Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Mark Yarmarkovich"'
Autor:
Guillem Pascual-Pasto, Brendan McIntyre, Margaret G. Hines, Anna M. Giudice, Laura Garcia-Gerique, Jennifer Hoffmann, Pamela Mishra, Stephanie Matlaga, Simona Lombardi, Rawan Shraim, Patrick M. Schürch, Mark Yarmarkovich, Ted J. Hofmann, Fatemeh Alikarami, Daniel Martinez, Matthew Tsang, Luis Gil-de-Gómez, Timothy T. Spear, Kathrin M. Bernt, Adam J. Wolpaw, Dimiter S. Dimitrov, Wei Li, Kristopher R. Bosse
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Novel chimeric antigen receptor (CAR) T-cell approaches are needed to improve therapeutic efficacy in solid tumors. High-risk neuroblastoma is an aggressive pediatric solid tumor that expresses cell-surface GPC2 and GD2 with a tumor microenv
Externí odkaz:
https://doaj.org/article/b2ad4e5f753a46548b7df6730192b457
Autor:
Sarah A. Overall, Jugmohit S. Toor, Stephanie Hao, Mark Yarmarkovich, Sara M. O’Rourke, Giora I. Morozov, Son Nguyen, Alberto Sada Japp, Nicolas Gonzalez, Danai Moschidi, Michael R. Betts, John M. Maris, Peter Smibert, Nikolaos G. Sgourakis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Peptide-MHC (pMHC) tetramers are important tools for probing T cell repertoire and adaptive immune responses. Here the authors use a molecular chaperone, TAPBPR, to develop a high-throughput, multiplexible platform for pMHC tetramer generation to fac
Externí odkaz:
https://doaj.org/article/975b9e150895476f87a40ab18d6ce573
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 3, Pp 100036- (2020)
Summary: Here we propose a SARS-CoV-2 vaccine design concept based on identification of highly conserved regions of the viral genome and newly acquired adaptations, both predicted to generate epitopes presented on major histocompatibility complex (MH
Externí odkaz:
https://doaj.org/article/97c9aa059a124d5dbb6e002449261e5d
Autor:
Mark Yarmarkovich, Alvin Farrel, Artemio Sison, Moreno di Marco, Pichai Raman, Joshua L. Parris, Dimitrios Monos, Hongzhe Lee, Stefan Stevanovic, John M. Maris
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Despite recent advances in cancer immunotherapy, the process of immunoediting early in tumorigenesis remains obscure. Here, we employ a mathematical model that utilizes the Cancer Genome Atlas (TCGA) data to elucidate the contribution of individual m
Externí odkaz:
https://doaj.org/article/09182b717673491e810b88ccf230e15c
Autor:
Jugmohit S. Toor, Arjun A. Rao, Andrew C. McShan, Mark Yarmarkovich, Santrupti Nerli, Karissa Yamaguchi, Ada A. Madejska, Son Nguyen, Sarvind Tripathi, John M. Maris, Sofie R. Salama, David Haussler, Nikolaos G. Sgourakis
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The identification of recurrent human leukocyte antigen (HLA) neoepitopes driving T cell responses against tumors poses a significant bottleneck in the development of approaches for precision cancer therapeutics. Here, we employ a bioinformatics meth
Externí odkaz:
https://doaj.org/article/7cab667e25c5456084b2a5b3c7e53a5a
Autor:
Yi Sun, Tyler J. Florio, Sagar Gupta, Michael C. Young, Quinlen F. Marshall, Samuel E. Garfinkle, Georgia F. Papadaki, Hau V. Truong, Emily Mycek, Peiyao Li, Alvin Farrel, Nicole L. Church, Shereen Jabar, Matthew D. Beasley, Ben R. Kiefel, Mark Yarmarkovich, Leena Mallik, John M. Maris, Nikolaos G. Sgourakis
Publikováno v:
bioRxiv
Peptide-Centric Chimeric Antigen Receptors (PC-CARs), which recognize oncoprotein epitopes displayed by human leukocyte antigens (HLAs) on the cell surface, offer a promising strategy for targeted cancer therapy1. We have previously developed a PC-CA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b864fd11df8e25bd1fa0f7574a90f1f1
https://europepmc.org/articles/PMC10245919/
https://europepmc.org/articles/PMC10245919/
Autor:
Andrea Califano, John M. Maris, Jose M. Silva, Anna Lasorella, Antonio Iavarone, Richard A. Young, A. Thomas Look, Rogier Versteeg, Pieter Mestdagh, Jo Vandesompele, Javed Khan, Jun S. Wei, Robert C. Seeger, Shahab Asgharzadeh, Jan Koster, Katleen De Preter, Derek Oldridge, Jo Lynne Harenza, Archana Iyer, Mariano J. Alvarez, Brian J. Abraham, Nina Weichert-Leahey, Mark Yarmarkovich, Daniel Martinez, Ruth Rodriguez-Barrueco, Jiyang Yu, Beatrice Salvatori, Claudia Capdevila, Gonzalo Lopez, Presha Rajbhandari
ARACNe-AP transcriptional network from gene expression profiles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed2bc5b35a3c8122c8650ca5e94b3cf
https://doi.org/10.1158/2159-8290.22532683
https://doi.org/10.1158/2159-8290.22532683
Autor:
Andrea Califano, John M. Maris, Jose M. Silva, Anna Lasorella, Antonio Iavarone, Richard A. Young, A. Thomas Look, Rogier Versteeg, Pieter Mestdagh, Jo Vandesompele, Javed Khan, Jun S. Wei, Robert C. Seeger, Shahab Asgharzadeh, Jan Koster, Katleen De Preter, Derek Oldridge, Jo Lynne Harenza, Archana Iyer, Mariano J. Alvarez, Brian J. Abraham, Nina Weichert-Leahey, Mark Yarmarkovich, Daniel Martinez, Ruth Rodriguez-Barrueco, Jiyang Yu, Beatrice Salvatori, Claudia Capdevila, Gonzalo Lopez, Presha Rajbhandari
High-risk neuroblastomas show a paucity of recurrent somatic mutations at diagnosis. As a result, the molecular basis for this aggressive phenotype remains elusive. Recent progress in regulatory network analysis helped us elucidate disease-driving me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ec33e6900439e695920cb9351cfda9
https://doi.org/10.1158/2159-8290.c.6546793.v1
https://doi.org/10.1158/2159-8290.c.6546793.v1
Autor:
Andrea Califano, John M. Maris, Jose M. Silva, Anna Lasorella, Antonio Iavarone, Richard A. Young, A. Thomas Look, Rogier Versteeg, Pieter Mestdagh, Jo Vandesompele, Javed Khan, Jun S. Wei, Robert C. Seeger, Shahab Asgharzadeh, Jan Koster, Katleen De Preter, Derek Oldridge, Jo Lynne Harenza, Archana Iyer, Mariano J. Alvarez, Brian J. Abraham, Nina Weichert-Leahey, Mark Yarmarkovich, Daniel Martinez, Ruth Rodriguez-Barrueco, Jiyang Yu, Beatrice Salvatori, Claudia Capdevila, Gonzalo Lopez, Presha Rajbhandari
Supplementary Experimental Procedures; Supplementary Figures S1-S10; Supplementary Table Legends S1-S9; Supplementary Tables S8-S9; Additional References
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::510859e6d31e031c2e7949ef46fefed1
https://doi.org/10.1158/2159-8290.22532692
https://doi.org/10.1158/2159-8290.22532692
Autor:
Kristopher R. Bosse, Laurence C. Eisenlohr, Nikolaos G. Sgourakis, Nathan M. Kendsersky, Rasika Premaratne, David Groff, Helena Shen, Daniel Martinez, Sarvind Tripathi, Tiffany Noel, John M. Maris, Rebecca Weisberg, Son Nguyen, Jugmohit S. Toor, Mark Yarmarkovich, John M. Warrington, Nicole L. Church, Stefan Stevanovic, Quinlen F. Marshall, Ben R. Kiefel, Erin Runbeck, Hau Truong, Alvin Farrel, Wei Li, Amber K. Weiner, Molly Christie, Moreno Di Marco, Dimiter S. Dimitrov
Publikováno v:
Nature
The majority of oncogenic drivers are intracellular proteins, thus constraining their immunotherapeutic targeting to mutated peptides (neoantigens) presented by individual human leukocyte antigen (HLA) allotypes1. However, most cancers have a modest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25f966b7592f801ab9df0ade95e369fc
https://doi.org/10.1038/s41586-021-04061-6
https://doi.org/10.1038/s41586-021-04061-6