Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Mark Z Kos"'
Autor:
Melanie A Carless, Hemant Kulkarni, Mark Z Kos, Jac Charlesworth, Juan M Peralta, Harald H H Göring, Joanne E Curran, Laura Almasy, Thomas D Dyer, Anthony G Comuzzie, Michael C Mahaney, John Blangero
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73950 (2013)
Several studies have identified effects of genetic variation on DNA methylation patterns and associated heritability, with research primarily focused on Caucasian individuals. In this paper, we examine the evidence for genetic effects on DNA methylat
Externí odkaz:
https://doaj.org/article/58b965aa90ac448085f1100a57d42f75
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
IntroductionBipolar disorder (BD) is a chronic mental illness characterized by recurrent episodes of mania and depression and associated with social and cognitive disturbances. Environmental factors, such as maternal smoking and childhood trauma, are
Externí odkaz:
https://doaj.org/article/dd40fece4cae47c2b57f620b01aea5b5
Autor:
Mark Z. Kos, Melanie A. Carless, Lucy Blondell, M. Michelle Leland, Koyle D. Knape, Harald H. H. Göring, Charles Ákos Szabó
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
In this study, we investigate the genetic determinants that underlie epilepsy in a captive baboon pedigree and evaluate the potential suitability of this non-human primate model for understanding the genetic etiology of human epilepsy. Archived whole
Externí odkaz:
https://doaj.org/article/ea7bcb588835406e8f7b81932b91751b
Publikováno v:
Algorithms, Vol 14, Iss 10, p 296 (2021)
Statistical analysis of multinomial data in complex datasets often requires estimation of the multivariate normal (mvn) distribution for models in which the dimensionality can easily reach 10–1000 and higher. Few algorithms for estimating the mvn d
Externí odkaz:
https://doaj.org/article/1ab7ff38f8a0415aabbd0c9b3fb91717
Autor:
Eugene Drigalenko, Melanie A. Carless, Mark Z. Kos, Pablo V. Gejman, Jubao Duan, Alan R. Sanders, Mgs, Harald H H Göring, Lucy Blondell
Publikováno v:
Translational Psychiatry, Vol 8, Iss 1, Pp 1-14 (2018)
Translational psychiatry, vol 8, iss 1
Translational Psychiatry
Translational psychiatry, vol 8, iss 1
Translational Psychiatry
The dopaminergic hypothesis of schizophrenia (SZ) postulates that positive symptoms of SZ, in particular psychosis, are due to disturbed neurotransmission via the dopamine (DA) receptor D2 (DRD2). However, DA is a reactive molecule that yields variou
Autor:
Inmaculada del Rincón, Satish Kumar, Agustín Escalante, Marcio Almeida, John Blangero, Mark Z. Kos, Vidya S. Farook, José Félix Restrepo, Rector Arya, Christopher P. Jenkinson, Ravindranath Duggirala, Joanne E. Curran, Srinivas Mummidi, Marcel J. Fourcaudot, Daniel F. Battafarano
Publikováno v:
Data in Brief
Data in Brief, Vol 17, Iss, Pp 820-829 (2018)
Data in Brief, Vol 17, Iss, Pp 820-829 (2018)
Carotid Intima-media thickness (CIMT) and plaque are well established markers of subclinical atherosclerosis and are widely used for identifying subclinical atherosclerotic disease. We performed association analyses using Metabochip array to identify
Autor:
Rector Arya, Vidya S. Farook, Inmaculada del Rincón, John Blangero, José Félix Restrepo, Christopher P. Jenkinson, Marcio Almeida, Satish Kumar, Srinivas Mummidi, Joanne E. Curran, Mark Z. Kos, Daniel F. Battafarano, Marcel J. Fourcaudot, Agustín Escalante, Ravindranath Duggirala
Publikováno v:
Atherosclerosis. 271:92-101
BACKGROUND AND AIMS: Little is known about specific genetic determinants of carotid-intima-media thickness (CIMT) and carotid plaque in subjects with rheumatoid arthritis (RA). We have used the Metabochip array to fine map and replicate loci that inf
Publikováno v:
Human Heredity. 83:92-99
Objectives: An interesting consequence of consanguinity is that the inbred singleton becomes informative for genetic variance. We determine the contribution of an inbred singleton to variance component analysis of heritability and linkage. Methods: S
Autor:
David R. Roalf, August Blackburn, Ruben C. Gur, Melanie A. Carless, Juan M. Peralta, Marcio Almeida, Harald H H Göring, Vishwajit L. Nimgaonkar, Raquel E. Gur, Michael F. Pogue-Geile, Lucy Blondell, Mark Z. Kos, Ellen E. Quillen, Laura Almasy, Joanne E. Curran
Publikováno v:
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 174:817-827
Schizophrenia is a serious mental illness, involving disruptions in thought and behavior, with a worldwide prevalence of about one percent. Although highly heritable, much of the genetic liability of schizophrenia is yet to be explained. We searched
Autor:
Mark Z. Kos, Donna M. Lehman, Harald H H Göring, Peter T Stevens, Nicholas B. Blackburn, August Blackburn, Juan M. Peralta, Lucy Blondell, John Blangero
Publikováno v:
Eur J Hum Genet
Phasing is the process of inferring haplotypes from genotype data. Efficient algorithms and associated software for accurate phasing in pedigrees are needed, especially for populations lacking reference panels of sequenced individuals. We present a n