Effects of Monoclonal Antibodies against Nerve Growth Factor on Healthy Bone and Joint Tissues in Mice, Rats, and Monkeys: Histopathologic, Biomarker, and Microcomputed Tomographic Assessments

Autor: Susan Hurst, Cedo M. Bagi, Mark Zorbas, William J. Reagan, Mark G. Evans, Kathryn E. Gropp, Cathy S. Carlson, David L. Shelton

Publikováno v: Toxicologic Pathology. 46:408-420

Tanezumab, an anti-nerve growth factor (NGF) antibody, is in development for management of chronic pain. During clinical trials of anti-NGF antibodies, some patients reported unexpected adverse events requiring total joint replacements, resulting in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4642fcbc6e8f570aa32349e69b8df3
https://doi.org/10.1177/0192623318772501

Anti-NGF monoclonal antibody muMab 911 does not deplete neurons in the superior cervical ganglia of young or old adult rats

Autor: Chang-Ning Liu, Carlin Okerberg, Chris J. Somps, Paul Butler, Peter R. Mouton, Mark Zorbas, Jens R. Nyengaard, Magalie Boucher, John M. Marcek, David M. Potter

Publikováno v: Marcek, J, Okerberg, C, Liu, C-N, Potter, D, Butler, P, Boucher, M, Zorbas, M, Mouton, P, Nyengaard, J R & Somps, C 2016, ' Anti-NGF monoclonal antibody muMab 911 does not deplete neurons in the superior cervical ganglia of young or old adult rats ', Journal of Chemical Neuroanatomy, vol. 76, no. part B, pp. 133-141 . https://doi.org/10.1016/j.jchemneu.2016.05.007

Nerve growth factor (NGF) blocking therapies are an emerging and effective approach to pain management. However, concerns about the potential for adverse effects on the structure and function of the peripheral nervous system have slowed their develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd51c14e007932b4680bf243e7e976c7
https://doi.org/10.1016/j.jchemneu.2016.05.007

Developmental toxicity assessment of tanezumab, an anti-nerve growth factor monoclonal antibody, in cynomolgus monkeys (Macaca fascicularis)

Autor: Jessica-lyn Gremminger, Christopher J. Bowman, Thomas Cummings, David L. Shelton, Mark Zorbas, Satoru Oneda, Susan Hurst, Cris Kamperschroer, Mark G. Evans, Mark Butt

Publikováno v: Reproductive Toxicology. 53:105-118

Two intravenous studies with tanezumab, an anti-nerve growth factor monoclonal antibody, were conducted in pregnant cynomolgus monkeys to assess potential effects on pregnancy and pre- and postnatal development. Study 1 evaluated infants up to 12 mon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c80327a2139ccf2a66ec99382a49dd12
https://doi.org/10.1016/j.reprotox.2014.10.004

Choices and decisions: perspectives of young males on withdrawing from business certificate courses in technical and further education

Autor: Marnie O'Neill, Mark Zorbas, Anne Chapman

Publikováno v: University of Western Australia

This article reports research concerned with understanding the factors that influence the decision of young males to withdraw from their studies in certificate courses at a Technical and Further Education (TAFE) College in Western Australia. The rese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe3bff27792792045ab052cbeb71f4a
https://doi.org/10.1080/13596740500200199

Morphologic, stereologic, and morphometric evaluation of the nervous system in young cynomolgus monkeys (Macaca fascicularis) following maternal administration of tanezumab, a monoclonal antibody to nerve growth factor

Autor: Thomas Cummings, Mark Butt, Mark G. Evans, David L. Shelton, Satoru Oneda, Christopher J. Bowman, Mark Zorbas

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 142(2)

Tanezumab, an antibody to nerve growth factor, was administered to pregnant cynomolgus monkeys at 0, 0.5, 4, and 30 mg/kg weekly, beginning gestation day (GD) 20 through parturition (� GD165). Maternal tanezumab administration appeared to increase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51c8e4824e95fa69376d96022ffc66f
https://pubmed.ncbi.nlm.nih.gov/25326242