Výsledky vyhledávání - "Mark W.C. Hatton"

HUMAN TRANSFERRIN, ASIALOTRANSFERRIN AND THE INTERMEDIATE FORMS

Autor: Maria T. Debanne, Mark W.C. Hatton, Erwin Regoeczi, K.-L. Wong

Publikováno v: International Journal of Peptide and Protein Research. 12:27-37

Six protein fractions were isolated from mixtures of neuraminidase-treated and untreated samples of human transferrin type C (TfC) in the 2Fe-form by chromatography on DEAE-cellulose. The first 2Fe-TfC peak (designated TfC-1–6) to desorb from the c

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https://doi.org/10.1111/j.1399-3011.1978.tb02864.x

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Uptake of Fe III influences the topographical arrangement of N-glycan(s) in human transferrin

Autor: Mark W.C. Hatton, Leslie R. Berry

Publikováno v: International Journal of Peptide and Protein Research. 25:166-170

The relative prominence of sialyl and α-mannosyl residues of apo- and metal-bound transferrin were compared. Although the presence or absence of FeIII did not significantly affect the rate of desialylation of the glycoprotein, equilibrium dialysis w

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https://doi.org/10.1111/j.1399-3011.1985.tb02160.x

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Human ovarian cancer ascites fluid contains a mixture of incompletely degraded soluble products of fibrin that collectively possess an antiangiogenic property

Autor: Gurmit Singh, M. Richardson, Narveen Jandu, H. Hirte, Mark W.C. Hatton

Publikováno v: International Journal of Gynecological Cancer. 16:1536-1544

Ovarian cancer ascites fluid (OCAF) displayed an antiangiogenic property in a chick chorioallantoic membrane (CAM) assay. This property was attributed in part to angiostatin although angiostatin-free OCAF retained a net antiangiogenic property. Recen

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https://doi.org/10.1111/j.1525-1438.2006.00624.x

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Relationships among tumor burden, tumor size, and the changing concentrations of fibrin degradation products and fibrinolytic factors in the pleural effusions of rabbits with VX2 lung tumors

Autor: Mary Richardson, Bonnie Ross, Gurmit Singh, Bryan J. Clarke, Suzanne M.R. Southward, Mark W.C. Hatton

Publikováno v: Journal of Laboratory and Clinical Medicine. 147:27-35

The VX2 tumor is derived from a papilloma virus-induced rabbit epithelial cell line. If VX2 tumor cells (trapped in a plasma clot) are introduced intravenously into NZW rabbits, the cells lodge in the lung capillary bed and produce tumors. Independen

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https://doi.org/10.1016/j.lab.2005.08.014

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Fibrinogen catabolism within the procoagulant VX-2 tumor of rabbit lung in vivo: effluxing fibrin(ogen) fragments contain antiangiogenic activity

Autor: Morris A. Blajchman, Bonnie Ross, Kimberly Legault, Mark W.C. Hatton, Gurmit Singh, Suzanne M.R. Southward, Laszlo Bajzar, Bryan J. Clarke, Mary Richardson

Publikováno v: Journal of Laboratory and Clinical Medicine. 143:241-254

Many types of solid tumors are known to be procoagulant environments. This is partly because a hyperpermeable vascular system within the tumor allows plasma hemostatic factors to accumulate in relatively high concentrations in the stroma, and many so

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https://doi.org/10.1016/j.lab.2004.01.006

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Malignant Ascites Fluid (MAF), Including Ovarian-Cancer-Associated MAF, Contains Angiostatin and Other Factor(s) Which Inhibit Angiogenesis

Autor: Gurmit Singh, J. Gunawan, M. Richardson, Hal W. Hirte, Eric Seidlitz, Mark W.C. Hatton

Publikováno v: Gynecologic Oncology. 86:279-287

Objective. The aim was to determine whether human malignant ascites fluid (MAF) associated with abdominal cancer, including ovarian cancer, contained factors which inhibit angiogenesis as well as others which stimulate this process. Methods. MAF was

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https://doi.org/10.1006/gyno.2002.6760

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Angiostatin II is the predominant glycoform in pleural effusates of rabbit VX-2 lung tumors

Autor: Kimberly Legault, Lindsay Marien, Darren Korbie, Bryan J. Clarke, Bonnie Ross, Morris A. Blajchman, Mark W.C. Hatton, Gurmit Singh, Mary Richardson, Suzanne M.R. Southward

Publikováno v: Journal of Laboratory and Clinical Medicine. 139:316-323

Angiostatin (AST), a polypeptide with potent antiangiogenic properties, is released proteolytically from plasminogen in vivo. Plasminogen exists naturally in plasma as two glycoforms (PLGs), I and II. Recently it was shown with the use of a chick-emb

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https://doi.org/10.1067/mlc.2002.123267

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Metabolism of rabbit plasma-derived factor VII in relation to prothrombin in rabbits

Autor: Suzanne M.R. Southward, Sampath Sridhara, Bryan J. Clarke, Bonnie Ross, Morris A. Blajchman, Mark W.C. Hatton, Myron Kulzcycky

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 281:E507-E515

In the human circulation, factor VII is present in relatively low plasma concentration (0.01 μM) and has been reported to have a short half-life ( t½; 6 h). In contrast, prothrombin is present in a relatively high plasma concentration (2 μM) and h

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https://doi.org/10.1152/ajpendo.2001.281.3.e507

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