Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Mark Wills"'
Autor:
Timo W. M. De Groof, Elizabeth G. Elder, Eleanor Y. Lim, Raimond Heukers, Nick D. Bergkamp, Ian J. Groves, Mark Wills, John H. Sinclair, Martine J. Smit
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Human cytomegalovirus (HCMV) can evade immune responses in latent reservoirs, which is a specific problem during transplantation. Here the authors develop a bivalent nanobody that is specific for US28, a viral receptor required by latent HCMV, and sh
Externí odkaz:
https://doaj.org/article/f6e7b525a9434aba8b55e7c5d8bcbd9e
Autor:
Emma Poole, Maria Cristina Carlan da Silva, Chris Huang, Marianne Perera, Sarah Jackson, Ian J. Groves, Mark Wills, Amer Rana, John Sinclair
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
Understanding the mechanisms which regulate HCMV latency could allow therapeutic targeting of the latent virus reservoir from where virus reactivation can cause severe disease. We show that the BMPR2/TGFbeta receptor/YY1 signaling axis is crucial to
Externí odkaz:
https://doaj.org/article/c5a89e14f27243eba150c45f5244720d
Autor:
Yusuf Aslam, James Williamson, Veronika Romashova, Elizabeth Elder, Benjamin Krishna, Mark Wills, Paul Lehner, John Sinclair, Emma Poole
Publikováno v:
iScience, Vol 20, Iss , Pp 60-72 (2019)
Summary: Human cytomegalovirus establishes a lifelong, latent infection in the human host and can cause significant morbidity and mortality, particularly, in immunocompromised individuals. One established site of HCMV latency and reactivation is in c
Externí odkaz:
https://doaj.org/article/2ab4db567d2d48dc9a710eefe2598758
Autor:
Elizabeth G. Elder, Benjamin A. Krishna, James Williamson, Eleanor Y. Lim, Emma Poole, George X. Sedikides, Mark Wills, Christine M. O’Connor, Paul J. Lehner, John Sinclair
Publikováno v:
mBio, Vol 10, Iss 6 (2019)
ABSTRACT Human cytomegalovirus (HCMV) latency is an active process which remodels the latently infected cell to optimize latent carriage and reactivation. This is achieved, in part, through the expression of viral genes, including the G-protein-coupl
Externí odkaz:
https://doaj.org/article/380acf94ae2e407ba81bc144361f8da4
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-12 (2018)
Abstract Background Human cytomegalovirus (HCMV) has a double-stranded DNA genome of approximately 235 Kbp that is structurally complex including extended GC-rich repeated regions. Genomic recombination events are frequent in HCMV cultures but have a
Externí odkaz:
https://doaj.org/article/d1fc99eb0e6042aab37e329a3b16ae18
Autor:
Andreas Neerincx, Aure Aflalo, Ida Hafstrand, Alice Abreu Torres, Alison McDowall, Arwen Altenburg, Reem Satti, F Ilca, Klaus Okkenhaug, Mark Wills, Louise Boyle
Low tumour immunogenicity is a major hurdle to overcome in the treatment of cancers with immunotherapies. Here, we reveal a novel therapeutic approach to increase tumour immunogenicity. By delivering the major histocompatibility complex class I (MHC-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b356b06cfae70b3a2693374b1b5245a
https://doi.org/10.21203/rs.3.rs-2357899/v1
https://doi.org/10.21203/rs.3.rs-2357899/v1
Autor:
Benjamin Krishna, Eleanor Lim, Lenette Mactavous, Sarah Jackson, NIHR BioResource Team NIHR BioResource Team, Paul Lyons, Rainer Doffinger, John Bradley, Kenneth Smith, John Sinclair, Nicholas Matheson, Paul Lehner, Nyaradzai Sithole, Mark Wills
After acute infection with Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), a significant proportion (0.2 – 30%) of patients experience persistent symptoms beyond 12 weeks, termed Long COVID. Understanding the mechanisms which cause th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9102a324d481581c3c9c5a171167668f
https://doi.org/10.21203/rs.3.rs-2034285/v2
https://doi.org/10.21203/rs.3.rs-2034285/v2
Autor:
Georgina Hopkins, Nancy Gomez, Davis Tucis, Laura Barlett, William Browne, Silvia Granata, Hannah Jackson, Graham Steers, Tyler Harvey-Cowlishaw, Victoria James, Adam Watkins, Mark Wills, Andrew Godkin, Fiona Pearce, Peter Lanyon, David Onion, Paddy Tighe, Lucy Fairclough
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______4094::7588b9c54d51a20d1847bbc6df63e3d6
http://hdl.handle.net/11585/886947
http://hdl.handle.net/11585/886947
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2244
The extensive tropism of human cytomegalovirus (HCMV) results in the productive infection of multiple cell types within the human host. However, infection of other cell types, such as undifferentiated cells of the myeloid lineage, give rise to nonper
Autor:
Hongbing Yang, Anuska Llano, Samandhy Cedeño, Annette von Delft, Angelica Corcuera, Geraldine M. Gillespie, Andrew Knox, Darren B. Leneghan, John Frater, Wolfgang Stöhr, Sarah Fidler, Beatriz Mothe, Johnson Mak, Christian Brander, Nicola Ternette, Lucy Dorrell, Eric Sandström, Janet Darbyshire, Frank Post, Christopher Conlon, Jane Anderson, Mala Maini, Timothy Peto, Peter Sasieni, Veronica Miller, Ian Weller, Abdel Babiker, Sarah Pett, Matthew Pace, Natalia Olejniczak, Helen Brown, Nicola Robinson, Jakub Kopycinski, Tomáš Hanke, Alison Crook, Steven Kaye, Myra McClure, Otto Erlwein, Andrew Lovell, Maryam Khan, Michelle Gabrielle, Rachel Bennett, Aminata Sy, Adam Gregory, Fleur Hudson, Charlotte Russell, Gemma Wood, Hanna Box, Cherry Kingsley, Katie Topping, Andrew Lever, Mark Wills, Axel Fun, Mikaila Bandara, Damian Kelly, Simon Collins, Alex Markham, Mary Rauchenberger, Yinka Sowunmi, Shaadi Shidfar, Dominic Hague, Mark Nelson, Maddalena Cerrone, Nadia Castrillo Martinez, Tristan Barber, Alexandra Schoolmeesters, Christine Weaver, Orla Thunder, Jane Rowlands, Christopher Higgs, Serge Fedele, Margherita Bracchi, Lervina Thomas, Peter Bourke, Nneka Nwokolo, Gaynor Lawrenson, Marzia Fiorino, Hinal Lukha, Sabine Kinloch-de Loes, Margaret Johnson, Alice Nightingale, Nnenna Ngwu, Patrick Byrne, Zoe Cuthbertson, Martin Jones, Tina Fernandez, Amanda Clarke, Martin Fisher, Rebecca Gleig, Vittorio Trevitt, Colin Fitzpatrick, Tanya Adams, Fiounnuala Finnerty, John Thornhill, Heather Lewis, Kristin Kuldanek, Julie Fox, Julianne Lwanga, Hiromi Uzu, Ming Lee, Simon Merle, Patrick O’Rourke, Isabel Jendrulek, Taras Zarko Flynn, Mark Taylor, Juan Manuel Tiraboschi, Tammy Murray
Publikováno v:
Cell Reports
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Persistence of HIV through integration into host DNA in CD4(+) T cells presents a major barrier to virus eradication. Viral integration may be curtailed when CD8(+) T cells are triggered to kill infected CD4(+) T cells through recognition of histocom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6f7b05b028eaac835e405a6ac4e7c84
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2035
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2035