The metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thrombosis.

Autor: Nayak MK; Department of Internal Medicine, Division of Hematology/Oncology, and., Ghatge M; Department of Internal Medicine, Division of Hematology/Oncology, and., Flora GD; Department of Internal Medicine, Division of Hematology/Oncology, and., Dhanesha N; Department of Internal Medicine, Division of Hematology/Oncology, and., Jain M; Department of Internal Medicine, Division of Hematology/Oncology, and., Markan KR; Department of Neuroscience and Pharmacology, University of Iowa, Iowa City, IA; and., Potthoff MJ; Department of Neuroscience and Pharmacology, University of Iowa, Iowa City, IA; and.; Department of Veterans Affairs Medical Center, Iowa City, IA., Lentz SR; Department of Internal Medicine, Division of Hematology/Oncology, and., Chauhan AK; Department of Internal Medicine, Division of Hematology/Oncology, and.

Publikováno v: Blood [Blood] 2021 Mar 25; Vol. 137 (12), pp. 1658-1668.

Pdgfrα-Cre mediated knockout of the aryl hydrocarbon receptor protects mice from high-fat diet induced obesity and hepatic steatosis.

Autor: Gourronc FA; Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, United States of America., Markan KR; Department of Neuroscience and Pharmacology, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, IA, United States of America., Kulhankova K; Department of Pediatrics, University of Iowa, Iowa City, IA, United States of America., Zhu Z; Department of Internal Medicine, University of Iowa, Iowa City, IA, United States of America., Sheehy R; Department of Pharmacology, Kansas City University, Kansas City, KS, United States of America., Quelle DE; Department of Neuroscience and Pharmacology, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, IA, United States of America., Zingman LV; Department of Internal Medicine, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, IA, United States of America., Kurago ZB; Department of Oral Biology and Diagnostic Sciences, Department of Pathology, Augusta University, Augusta, GA, United States of America., Ankrum JA; Roy J. Carver Department of Biomedical Engineering, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, IA, United States of America., Klingelhutz AJ; Department of Microbiology and Immunology, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, IA, United States of America.

Publikováno v: PloS one [PLoS One] 2020 Jul 30; Vol. 15 (7), pp. e0236741. Date of Electronic Publication: 2020 Jul 30 (Print Publication: 2020).

Liver Derived FGF21 Maintains Core Body Temperature During Acute Cold Exposure.

Autor: Ameka M; Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA., Markan KR; Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA., Morgan DA; Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA., BonDurant LD; Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA., Idiga SO; Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA., Naber MC; Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA., Zhu Z; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.; Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.; Department of Veterans Affairs Medical Center, Iowa City, IA, 52242, USA., Zingman LV; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.; Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.; Department of Veterans Affairs Medical Center, Iowa City, IA, 52242, USA., Grobe JL; Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.; Obesity Research and Education Initiative, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA., Rahmouni K; Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA., Potthoff MJ; Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA. matthew-potthoff@uiowa.edu.; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA. matthew-potthoff@uiowa.edu.; Obesity Research and Education Initiative, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA. matthew-potthoff@uiowa.edu.

Publikováno v: Scientific reports [Sci Rep] 2019 Jan 24; Vol. 9 (1), pp. 630. Date of Electronic Publication: 2019 Jan 24.

Scaffold-free generation of uniform adipose spheroids for metabolism research and drug discovery.

Autor: Klingelhutz AJ; University of Iowa Fraternal Order of Eagles Diabetes Research Center, 169 Newton Rd, Iowa City, IA, 52242, USA. al-klingelhutz@uiowa.edu.; Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA. al-klingelhutz@uiowa.edu., Gourronc FA; Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA., Chaly A; Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA., Wadkins DA; University of Iowa Fraternal Order of Eagles Diabetes Research Center, 169 Newton Rd, Iowa City, IA, 52242, USA.; Department of Biomedical Engineering, University of Iowa, Iowa City, IA, 52242, USA., Burand AJ; University of Iowa Fraternal Order of Eagles Diabetes Research Center, 169 Newton Rd, Iowa City, IA, 52242, USA.; Department of Biomedical Engineering, University of Iowa, Iowa City, IA, 52242, USA., Markan KR; University of Iowa Fraternal Order of Eagles Diabetes Research Center, 169 Newton Rd, Iowa City, IA, 52242, USA.; Department of Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA., Idiga SO; University of Iowa Fraternal Order of Eagles Diabetes Research Center, 169 Newton Rd, Iowa City, IA, 52242, USA.; Department of Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA., Wu M; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA.; Division of Medicinal and Natural Products Chemistry, Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, 115 S. Grand Ave, Iowa City, IA, 52242, USA.; High Throughput Screening Core Facility at University of Iowa (UIHTS), University of Iowa, 115 S. Grand Ave, Iowa City, IA, 52242, USA., Potthoff MJ; University of Iowa Fraternal Order of Eagles Diabetes Research Center, 169 Newton Rd, Iowa City, IA, 52242, USA.; Department of Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA., Ankrum JA; University of Iowa Fraternal Order of Eagles Diabetes Research Center, 169 Newton Rd, Iowa City, IA, 52242, USA. james-ankrum@uiowa.edu.; Department of Biomedical Engineering, University of Iowa, Iowa City, IA, 52242, USA. james-ankrum@uiowa.edu.

Publikováno v: Scientific reports [Sci Rep] 2018 Jan 11; Vol. 8 (1), pp. 523. Date of Electronic Publication: 2018 Jan 11.

FGF21 resistance is not mediated by downregulation of beta-klotho expression in white adipose tissue.

Autor: Markan KR; Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA., Naber MC; Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA., Small SM; Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA., Peltekian L; Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA., Kessler RL; Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA., Potthoff MJ; Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.

Publikováno v: Molecular metabolism [Mol Metab] 2017 Mar 27; Vol. 6 (6), pp. 602-610. Date of Electronic Publication: 2017 Mar 27 (Print Publication: 2017).