Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Mark-Anthony Bray"'
Autor:
Thomas C. Harper, Elaine M. Oberlick, Tomas J. Smith, Duncan E. Nunes, Mark-Anthony Bray, Seonmi Park, Corey D. Driscoll, Sarah F. Mowbray, Christophe Antczak
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107804- (2023)
Summary: Human pluripotent stem cell (hPSC)-derived tissues can be used to model diseases in cell types that are challenging to harvest and study at-scale, such as neutrophils. Neutrophil dysregulation, specifically neutrophil extracellular trap (NET
Externí odkaz:
https://doaj.org/article/07704c9616f94ef081d1421a043c811f
Autor:
Evgeny Shlevkov, Himanish Basu, Mark-Anthony Bray, Zheng Sun, Wei Wei, Kaan Apaydin, Kyle Karhohs, Pin-Fang Chen, Janell L.M. Smith, Ole Wiskow, Kasper Roet, Xuan Huang, Kevin Eggan, Anne E. Carpenter, Robin J. Kleiman, Thomas L. Schwarz
Publikováno v:
Cell Reports, Vol 28, Iss 12, Pp 3224-3237.e5 (2019)
Summary: Dysregulated axonal trafficking of mitochondria is linked to neurodegenerative disorders. We report a high-content screen for small-molecule regulators of the axonal transport of mitochondria. Six compounds enhanced mitochondrial transport i
Externí odkaz:
https://doaj.org/article/914ac8b6b6974b42ac32cfd413e51640
Autor:
Amy K Barczak, Roi Avraham, Shantanu Singh, Samantha S Luo, Wei Ran Zhang, Mark-Anthony Bray, Amelia E Hinman, Matthew Thompson, Raymond M Nietupski, Aaron Golas, Paul Montgomery, Michael Fitzgerald, Roger S Smith, Dylan W White, Anna D Tischler, Anne E Carpenter, Deborah T Hung
Publikováno v:
PLoS Pathogens, Vol 13, Iss 5, p e1006363 (2017)
A key to the pathogenic success of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, is the capacity to survive within host macrophages. Although several factors required for this survival have been identified, a comprehensive kn
Externí odkaz:
https://doaj.org/article/8b50f29d4ea94e029d1bb15d808763c6
Autor:
Mohammad Hossein Rohban, Shantanu Singh, Xiaoyun Wu, Julia B Berthet, Mark-Anthony Bray, Yashaswi Shrestha, Xaralabos Varelas, Jesse S Boehm, Anne E Carpenter
Publikováno v:
eLife, Vol 6 (2017)
We hypothesized that human genes and disease-associated alleles might be systematically functionally annotated using morphological profiling of cDNA constructs, via a microscopy-based Cell Painting assay. Indeed, 50% of the 220 tested genes yielded d
Externí odkaz:
https://doaj.org/article/4b1fa733fade44f5a01af4c26686b74a
Autor:
Yakov Chudnovsky, Dohoon Kim, Siyuan Zheng, Warren A. Whyte, Mukesh Bansal, Mark-Anthony Bray, Shuba Gopal, Matthew A. Theisen, Steve Bilodeau, Prathapan Thiru, Julien Muffat, Omer H. Yilmaz, Maya Mitalipova, Kevin Woolard, Jeongwu Lee, Riko Nishimura, Nobuo Sakata, Howard A. Fine, Anne E. Carpenter, Serena J. Silver, Roel G.W. Verhaak, Andrea Califano, Richard A. Young, Keith L. Ligon, Ingo K. Mellinghoff, David E. Root, David M. Sabatini, William C. Hahn, Milan G. Chheda
Publikováno v:
Cell Reports, Vol 6, Iss 2, Pp 313-324 (2014)
Glioblastoma (GBM) harbors subpopulations of therapy-resistant tumor-initiating cells (TICs) that are self-renewing and multipotent. To understand the regulation of the TIC state, we performed an image-based screen for genes regulating GBM TIC mainte
Externí odkaz:
https://doaj.org/article/ec2905833cc54c5e82b2fee25ecd2d48
Autor:
Shantanu Singh, Xiaoyun Wu, Vebjorn Ljosa, Mark-Anthony Bray, Federica Piccioni, David E Root, John G Doench, Jesse S Boehm, Anne E Carpenter
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131370 (2015)
RNA interference and morphological profiling-the measurement of thousands of phenotypes from individual cells by microscopy and image analysis-are a potentially powerful combination. We show that morphological profiles of RNAi-induced knockdown using
Externí odkaz:
https://doaj.org/article/52406d862e204a53b0c2d076f7e0b51a
Autor:
Sarah A Stanley, Amy K Barczak, Melanie R Silvis, Samantha S Luo, Kimberly Sogi, Martha Vokes, Mark-Anthony Bray, Anne E Carpenter, Christopher B Moore, Noman Siddiqi, Eric J Rubin, Deborah T Hung
Publikováno v:
PLoS Pathogens, Vol 10, Iss 2, p e1003946 (2014)
Mycobacterium tuberculosis remains a significant threat to global health. Macrophages are the host cell for M. tuberculosis infection, and although bacteria are able to replicate intracellularly under certain conditions, it is also clear that macroph
Externí odkaz:
https://doaj.org/article/5b406ec88de142fa943bed895dc1f3bd
Autor:
Anna Grosberg, Po-Ling Kuo, Chin-Lin Guo, Nicholas A Geisse, Mark-Anthony Bray, William J Adams, Sean P Sheehy, Kevin Kit Parker
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 2, p e1001088 (2011)
The organization of muscle is the product of functional adaptation over several length scales spanning from the sarcomere to the muscle bundle. One possible strategy for solving this multiscale coupling problem is to physically constrain the muscle c
Externí odkaz:
https://doaj.org/article/f8428b0397254601a1f6926d0abcb124
Autor:
Mark-Anthony Bray, Antoine de Weck, Eric Durand, Jian Fang, Daniela Gabriel, Rens Janssens, Ioannis Moutsatsos, Stephan Spiegel, Xian Zhang
Recent development of novel methods based on deep neural networks has transformed how high-content microscopy cellular images are analyzed. Nonetheless, it is still a challenge to identify cellular phenotypic changes caused by chemical or genetic tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89c7a8e180099c0a14b92c66f240460a
https://doi.org/10.1101/2022.05.15.491989
https://doi.org/10.1101/2022.05.15.491989
Autor:
Federica Piccioni, Cathy L Hartland, Angela N. Brooks, Juan C. Caicedo, Xiaoyun Wu, Anne E. Carpenter, Shantanu Singh, John Arevalo, Mark-Anthony Bray, Alice H. Berger, Jesse S. Boehm
Publikováno v:
Molecular biology of the cell. 33(6)
Most variants in most genes across most organisms have an unknown impact on the function of the corresponding gene. This gap in knowledge is especially acute in cancer, where clinical sequencing of tumors now routinely reveals patient-specific varian