Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mark Zielstorff"'
Autor:
Kimberly Bettano, Mark Zielstorff, Raquel Sevilla, Ruojing Yang, Heather Zhou, Thomas Rosahl, Jie Zhang-Hoover, Lily Y. Moy, Weisheng Zhang
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 27, Iss , Pp 100781- (2022)
Cytotoxic CD8+ T cells are the primary effector cells mediating anti-tumor responses. In vivo monitoring of CD8+ T cells has broad implications for the development of novel cancer therapies. Here we describe the development of a genetically engineere
Externí odkaz:
https://doaj.org/article/91f1d11ab935479a80247794f6c32d0b
Autor:
Mark Zielstorff, Yiping Chen, Jeremy Presland, Alan Byford, Amy Doty, Erik Munsell, Craig Parish, Gretchen Baltus, Lily Moy, George Addona, Jie Zhang-Hoover
Publikováno v:
Cancer Research. 82:3143-3143
Activation of retinoic acid-inducible gene I (RIG-I) increases pro-inflammatory cytokine production, enhances antigen presentation, and promotes tumor cell apoptosis. Here we assessed the pharmacological activity of a RIG-I agonist encapsulated in li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5e10a485f6e8d7dd7babd8e92841a22
https://doi.org/10.1158/1538-7445.am2022-3143
https://doi.org/10.1158/1538-7445.am2022-3143
Autor:
Kimberly Bettano, Mark Zielstorff, Raquel Sevilla, Ruojing Yang, Heather Zhou, Thomas Rosahl, Jie Zhang-Hoover, Lily Y. Moy, Weisheng Zhang
Publikováno v:
Neoplasia (New York, N.Y.). 27
Cytotoxic CD8+ T cells are the primary effector cells mediating anti-tumor responses. In vivo monitoring of CD8+ T cells has broad implications for the development of novel cancer therapies. Here we describe the development of a genetically engineere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6038d7e98d1289d347787a501f1a65b
https://pubmed.ncbi.nlm.nih.gov/35381456
https://pubmed.ncbi.nlm.nih.gov/35381456
Autor:
Jiaqiang Cai, Bimjhana Bishwokarma, Dennis Leung, William J. Morris, Feroze Ujjainwalla, Candice Alleyne, Xiaoxing Du, Vincent J. Colandrea, Jennifer Piesvaux, Jianwu Bai, Liming Yang, Carla Alpert, Joseph M. Metzger, Vincenzo Pucci, Xiaofang Li, Jeffrey J. Hale, Dominique Stickens, Weiguo Quan, Byron G. DuBois, Rongqiang Liu, Mark Zielstorff, Chi-Sung Chiu, Christopher Joseph Sinz, Mangeng Cheng, Kallol Ray, Liping Wang, Ping Liu, Stella H. Vincent, Alejandro Crespo
Publikováno v:
ACS Medicinal Chemistry Letters. 9:1193-1198
[Image: see text] We report herein the design and synthesis of a series of orally active, liver-targeted hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitors for the treatment of anemia. In order to mitigate the concerns for potential sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76215d13beffa00c0fc7a79f728fdec
https://doi.org/10.1021/acsmedchemlett.8b00274
https://doi.org/10.1021/acsmedchemlett.8b00274
Autor:
Jeffrey T. Borenstein, Daniel Doty, Troy Lau, John R. Chevillet, Alla A. Gimbel, Lily Y. Moy, Nathan Moore, N. Lowry, Vienna L. Mott, Hongmin Chen, Jose A. Santos, G. Addona, Ilona Kariv, Mark Zielstorff, Louis B. Kratchman
Publikováno v:
Lab on a Chip. 18:1844-1858
Recapitulation of the tumor microenvironment is critical for probing mechanisms involved in cancer, and for evaluating the tumor-killing potential of chemotherapeutic agents, targeted therapies and immunotherapies. Microfluidic devices have emerged a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ec1a09aea06fdd034af31c2d93535d
https://doi.org/10.1039/c8lc00256h
https://doi.org/10.1039/c8lc00256h
Autor:
Juhi Firdos, Kern Jeffrey, Dennis M. Zaller, Douglas Hodges, Laurence Fayadat-Dilman, Isabel Figueroa, Shuli Zhang, Anthony Manibusan, Peter Stivers, Lily Y. Moy, Hyun Chong Woo, Yiwei Zhang, Nickolas Knudsen, Philip E. Brandish, Laura Garvin-Queen, Svetlana Antonenko, Kristen Kwasnjuk, Daniela M. Tomazela, Prasanthi Geda, SuChun Hseih, Mark T. Cancilla, Sanjiv J. Shah, Robert M. Garbaccio, Maribel Beaumont, John H. Shin, Lia Benso, Dennis Gately, Huiping Ma, Christopher Haines, Mangeng Cheng, Paul L. Miller, Mark Zielstorff, Linda Liang, Anthony Palmieri, Ying Sun, Guo Feng, Yujie Qu
Publikováno v:
Bioconjugate chemistry. 29(7)
Glucocorticoids (GCs) are excellent anti-inflammatory drugs but are dose-limited by on-target toxicity. We sought to solve this problem by delivering GCs to immune cells with antibody-drug conjugates (ADCs) using antibodies containing site-specific i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7229ec9a33f21a3683f44ccad95f70dc
https://pubmed.ncbi.nlm.nih.gov/29923706
https://pubmed.ncbi.nlm.nih.gov/29923706
Autor:
John Miao, Belma Dogdas, Francisco Cruz, Gain M. Robinson, Amy Vanko, Robert Faltus, Kalyan Chakravarthy, Dahai Xue, Chi-Sung Chiu, Mark Zielstorff, Donald V. Conway, Weisheng Zhang, Kimberly A. Bettano, Joe Zhu, Shubing Wang, Milenko Cicmil, Lily Y. Moy, Raquel S. Sevilla, Erica Leccese
Publikováno v:
Bone. 73:32-41
Rheumatoid arthritis (RA) is a chronic autoimmune disease resulting in joint inflammation, pain, and eventual bone loss. Bone loss and remodeling caused by symmetric polyarthritis, the hallmark of RA, is readily detectable by bone mineral density (BM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3607b859e5ef8c19b40b23be9af25d
Autor:
Peter J. Dandliker, Hao Tang, Christopher J. Dinsmore, Chi-Sung Chiu, Fiona Elwood, Deborah Slipetz, Jennifer Piesvaux, Sujal V. Deshmukh, Ilona Kariv, Bo-Sheng Pan, Carla Alpert, Nathan Bays, Alan Byford, Alexey Rivkin, Peter Goldenblatt, Irena Ivanovska, Mark E. Scott, Joel A. Klappenbach, Hyun-Hee Lee, David J. Witter, Kalyan Chakravarthy, Lauren Dorosh, Yujie Qu, Brian Kraybill, Mark Zielstorff
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 361(2)
Reversible janus associated kinase (JAK) inhibitors such as tofacitinib and decernotinib block cytokine signaling and are efficacious in treating autoimmune diseases. However, therapeutic doses are limited due to inhibition of other JAK/signal transd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30dcce0e8183db5060a7c6ebeec57fe3
https://pubmed.ncbi.nlm.nih.gov/28193636
https://pubmed.ncbi.nlm.nih.gov/28193636
Autor:
Shuli Zhang, Dana A. Stoffregen, Anwar Murtaza, Mark Zielstorff, Weisheng Zhang, Jie Zhang-Hoover, Erica Leccese, Michael Caniga, Robert Faltus, Milenko Cicmil, Lily Y. Moy, John H. Shin, SuChun Hseih, Raquel S. Sevilla, Chi-Sung Chiu, Gain M. Robinson, Kalyan Chakravarthy, Robbie L. McLeod, Alan Byford
Publikováno v:
BMC Musculoskeletal Disorders
Background The impact of anti-TNF, corticosteroid and analgesic therapy on inflammation and pain was evaluated in a novel mono-arthritic multi-flare rat Streptococcal Cell Wall (SCW) model using Etanercept, Dexamethasone and Buprenorphine. Methods Mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e61363f56f35788b58ee6945901996
https://doi.org/10.1186/1471-2474-15-409
https://doi.org/10.1186/1471-2474-15-409
Autor:
Robinson, Gain, Zielstorff, Mark, Sevilla, Raquel, Vanko, Amy, Sinz, Christopher, Cicmil, Milenko, Zhang, Weisheng, Bettano, Kimberly
Publikováno v:
Molecular Imaging & Biology; Feb2024, Vol. 26 Issue 1, p188-188, 1p