Výsledky vyhledávání - "Mark de Serres"

Central Nervous System Disposition and Metabolism of Fosdevirine (GSK2248761), a Non-Nucleoside Reverse Transcriptase Inhibitor: An LC-MS and Matrix-Assisted Laser Desorption/Ionization Imaging MS Investigation into Central Nervous System Toxicity

Autor: James Myer, J. Sigafoos, David S. Wagner, Mark de Serres, M. Reid Groseclose, Joseph W. Polli, Stephen Castellino, Elizabeth Romach, Brad Hamilton

Publikováno v: Chemical Research in Toxicology. 26:241-251

The CNS disposition and metabolism of Fosdevirine (FDV), an HIV non-nucleoside reverse transcriptase inhibitor, was investigated in four patients who unexpectedly experienced seizures after at least 4 weeks of treatment in a Phase IIb, HIV-1 treatmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef747466d2667d6218609e7a511ab1b7
https://doi.org/10.1021/tx3004196

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Drug interaction profile for GSK2248761, a next generation non-nucleoside reverse transcriptase inhibitor

Autor: Steve Piscitelli, Mark Johnson, Xiao-Jian Zhou, J. Kim, Elizabeth Gould, Keith Pietropaolo, Scott White, Douglas L. Mayers, Yu Lou, Mark de Serres

Publikováno v: British Journal of Clinical Pharmacology. 74:336-345

AIM To evaluate potential drug interactions with antiretroviral therapies or supportive therapies for use in conjunction with the once daily, next generation non-nucleoside reverse transcriptase inhibitor GSK2248761 in patients with HIV-1 infection.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5bd4266bf3cd7617b30233761892512a
https://doi.org/10.1111/j.1365-2125.2012.04194.x

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Morphologic Characterization of PhoenixBio® (uPA+/+/SCID) Humanized Liver Chimeric Mouse Model

Autor: Mark de Serres, H. Roger Brown, Richard A. Peterson, David Krull

Publikováno v: Drug Metabolism Letters. 4:180-184

Morphological evaluation of humanized chimeric mouse livers from the PhoenixBio (uPA(+/+)/SCID) mouse model show robust replacement and expansion with human hepatocytes, however areas of human hepatocytes had prominent steatosis and a variable lack o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a88e75ce984179bbb4c1b3481d98483
https://doi.org/10.2174/187231210791698456

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The disposition and metabolism of GW695634: A non-nucleoside reverse transcriptase inhibitor (NNRTi) for treatment of HIV/AIDS

Autor: Lee Moss, Cosette J. Serabjit-Singh, Andrea M. Sefler, J. Sigafoos, Mark de Serres, Stephen Castellino, Gary D Bowers

Publikováno v: Xenobiotica. 40:437-445

GW695634 is the prodrug of GW678248, a novel non-nucleoside reverse transcriptase inhibitor with potent antiviral activity against HIV/AIDS efavirenz- and nevirapine-resistant viruses. In mice, rats, and monkeys following oral administration of [(14)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f01a8e957a82d7f8b9707c9d1ae8ca6
https://doi.org/10.3109/00498251003770578

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Immunogenicity of Thrombopoietin Mimetic Peptide GW395058 in BALB/c Mice and New Zealand White Rabbits: Evaluation of the Potential for Thrombopoietin Neutralizing Antibody Production in Man

Autor: Byron Ellis, Debra Weigl, Jeff T. Hutchins, Mark de Serres, Randolph B. DePrince, John E. Dillberger, Sharon K. Rudolph, Christine M. Boytos

Publikováno v: STEM CELLS. 17:203-209

Administration of exogenous proteins and peptides as therapeutics carries with it the potential for immune system recognition and the development of neutralizing antibodies to endogenous regulatory proteins. PEGylation of proteins typically reduces t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a9781d3c6ff73d43af74cc08030aac9
https://doi.org/10.1002/stem.170203

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Evaluation of a chimeric (uPA+/+)/SCID mouse model with a humanized liver for prediction of human metabolism

Autor: David S. Wagner, Vishal Shah, J. Sigafoos, Russell L. Yeager, Steve Castellino, Gary D Bowers, Gary Boyle, Mark de Serres, Andrew D. Roberts, Mehul Dave, Claire Beaumont, Katie L Olson, Cosette J. Serabjit-Singh, Dipak K. Patel

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 41(6)

A model that predicts human metabolism and disposition of drug candidates would be of value in early drug development. In this study, a chimeric (uPA+/+)/SCID mouse model was evaluated with three structurally distinct compounds (GW695634, a benzophen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b867347211a6031ba99a038aebc58bb
https://pubmed.ncbi.nlm.nih.gov/21370990

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Assessment of cryopreserved hepatocytes as an alternative to fresh hepatocytes for comparative interspecies metabolism studies with suitable acceptance criteria

Autor: Christine E Herron, Gary D Bowers, Ziqiang Zack Cheng, Mark de Serres

Publikováno v: Drug metabolism letters. 1(2)

Fresh hepatocytes have been the choice for interspecies comparative drug metabolism studies. Cryopreserved hepatocytes represent a readily available alternative when combined with acceptance limits based on the metabolic turnover of 7-ethoxycoumarin.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b7a67795836d5d2ee660798b3129340
https://pubmed.ncbi.nlm.nih.gov/19356029

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The pharmacokinetics and pharmacodynamics of GW395058, a peptide agonist of the thrombopoietin receptor, in the dog, a large-animal model of chemotherapy-induced thrombocytopenia

Autor: Beth Case, John E. Dillberger, Mark de Serres, Marlene L. Hauck, Anita H. Simkins, Russell L. Yeager, Virginia D. Schmith, Rodney L. Page

Publikováno v: Stem cells (Dayton, Ohio). 18(5)

GW395058, a PEGylated peptide agonist of the thrombopoietin receptor, stimulates megakaryocytopoiesis and has previously been shown to increase platelet counts in vivo. The pharmacokinetics and pharmacodynamics of GW395058 were characterized using a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c750d8ed0c6e22e437b4eda57733dca8
https://pubmed.ncbi.nlm.nih.gov/11007920

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Pharmacokinetics and hematological effects of the PEGylated thrombopoietin peptide mimetic GW395058 in rats and monkeys after intravenous or subcutaneous administration

Autor: Mark de Serres, John E. Dillberger, Jeffry M. Sailstad, M. J. Mcnulty, Anita H. Simkins, Guy H. Gardner, Cathleen A. Rubens, Guy Lalonde, Joseph L. Woolley, Russ L. Yeager

Publikováno v: Stem cells (Dayton, Ohio). 17(6)

GW395058, a potent PEGylated peptide human thrombopoietin receptor (HuTPOr) agonist in vitro, is being evaluated for the treatment of thrombocytopenia. GW395058 shares no sequence homology with TPO. In this report the pharmacokinetics and hematologic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48440dc1bf6ee18a2522282113ff58d3
https://pubmed.ncbi.nlm.nih.gov/10606160

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Development of a novel scintillation proximity competitive hybridization assay for the determination of phosphorothioate antisense oligonucleotide plasma concentrations in a toxicokinetic study

Autor: Gerald Zon, John W. A. Findlay, Mark de Serres, M. J. Mcnulty, Laura Christensen

Publikováno v: Analytical biochemistry. 233(2)

A novel scintillation proximity competitive hybridization assay was developed for determining plasma concentrations of compound 4003W94, a 15-base phosphorothioate antisense deoxyribonucleotide that is currently under preclinical evaluation for the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90668d1c76af9cd7389e49551a0e121f
https://pubmed.ncbi.nlm.nih.gov/8789723

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