Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mark-Phillip Pebworth"'
Autor:
Samir Rachid Zaim, Mark-Phillip Pebworth, Imran McGrath, Lauren Okada, Morgan Weiss, Julian Reading, Julie L. Czartoski, Troy R. Torgerson, M. Juliana McElrath, Thomas F. Bumol, Peter J. Skene, Xiao-jun Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Single-cell assay for transposase-accessible chromatin using sequencing (scATAC-seq) is being increasingly used to study gene regulation. However, major analytical gaps limit its utility in studying gene regulatory programs in complex diseas
Externí odkaz:
https://doaj.org/article/510a659dc6a34101b8936defcaa98168
Autor:
Xiaoyu Yang, Seth Bergenholtz, Lenka Maliskova, Mark-Phillip Pebworth, Arnold R Kriegstein, Yun Li, Yin Shen
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0228760 (2020)
Accurate RNA quantification at the single-cell level is critical for understanding the dynamics of gene expression and regulation across space and time. Single molecule FISH (smFISH), such as RNAscope, provides spatial and quantitative measurements o
Externí odkaz:
https://doaj.org/article/3ea612fd40ed46d1990dabc3c7e1908f
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110453 (2014)
Current studies investigating the role of biophysical cues on cell migration focus on the use of culture platforms with static material parameters. However, migrating cells in vivo often encounter spatial variations in extracellular matrix stiffness.
Externí odkaz:
https://doaj.org/article/185cd21e293243f081e7c488ce5b39a3
Autor:
Claire E. Gustafson, Zachary Thomson, Ziyuan He, Elliott Swanson, Katherine Henderson, Mark-Phillip Pebworth, Lauren Y. Okada, Alexander T. Heubeck, Charles R. Roll, Veronica Hernandez, Morgan Weiss, Palak C. Genge, Julian Reading, Josephine R. Giles, Sasikanth Manne, Jeanette Dougherty, CJ Jasen, Allison R. Greenplate, Lynne A. Becker, Lucas T. Graybuck, Suhas V. Vasaikar, Gregory L. Szeto, Adam K. Savage, Cate Speake, Jane H. Buckner, Xiao-jun Li, Troy R. Torgerson, E. John Wherry, Thomas F. Bumol, Laura A. Vella, Sarah E. Henrickson, Peter J. Skene
The naive T cell compartment undergoes multiple changes across age that associate with altered susceptibility to infection and autoimmunity. In addition to the acquisition of naive-like memory T cell subsets, mouse studies describe substantial molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::510ab66e66b266ad28cf5b58559c3b29
https://doi.org/10.1101/2022.10.04.510869
https://doi.org/10.1101/2022.10.04.510869
Autor:
Aparna Bhaduri, Madeline G. Andrews, Jayden M. Ross, Arnold R. Kriegstein, Mark-Phillip Pebworth
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 26
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
Studies of the spatiotemporal, transcriptomic, and morphological diversity of radial glia (RG) have spurred our current models of human corticogenesis. In the developing cortex, neural intermediate progenitor cells (nIPCs) are a neuron-producing tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74462dfa3a41486f0254317fac4d1b4
https://escholarship.org/uc/item/3tc831xw
https://escholarship.org/uc/item/3tc831xw
Autor:
Arnold R. Kriegstein, Ming Hu, Ugomma C. Eze, Michael Song, Changxu Fan, Ian Jones, Ivan Juric, Lenka Maliskova, Yin Shen, Mayank N. K. Choudhary, Ting Wang, Jerry Lee, Bingkun Li, Seth Bergenholtz, Mark-Phillip Pebworth, Jia Wen, Yun Li, Armen Abnousi, Xiekui Cui, Weifang Liu, Alex A. Pollen, Jonathan D. Rosen, Xiaoyu Yang
Publikováno v:
Nature, vol 587, iss 7835
Nature
Nature
Lineage-specific epigenomic changes during human corticogenesis have remained elusive due to challenges with sample availability and tissue heterogeneity. For example, previous studies used single-cell RNA sequencing to identify at least nine major c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a644c262ff83307505111efd951970
https://escholarship.org/uc/item/9x4848qd
https://escholarship.org/uc/item/9x4848qd
Autor:
Xiekui Cui, Ivan Juric, Lenka Maliskova, Ian Jones, Michael Song, Yin Shen, Mayank N. K. Choudhary, Xin Yang, Bingkun Li, Ugomma C. Eze, Jonathan D. Rosen, Ming Hu, Alex A. Pollen, Weifang Liu, Jia Wen, Arnold R. Kriegstein, Armen Abnousi, Seth Bergenholtz, Changxu Fan, Ting Wang, Yun Li, Mark-Phillip Pebworth
Lineage-specific epigenomic changes during human corticogenesis have previously remained elusive due to challenges with tissue heterogeneity and sample availability. Here, we analyze cis-regulatory chromatin interactions, open chromatin regions, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b20ebc1da05b40777f5623c242801ad
Autor:
Yin Shen, Xiaoyu Yang, Arnold R. Kriegstein, Lenka Maliskova, Mark-Phillip Pebworth, Yun Li, Seth Bergenholtz
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 4, p e0228760 (2020)
PLoS ONE, Vol 15, Iss 4, p e0228760 (2020)
Accurate RNA quantification at the single-cell level is critical for understanding the dynamics of gene expression and regulation across space and time. Single molecule FISH (smFISH), such as RNAscope, provides spatial and quantitative measurements o
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110453 (2014)
PLoS ONE
PLoS ONE
Current studies investigating the role of biophysical cues on cell migration focus on the use of culture platforms with static material parameters. However, migrating cells in vivo often encounter spatial variations in extracellular matrix stiffness.