Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Mark Wortinger"'
Publikováno v:
Extracellular Targeting of Cell Signaling in Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0bb138ba764c22a8f8f1950967c092d
https://doi.org/10.1002/9781119300229.ch7
https://doi.org/10.1002/9781119300229.ch7
Autor:
Ying Tang, Yong Wang, Julian Davies, Lihua Huang, Patricia Brown-Augsburger, Mark Wortinger, Jonathan Wendell Tetreault, Wei-an Zeng, Volker Wacheck, Jinqi Xia, Paul Cornwell, Chi Kin Chow, Darryl Ballard, Ling Liu, S. Betty Yan, Jason Manro, Jirong Lu, Victoria L. Peek, Peter Edward Vaillancourt, Irene Denning, Jennifer R. Stephens, Kelly M. Credille
Publikováno v:
Clinical Cancer Research. 20:6059-6070
Purpose: MET, the receptor for hepatocyte growth factor (HGF), has been implicated in driving tumor proliferation and metastasis. High MET expression is correlated with poor prognosis in multiple cancers. Activation of MET can be induced either by HG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa11a2aca8597fa77410f90fb34f2ff
https://doi.org/10.1158/1078-0432.ccr-14-0543
https://doi.org/10.1158/1078-0432.ccr-14-0543
Autor:
Christophe C. Marchal, Irene Denning, Peter Edward Vaillancourt, Timothy R. Holzer, Jessica A. Roseberry Baker, Aaron M Gruver, Mark Wortinger, Jirong Lu, Julian Davies, Jeffrey C. Hanson, Sameera R. Wijayawardana, Ling Liu, Megan E Lacy, Andrew E. Schade, Hadrian P. Szpurka, Sau-Chi B. Yan, Joel D. Cook, Erin M Felke, Wei Zeng, Chi-Kin Chow, Emily Rhoads, Kelly M. Credille, Gregory Beuerlein
Publikováno v:
Histopathology. 65(6)
Development of novel targeted therapies directed against hepatocyte growth factor (HGF) or its receptor (MET) necessitates the availability of quality diagnostics to facilitate their safe and effective use. Limitations of some commercially available
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49e23889656e2ea7274884c9a15c640
https://pubmed.ncbi.nlm.nih.gov/25039923
https://pubmed.ncbi.nlm.nih.gov/25039923
Autor:
Jonathan Wendell Tetreault, Darryl Ballard, Ling Liu, Peter Edward Vaillancourt, Sau-Chi B. Yan, Wei Zeng, Mark Wortinger, Jinqi Xia, Jirong Lu, Ying Tang, Kelly M. Credille, Jennifer R. Stephens, Trish Brown-Augsburger, Chi-Kin Chow, Victoria L. Peek
Publikováno v:
Cancer Research. 73:5465-5465
MET is involved in many mechanisms of cancer proliferation and metastasis. Inappropriate activation of MET can be induced by HGF-independent mechanisms such as gene amplification, specific genetic mutations, and transcriptional up-regulation, or by H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b668b52ed319eba577a5550dae3be0e
https://doi.org/10.1158/1538-7445.am2013-5465
https://doi.org/10.1158/1538-7445.am2013-5465
Autor:
Chi-Kin Chow, Lu Jirong, Victoria L. Peek, Mark Wortinger, Wei Zeng, Peter Edward Vaillancourt, Lei Yan, Ling Liu, Jason Manro, Farhana F. Merzoug, Jinqi Xia, Jonathan Wendell Tetreault, Jennifer R. Stephens, S. Betty Yan
Publikováno v:
Cancer Research. 72:2738-2738
cMet is a member of the receptor tyrosine kinase family and is the receptor for hepatocyte growth factor (HGF). cMet has been implicated in the initiation and progression of cancer due to the range of activities that cMet stimulates including prolife
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c66f5c7c5ec9c3b7244c9c0dbef4933
https://doi.org/10.1158/1538-7445.am2012-2738
https://doi.org/10.1158/1538-7445.am2012-2738
Autor:
Lei Yan, Mark Wortinger, Chi-Kin Chow, Betty Sau-Chi Indianapolis Yan, Ling Liu, Jason Manro, Victoria L. Peek, Peter Edward Vaillancourt, Spring Weir, Jennifer R. Stephens, Jinqi Xia, Jonathan Wendell Tetreault, Ying Tang, Jirong Lu, Wei Zeng
Publikováno v:
Cancer Research. 72:2734-2734
c-Met is a member of the receptor tyrosine kinase family and is the receptor for hepatocyte growth factor (HGF). c-Met is involved in many mechanisms of cancer proliferation and metastasis. Inappropriate activation of c-Met can be induced by ligand-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffdb5505a4d3ae3c4467349098f1f960
https://doi.org/10.1158/1538-7445.am2012-2734
https://doi.org/10.1158/1538-7445.am2012-2734
Autor:
Chi-Kin Chow, Jirong Lu, Sudhakar Chintharlapalli, Ling Liu, Wei Zeng, Irene Denning, Julian Davies, Wei Jennifer Yang, Lei Yan, Spring Weir, Peter Edward Vaillancourt, Mcclure Don B, Victoria L. Peek, Mark Wortinger
Publikováno v:
Cancer Research. 70:2583-2583
The receptor tyrosine kinase c-Met and its ligand HGF elicit multiple cellular activities including cell proliferation, motility, invasion, tubulogenesis, angiogenesis and anti-apoptosis. Dysregulation of this pathway has emerged as a crucial feature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b560032d317a44a8af86133aa370be6e
https://doi.org/10.1158/1538-7445.am10-2583
https://doi.org/10.1158/1538-7445.am10-2583
Autor:
Peter Edward Vaillancourt, Irene Denning, Wei Zeng, Jason B. Cunningham, Chi-Kin Chow, Kun Yu, Julian Davies, Jinqi Xia, Mark Wortinger, Jirong Lu, Ling Liu, Farhana Mohammed Feroze, Jonathan Wendell Tetreault
Publikováno v:
Cancer Research. 70:2430-2430
Gastric cancer is common in Asia, and advanced disease is typically incurable. Development of effective treatments for gastric cancer is thus a high priority to address this highly unmet clinical need. c-Met gene amplification resulting in c-Met over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fd64e0023b3fdef6294b36e67ecd298
https://doi.org/10.1158/1538-7445.am10-2430
https://doi.org/10.1158/1538-7445.am10-2430