Iss 6, p 651 (2021)

Emerging infectious diseases represent an increasing threat to human and animal health. Therefore, safe and effective vaccines that could be available within a short time frame after an outbreak are required for adequate prevention and control. Here,

Externí odkaz: https://doaj.org/article/ccefcfc07e394bb8a5a7e86086357dd8

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Toxicity and Local Tolerance of a Novel Spike Protein RBD Vaccine Against SARS-CoV-2, Produced Using the C1 Thermothelomyces Heterothallica Protein Expression Platform

Autor: Yuval Ramot, Noam Kronfeld, Yakir Ophir, Nati Ezov, Sheli Friedman, Markku Saloheimo, Marika Vitikainen, Hanna Ben-Artzi, Avi Avigdor, Ronen Tchelet, Noelia Valbuena Crespo, Mark Emalfarb, Abraham Nyska

Publikováno v: Ramot, Y, Kronfeld, N, Ophir, Y, Ezov, N, Friedman, S, Saloheimo, M, Vitikainen, M, Ben-Artzi, H, Avigdor, A, Tchelet, R, Valbuena Crespo, N, Emalfarb, M & Nyska, A 2022, ' Toxicity and Local Tolerance of a Novel Spike Protein RBD Vaccine Against SARS-CoV-2, Produced Using the C1 Thermothelomyces Heterothallica Protein Expression Platform ', Toxicologic Pathology, vol. 50, no. 3, pp. 294-307 . https://doi.org/10.1177/01926233221090518

Coronavirus disease 2019 (COVID-19) has caused the ongoing COVID-19 pandemic and there is a growing demand for safe and effective vaccines. The thermophilic Thermothelomyces heterothallica filamentous fungal host, C1-cell, can be utilized as an expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f79b567e7cfca14a7dc07a5fcc0676
https://cris.vtt.fi/en/publications/7d21d8d0-a135-4ea9-8a15-c38154829a22

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Akademický článek

A new crystal form of Aspergillus oryzae catechol oxidase and evaluation of copper site structures in coupled binuclear copper enzymes.

Autor: Leena Penttinen, Chiara Rutanen, Markku Saloheimo, Kristiina Kruus, Juha Rouvinen, Nina Hakulinen

Publikováno v: PLoS ONE, Vol 13, Iss 5, p e0196691 (2018)

Coupled binuclear copper (CBC) enzymes have a conserved type 3 copper site that binds molecular oxygen to oxidize various mono- and diphenolic compounds. In this study, we found a new crystal form of catechol oxidase from Aspergillus oryzae (AoCO4) a

Externí odkaz: https://doaj.org/article/57e69b0feb694d14bee39c8a4c6bc899

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