Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Mark Winey"'
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0301084 (2024)
There is an ongoing need for antifungal agents to treat humans. Identification of new antifungal agents can be based on screening compounds using whole cell assays. Screening compounds that target a particular molecule is possible in budding yeast wh
Externí odkaz:
https://doaj.org/article/0684ce8221fd47aabf99ab306cf54a18
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Ciliates are a powerful model organism for the study of basal bodies and motile cilia. These single-celled protists contain hundreds of cilia organized in an array making them an ideal system for both light and electron microscopy studies. Isolation
Externí odkaz:
https://doaj.org/article/a9e8c83a2851419a896582af451adf1b
Publikováno v:
mSphere, Vol 1, Iss 6 (2016)
ABSTRACT Basal bodies are essential microtubule-based structures that template, anchor, and orient cilia at the cell surface. Cilia act primarily in the generation of directional fluid flow and sensory reception, both of which are utilized for a broa
Externí odkaz:
https://doaj.org/article/8bc5984034164c4f82ea927b3a321722
Autor:
Shannon Burns, Jennifer S Avena, Jay R Unruh, Zulin Yu, Sarah E Smith, Brian D Slaughter, Mark Winey, Sue L Jaspersen
Publikováno v:
eLife, Vol 4 (2015)
Duplication of the yeast centrosome (called the spindle pole body, SPB) is thought to occur through a series of discrete steps that culminate in insertion of the new SPB into the nuclear envelope (NE). To better understand this process, we developed
Externí odkaz:
https://doaj.org/article/8d1c0ba962874327a7dd1545b85446f1
Autor:
Jennifer S Avena, Shannon Burns, Zulin Yu, Christopher C Ebmeier, William M Old, Sue L Jaspersen, Mark Winey
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004666 (2014)
Duplication of centrosomes once per cell cycle is essential for bipolar spindle formation and genome maintenance and is controlled in part by cyclin-dependent kinases (Cdks). Our study identifies Sfi1, a conserved component of centrosomes, as the fir
Externí odkaz:
https://doaj.org/article/465ba8b744de49d0ac008a624402374a
Publikováno v:
PLoS Genetics, Vol 1, Iss 5, p e52 (2005)
Ciliates, although single-celled organisms, contain numerous subcellular structures and pathways usually associated with metazoans. How this cell biological complexity relates to the evolution of molecular elements is unclear, because features in the
Externí odkaz:
https://doaj.org/article/1f0b07e9ca7f4027a6fd2515fb0b534f
Publikováno v:
Annual Review of Cell and Developmental Biology. 38:75-102
Ciliates are a diverse group of unicellular eukaryotes that vary widely in size, shape, body plan, and ecological niche. Here, we review recent research advances achieved with ciliate models. Studies on patterning and regeneration have been revived i
Autor:
Westley Heydeck, Daniela Nicastro, Amy S. Fabritius, Brian A. Bayless, Christopher C. Ebmeier, Chidambaram Nachiappan, Justen B. Whittall, Tess Gunnels, Daniel Stoddard, David A. Agard, William M. Old, Sam Li, Lauren Anderson, Mark Winey
Publikováno v:
Molecular biology of the cell, vol 32, iss 21
The core structure of motile cilia and flagella, the axoneme, is built from a stable population of doublet microtubules. This unique stability is brought about, at least in part, by a network of microtubule inner proteins (MIPs) that are bound to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e13b1603954313603a5c841f3313da
https://escholarship.org/uc/item/681594gj
https://escholarship.org/uc/item/681594gj
Publikováno v:
Life Science Alliance
By using electron cryo-tomography and subtomogram average, this study reveals the assembly of T. thermophila axonemal MT doublet in wild type and mutant, showing its structure conservation and diversity compared to other organisms.
Doublet micro
Doublet micro
Autor:
Amy S, Fabritius, Brian A, Bayless, Sam, Li, Daniel, Stoddard, Westley, Heydeck, Christopher C, Ebmeier, Lauren, Anderson, Tess, Gunnels, Chidambaram, Nachiappan, Justen B, Whittall, William, Old, David A, Agard, Daniela, Nicastro, Mark, Winey
Publikováno v:
Molecular Biology of the Cell
The core structure of motile cilia and flagella, the axoneme, is built from a stable population of doublet microtubules. This unique stability is brought about, at least in part, by a network of microtubule inner proteins (MIPs) that are bound to the