Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Mark Windheim"'
Autor:
Claudia Pokoyski, Wiebke Baars, Mark Windheim, Thomas F. Reubold, Jasmin Zischke, Antje Brinkmann, Penelope C. Kay-Fedorov, Reinhard Schwinzer
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Transgenic expression of protective molecules in porcine cells and tissues is a promising approach to prevent xenograft rejection. Viruses have developed various strategies to escape the host’s immune system. We generated porcine B cells (
Externí odkaz:
https://doaj.org/article/12793a81b1ea49b0b6bc28041c5cf640
Autor:
Chanchal Chauhan, Andreas Kraemer, Stefan Knapp, Mark Windheim, Alexey Kotlyarov, Manoj B. Menon, Matthias Gaestel
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-10 (2023)
Abstract Receptor-interacting protein kinases (RIPK)-1 and -3 play crucial roles in cell fate decisions and are regulated by multiple checkpoint controls. Previous studies have identified IKK1/2- and p38/MK2-dependent checkpoints that phosphorylate R
Externí odkaz:
https://doaj.org/article/214dfff180f143c98a84560bdae9641d
Publikováno v:
Journal of Virology. 97
The battle between viruses and their hosts is an ongoing arms race. Whereas the host tries to detect and eliminate the virus, the latter counteracts such antiviral measures to replicate and spread.
Autor:
Mark Windheim
Publikováno v:
Cellular Signalling. 28:1520-1529
Interleukin-1 (IL-1) binding to its receptor triggers signaling events at the plasma membrane that are essential but not sufficient for the induction of the IL-1-dependent gene expression. In addition, the ligand-induced endocytosis of the IL-1 recep
Autor:
Stefan Höning, Christina Seed, Keith N. Leppard, Sreenivasan Ponnambalam, Mark Windheim, Larissa Butler, Hans-Gerhard Burgert
Publikováno v:
Journal of Biological Chemistry. 291:6796-6812
The E3 transcription unit of human species C adenoviruses (Ads) encodes immunomodulatory proteins that mediate direct protection of infected cells. Recently, we described a novel immunomodulatory function for E3/49K, an E3 protein uniquely expressed
Autor:
Philip Cohen, Padraic G. Fallon, Sylvia Amu, J. Simon C. Arthur, Sambit K. Nanda, Steven C. Ley, Mark Windheim, Janet C. Patterson-Kane, Gabriella Aviello, Tsunehisa Nagamori
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 201(11)
The A20-binding inhibitor of NF-κB 2 (ABIN2) interacts with Met1-linked ubiquitin chains and is an integral component of the tumor progression locus 2 (Tpl2) kinase complex. We generated a knock-in mouse expressing the ubiquitin-binding–defective
Publikováno v:
Cellular Signalling. 25:214-228
Interleukin-1 (IL-1) induces the internalization of its cognate receptor from the plasma membrane. However, it has remained elusive as to how this mechanism affects the IL-1-induced signal transduction. In this study, we used small-molecule inhibitor
Publikováno v:
Molecular and Cellular Biology. 28:1783-1791
Interleukin 1 (IL-1) has been reported to stimulate the polyubiquitination and disappearance of IL-1 receptor-associated kinase 1 (IRAK1) within minutes. It has been thought that the polyubiquitin chains attached to IRAK1 are linked via Lys48 of ubiq
Autor:
Emma Carrick, Nick Morrice, Hilary Smith, Mark Peggie, Mark Windheim, Philip Cohen, Alban Ordureau
Publikováno v:
Biochemical Journal. 409:43-52
The protein kinases IRAK [IL-1 (interleukin 1) receptor-associated kinase] 1 and 4 play key roles in a signalling pathway by which bacterial infection or IL-1 trigger the production of inflammatory mediators. In the present study, we demonstrate that
Autor:
J Southcombe, Elisabeth Kremmer, Christine S. Falk, Harald Renz, Hans-Gerhard Burgert, Janine Mihm, Martina Sester, Doris Urlaub, Mark Windheim, Lucy Chaplin, Kevin M. Dennehy, Carsten Watzl, Maren Claus, Myles Braithwaite
Publikováno v:
Proc. Natl. Acad. Sci. U.S.A. 110, E4884-E4893 (2013)
The E3 transcription unit of human adenoviruses (Ads) encodes immunomodulatory proteins. Interestingly, the size and composition of the E3 region differs considerably among Ad species, suggesting that distinct sets of immunomodulatory E3 proteins may