Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Mark Xiang Li"'
Autor:
Zheng Yuan, Mark F van Delft, Mark Xiang Li, Fransisca Sumardy, Brian J Smith, David C S Huang, Guillaume Lessene, Yelena Khakam, Ruitao Jin, Sitong He, Nicholas A Smith, Richard W Birkinshaw, Peter E Czabotar, Grant Dewson
Publikováno v:
PLoS Biology, Vol 22, Iss 5, p e3002617 (2024)
BAK and BAX execute intrinsic apoptosis by permeabilising the mitochondrial outer membrane. Their activity is regulated through interactions with pro-survival BCL-2 family proteins and with non-BCL-2 proteins including the mitochondrial channel prote
Externí odkaz:
https://doaj.org/article/91dcfa91babb4571a0a5c987ad54d99d
Autor:
Tobias Kratina, Ruth M. Kluck, Amber E. Alsop, Mark Xiang Li, Grant Dewson, Iris K. L. Tan, Michael A. Dengler, Colin Hockings, Stephen B. Ma
Publikováno v:
Proceedings of the National Academy of Sciences. 114:7629-7634
BAK and BAX are the essential effectors of apoptosis because without them a cell is resistant to most apoptotic stimuli. BAK and BAX undergo conformation changes to homooligomerize then permeabilize the mitochondrial outer membrane during apoptosis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc3a68f9f6a2e7b9d217a0b895f93ba
https://doi.org/10.1073/pnas.1702453114
https://doi.org/10.1073/pnas.1702453114
Autor:
Kristen Scicluna, Kerstin Brinkmann, Boris Reljic, Philippe Bouillet, Stephane Chappaz, Grant Dewson, Andrew P. Morokoff, Catherine Chang, Robert L Ninnis, Seong Lin Khaw, Laura F. Dagley, Ruth M. Kluck, Cathrine Hall, Andre L. Samson, Iris K. L. Tan, Gemma L. Kelly, Andrew I. Webb, Andrew J. Kueh, Marco J Herold, Daniel H.D. Gray, Hui San Chin, Michael T. Ryan, Mark F. van Delft, David C.S. Huang, Mark Xiang Li, Colin Hockings, Jarrod J. Sandow
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Nature Communications
Intrinsic apoptosis is critical to prevent tumor formation and is engaged by many anti-cancer agents to eliminate tumor cells. BAX and BAK, the two essential mediators of apoptosis, are thought to be regulated through similar mechanisms and act redun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d523948f8b15c950e0314f8d1870c4
https://doi.org/10.1038/s41467-018-07309-4
https://doi.org/10.1038/s41467-018-07309-4
Autor:
Grant Dewson, Mark Xiang Li
Publikováno v:
F1000Prime Reports
As mitochondria are the powerhouses of the cell, their damage during the cell suicide process of apoptosis is essentially responsible for cellular demise in most cells. A key family of proteins, the B-cell lymphoma-2 (BCL-2) family, determines the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::879c12bdb5d34a51dae0ece8187c98ac
http://europepmc.org/articles/PMC4447032
http://europepmc.org/articles/PMC4447032