Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Mark Y. Jeong"'
Autor:
Ying-Hsi Lin, Jennifer L. Major, Tim Liebner, Zaynab Hourani, Joshua G. Travers, Sara A. Wennersten, Korey R. Haefner, Maria A. Cavasin, Cortney E. Wilson, Mark Y. Jeong, Yu Han, Michael Gotthardt, Scott K. Ferguson, Amrut V. Ambardekar, Maggie P.Y. Lam, Chunaram Choudhary, Henk L. Granzier, Kathleen C. Woulfe, Timothy A. McKinsey
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)
Passive stiffness of the heart is determined largely by extracellular matrix and titin, which functions as a molecular spring within sarcomeres. Titin stiffening is associated with the development of diastolic dysfunction (DD), while augmented titin
Externí odkaz:
https://doaj.org/article/150af97ede814fce977a15aa3d27a1dc
Autor:
Josè Manuel Pioner, Alice W. Racca, Jordan M. Klaiman, Kai-Chun Yang, Xuan Guan, Lil Pabon, Veronica Muskheli, Rebecca Zaunbrecher, Jesse Macadangdang, Mark Y. Jeong, David L. Mack, Martin K. Childers, Deok-Ho Kim, Chiara Tesi, Corrado Poggesi, Charles E. Murry, Michael Regnier
Publikováno v:
Stem Cell Reports, Vol 6, Iss 6, Pp 885-896 (2016)
Summary: Tension production and contractile properties are poorly characterized aspects of excitation-contraction coupling of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Previous approaches have been limited due to the sma
Externí odkaz:
https://doaj.org/article/fcea7251262e4c4781ea99c51aaabcc4
Publikováno v:
The Permanente Journal. :1-10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4d0f53b4cd2fea4fe8297663b4ea198
https://doi.org/10.7812/tpp/22.135
https://doi.org/10.7812/tpp/22.135
Autor:
Joseph C. Cleveland, Angelo D'Alessandro, Michael R. Bristow, C. Y. Chi, Pilar Londono, Lori A. Walker, Mark Y. Jeong, Kunhua Song, Yuanbiao Zhao, Julie A. Reisz, Peter M. Buttrick, Genevieve C. Sparagna, Matthew R.G. Taylor, Benjamin C. Brown, Betty Bai, Yanmei Du, Kathleen C. Woulfe, Hongyan Xu, Timothy A. McKinsey, Amrut V. Ambardekar, Kathryn C. Chatfield, Ying-Hsi Lin, Walter E. Knight, Yingqiong Cao
Publikováno v:
Stem Cell Reports
Summary Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are a powerful platform for biomedical research. However, they are immature, which is a barrier to modeling adult-onset cardiovascular disease. Here, we sought to develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1064cc50cdfd444465c9047f47ac82
http://europepmc.org/articles/PMC7940251
http://europepmc.org/articles/PMC7940251
Autor:
William Schmidt, Timothy A. McKinsey, Anthony Cammarato, Ying H. Lin, D. Brian Foster, Mark Y. Jeong, Kristofer S. Fritz, Brandon J. Biesiadecki, Kathleen C. Woulfe
Publikováno v:
J Mol Cell Cardiol
Objective Cardiac troponin I (cTnI) is an essential physiological and pathological regulator of cardiac relaxation. Significant to this regulation, the post-translational modification of cTnI through phosphorylation functions as a key mechanism to ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35666669b6cc79ded9bfa91a0192dc13
https://doi.org/10.1016/j.yjmcc.2020.01.007
https://doi.org/10.1016/j.yjmcc.2020.01.007
Autor:
Timothy A. McKinsey, Amrut V. Ambardekar, Ying H. Lin, Hadi R. Ali, Joseph C. Cleveland, Kathleen C. Woulfe, Mark Y. Jeong, Kristofer S. Fritz, Cole R. Michel, Richard Reisdorph, Nichole Reisdorph
Publikováno v:
J Mol Cell Cardiol
Succinylation is a post-translational modification of protein lysine residues with succinyl groups derived from succinyl CoA. Succinylation is considered a significant post-translational modification with the potential to impact protein function whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8adecb78debe92ce875cb8cfc0a5d718
https://doi.org/10.1016/j.yjmcc.2019.11.159
https://doi.org/10.1016/j.yjmcc.2019.11.159
Autor:
Nathan J. Sniadecki, Kunhua Song, Michael A. Trembley, Eric M. Small, Peter M. Buttrick, Kevin M. Beussman, Andrea Leonard, Lori A. Walker, C. Y. Chi, Mark Y. Jeong, Walter E. Knight, Yuanbiao Zhao, Ellis Aune, Yingqiong Cao, Matthew R.G. Taylor, Pilar Londono, Hongyan Xu
Publikováno v:
Proceedings of the National Academy of Sciences. 116:556-565
Mutations in lysosomal-associated membrane protein 2 ( LAMP-2 ) gene are associated with Danon disease, which often leads to cardiomyopathy/heart failure through poorly defined mechanisms. Here, we identify the LAMP-2 isoform B (LAMP-2B) as required
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b331d7941938a4aaef0d54988e7f5f0
https://doi.org/10.1073/pnas.1808618116
https://doi.org/10.1073/pnas.1808618116
Autor:
Matthew R.G. Taylor, Yuanbiao Zhao, Kunhua Song, Peter M. Buttrick, Genevieve C. Sparagna, Betty Bai, Angelo D'Alessandro, Mark Y. Jeong, Timothy A. McKinsey, Lori A. Walker, Amrut V. Ambardekar, Joseph C. Cleveland, Julie A. Reisz, Yanmei Du, Kathleen C. Woulfe, C. Y. Chi, Hongyan Xu, Benjamin C. Brown, Michael R. Bristow, Kathryn C. Chatfield, Ying-Hsi Lin, Yingqiong Cao, Walter E. Knight, Pilar Londono
RationaleHuman induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) are a powerful platform for biomedical research. However, they are immature, which is a barrier to modeling adult-onset cardiovascular disease.ObjectiveWe sought to devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c0836cdfe1a75b082ae76b46670cec
https://doi.org/10.1101/2020.01.16.909598
https://doi.org/10.1101/2020.01.16.909598
Autor:
Marla R. Wolfson, Wolfgang F. Graier, Peter P. Rainer, Ying H. Lin, Timothy A. McKinsey, Jessica Pfleger, Sadia Mohsin, Jichuan Wu, Deborah M Eaton, Sandy T. Baker, Juergen Gindlhuber, Giulia Borghetti, Matthias Schittmayer, Mark Y. Jeong, Laura Liesinger, Sandra Blass, Andreas Zirlik, Huaqing Zhao, Steven R. Houser, Remus M. Berretta, Ruth Birner-Gruenberger, Markus Wallner, Dirk von Lewinski, Heiko Bugger
Publikováno v:
Sci Transl Med
Heart failure with preserved ejection fraction (HFpEF) is a major health problem without effective therapies. This study assessed the effects of histone deacetylase (HDAC) inhibition on cardiopulmonary structure, function, and metabolism in a large m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa790b6d29540a99efb30b5a1cd63c20
https://doi.org/10.1126/scitranslmed.aay7205
https://doi.org/10.1126/scitranslmed.aay7205
Autor:
Umair, Khalid, Lucas N, Marzec, Nicholas, Mantini, Spero M, Manson, Gheorghe, Doros, Christopher P, Cannon, Yang, Song, Liyan, Dong, Jonathan C, Hsu, Mark Y, Jeong, Salim S, Virani, Thomas M, Maddox
Publikováno v:
Journal of the American College of Cardiology. 75(21)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1702a402ff89c0e9b4ad7c6f8e5ec3d5
https://pubmed.ncbi.nlm.nih.gov/32466892
https://pubmed.ncbi.nlm.nih.gov/32466892