Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Mark. J. Turner"'
Publikováno v:
Cellular Physiology and Biochemistry, Vol 55, Iss 6, Pp 784-804 (2021)
Externí odkaz:
https://doaj.org/article/d60a3471a4d748cfb297499323555b32
Autor:
John W. Hanrahan, Asmahan Abu-Arish, Francis H. Wong, Mark J. Turner, Graeme W. Carlile, David Y. Thomas, André M. Cantin
Publikováno v:
American Journal of Physiology-Cell Physiology. 323:C1374-C1392
Chronic obstructive pulmonary disease (COPD) is a leading cause of death and cigarette smoke is the main risk factor. Detecting its earliest stages and preventing a decline in lung function are key goals. The pathogenesis of COPD is complex but has s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e24c6b6fb56320993629928e6fa34a5
https://doi.org/10.1152/ajpcell.00356.2022
https://doi.org/10.1152/ajpcell.00356.2022
Autor:
Yukiko Sato, Dusik Kim, Mark J. Turner, Yishan Luo, Syeda Sadaf Zehra Zaidi, David Y Thomas, John W Hanrahan
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7de4528e273b4f40ae4e256e73f52714
https://doi.org/10.1165/rcmb.2022-0241oc
https://doi.org/10.1165/rcmb.2022-0241oc
Autor:
Asmahan Abu-Arish, Elvis Pandžić, Yishan Luo, Yukiko Sato, Mark J. Turner, Paul W. Wiseman, John W. Hanrahan
Publikováno v:
Biophysical Journal. 122:173a-174a
Membrane proteins often cluster in nanoscale membrane domains (lipid rafts) that coalesce into ceramide-rich platforms during cell stress, however the clustering mechanisms remain uncertain. The cystic fibrosis transmembrane conductance regulator (CF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51474aab637040eb0dc7e53eee0bf064
https://doi.org/10.1016/j.bpj.2022.11.1084
https://doi.org/10.1016/j.bpj.2022.11.1084
Publikováno v:
The British journal of oralmaxillofacial surgery. 60(9)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a0ca76fd5f6be954a4921dcdc660c6
https://pubmed.ncbi.nlm.nih.gov/35963807
https://pubmed.ncbi.nlm.nih.gov/35963807
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 375:414-429
Cystic fibrosis (CF) is caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) anion channel that impair airway salt and fluid secretion. Excessive release of pro-inflammatory cytokines and chemokines by CF bronchial ep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26401eef035ba193c3b0e3b94107aabf
https://doi.org/10.1124/jpet.120.000080
https://doi.org/10.1124/jpet.120.000080
Publikováno v:
The British journal of oralmaxillofacial surgery. 60(8)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f037a6f862f4d0c209b24ada5f6e8095
https://pubmed.ncbi.nlm.nih.gov/34663525
https://pubmed.ncbi.nlm.nih.gov/34663525
Autor:
John W. Hanrahan, David Y. Thomas, Graeme W. Carlile, Iris A.L. Silva, Margarida D. Amaral, Miquéias Lopes-Pacheco, Elvira Sondo, Mark J. Turner, Nicoletta Pedemonte
Publikováno v:
Biochemical pharmacology. 180
Despite progress in developing pharmacotherapies to rescue F508del-CFTR, the most prevalent Cystic Fibrosis (CF)-causing mutation, individuals homozygous for this mutation still face several disease-related symptoms. Thus, more potent compound combin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be00727680859e48da61f3475ccf22a
https://pubmed.ncbi.nlm.nih.gov/32628927
https://pubmed.ncbi.nlm.nih.gov/32628927
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 318(5)
Over 2,000 mutations have been reported in the cystic fibrosis transmembrane conductance regulator ( cftr) gene, many of which cause disease but are rare and have no effective treatment. Thus, there is an unmet need for new, mutation-agnostic therapi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a01b30513b62a12b36f5f4d99c78eb
https://pubmed.ncbi.nlm.nih.gov/32159371
https://pubmed.ncbi.nlm.nih.gov/32159371
Publikováno v:
Pharmacology & Therapeutics. 224:107826
Cystic Fibrosis (CF) lung disease results from mutations in the CFTR anion channel that reduce anion and fluid secretion by airway epithelia. Impaired secretion compromises airway innate defence mechanisms and leads to bacterial colonization, excessi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff284489eb0f8b17397ef4a27f5305d
https://doi.org/10.1016/j.pharmthera.2021.107826
https://doi.org/10.1016/j.pharmthera.2021.107826