Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Mark W. Zimmerman"'
Autor:
Nina Weichert-Leahey, Hui Shi, Ting Tao, Derek A. Oldridge, Adam D. Durbin, Brian J. Abraham, Mark W. Zimmerman, Shizhen Zhu, Andrew C. Wood, Deepak Reyon, J. Keith Joung, Richard A. Young, Sharon J. Diskin, John M. Maris, A. Thomas Look
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 10 (2023)
Childhood neuroblastomas exhibit plasticity between an undifferentiated neural crest–like mesenchymal cell state and a more differentiated sympathetic adrenergic cell state. These cell states are governed by autoregulatory transcriptional loops cal
Externí odkaz:
https://doaj.org/article/26b30da61a8a4fd2905ae5306aa93199
Autor:
Huan-Chang Liang, Mariantonia Costanza, Nicole Prutsch, Mark W. Zimmerman, Elisabeth Gurnhofer, Ivonne A. Montes-Mojarro, Brian J. Abraham, Nina Prokoph, Stefan Stoiber, Simone Tangermann, Cosimo Lobello, Jan Oppelt, Ioannis Anagnostopoulos, Thomas Hielscher, Shahid Pervez, Wolfram Klapper, Francesca Zammarchi, Daniel-Adriano Silva, K. Christopher Garcia, David Baker, Martin Janz, Nikolai Schleussner, Falko Fend, Šárka Pospíšilová, Andrea Janiková, Jacqueline Wallwitz, Dagmar Stoiber, Ingrid Simonitsch-Klupp, Lorenzo Cerroni, Stefano Pileri, Laurence de Leval, David Sibon, Virginie Fataccioli, Philippe Gaulard, Chalid Assaf, Fabian Knörr, Christine Damm-Welk, Wilhelm Woessmann, Suzanne D. Turner, A. Thomas Look, Stephan Mathas, Lukas Kenner, Olaf Merkel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Anaplastic large cell lymphoma (ALCL) is an aggressive T-cell lymphoma often with poor prognosis. To identify genes defining ALCL cell state and dependencies, the authors here characterize ALCL-specific super-enhancers and describe the BATF3/IL-2R−
Externí odkaz:
https://doaj.org/article/6005c21ca6e84b989b1eb0469795a79b
ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry
Autor:
Lu Wang, Tze King Tan, Adam D. Durbin, Mark W. Zimmerman, Brian J. Abraham, Shi Hao Tan, Phuong Cao Thi Ngoc, Nina Weichert-Leahey, Koshi Akahane, Lee N. Lawton, Jo Lynne Rokita, John M. Maris, Richard A. Young, A. Thomas Look, Takaomi Sanda
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Polymorphisms in LMO1 are associated with increased susceptibility to develop neuroblastoma. Here, the authors show that LMO1 directly induces the transcription factor ASCL1, which regulates the differentiation of neurons, demonstrating that ASCL1 is
Externí odkaz:
https://doaj.org/article/e6eb4888c5884e66bc019c078ad386b1
Autor:
Felix Oppel, Dong H. Ki, Mark W. Zimmerman, Kenneth N. Ross, Ting Tao, Hui Shi, Shuning He, Jon C. Aster, A. Thomas Look
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 8 (2020)
Polycomb repressive complex 2 (PRC2) is an epigenetic regulator of gene expression that possesses histone methyltransferase activity. PRC2 trimethylates lysine 27 of histone H3 proteins (H3K27me3) as a chromatin modification associated with repressed
Externí odkaz:
https://doaj.org/article/9652420fb6814c8ab9af147d0275ee95
Autor:
Jolien De Wyn, Mark W. Zimmerman, Nina Weichert-Leahey, Carolina Nunes, Belamy B. Cheung, Brian J. Abraham, Anneleen Beckers, Pieter-Jan Volders, Bieke Decaesteker, Daniel R. Carter, Alfred Thomas Look, Katleen De Preter, Wouter Van Loocke, Glenn M. Marshall, Adam D. Durbin, Frank Speleman, Kaat Durinck
Publikováno v:
Cancers, Vol 13, Iss 19, p 4783 (2021)
Roughly half of all high-risk neuroblastoma patients present with MYCN amplification. The molecular consequences of MYCN overexpression in this aggressive pediatric tumor have been studied for decades, but thus far, our understanding of the early ini
Externí odkaz:
https://doaj.org/article/915b0ee3e5534ef8abaa8c141e83471f
Autor:
Julie M. Cramer, Mark W. Zimmerman, Tim Thompson, Gregg E. Homanics, John S. Lazo, Eric Lagasse
Publikováno v:
Stem Cell Research, Vol 13, Iss 1, Pp 164-171 (2014)
The PTP4A3 gene is highly expressed in human colon cancer and often associates with enhanced metastatic potential. Genetic disruption of the mouse Ptp4a3 gene reduces the frequency of colon tumor formation in mice treated in a colitis-associated canc
Externí odkaz:
https://doaj.org/article/6706bdf6017147a0bb784ccec4764239
Autor:
Chang‐Bin Jing, Nicole Prutsch, Shuning He, Mark W. Zimmerman, Yosef Landesman, A. Thomas Look
Publikováno v:
British Journal of Haematology. 201:489-501
Autor:
Jun Qi, A. Thomas Look, Kimberly Stegmaier, Brian J. Abraham, Martha L. Bulyk, Ernst Schönbrunn, John Easton, Olaf Wiest, Taylor R. Quinn, Melissa J. Bikowitz, Antonio R. Perez-Atayde, Amanda L. Robichaud, Amy Saur Conway, Ken Morita, Logan H. Sigua, Paul M.C. Park, Lily Maxham, Maya Mundada, Ying Shao, Anand G. Patel, Stephanie Nance, Noha A.M. Shendy, Luca Mariani, Neekesh V. Dharia, Deyao Li, Mark W. Zimmerman, Virangika K. Wimalasena, Tingjian Wang, Adam D. Durbin
Supplementary Data from EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::700913e64764f6e6c15c2df8eb0c5d30
https://doi.org/10.1158/2159-8290.22541228
https://doi.org/10.1158/2159-8290.22541228
Autor:
Jun Qi, A. Thomas Look, Kimberly Stegmaier, Brian J. Abraham, Martha L. Bulyk, Ernst Schönbrunn, John Easton, Olaf Wiest, Taylor R. Quinn, Melissa J. Bikowitz, Antonio R. Perez-Atayde, Amanda L. Robichaud, Amy Saur Conway, Ken Morita, Logan H. Sigua, Paul M.C. Park, Lily Maxham, Maya Mundada, Ying Shao, Anand G. Patel, Stephanie Nance, Noha A.M. Shendy, Luca Mariani, Neekesh V. Dharia, Deyao Li, Mark W. Zimmerman, Virangika K. Wimalasena, Tingjian Wang, Adam D. Durbin
Gene expression is regulated by promoters and enhancers marked by histone H3 lysine 27 acetylation (H3K27ac), which is established by the paralogous histone acetyltransferases (HAT) EP300 and CBP. These enzymes display overlapping regulatory roles in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61071f79f8085d7c8ad075581b3011bc
https://doi.org/10.1158/2159-8290.c.6549578.v1
https://doi.org/10.1158/2159-8290.c.6549578.v1
Autor:
A. Thomas Look, Holger Sudhoff, Jon C. Aster, Susan N. Chi, Peter Goon, Viyof Ful Flavian, Matthias Schürmann, Mark W. Zimmerman, Sarah Gendreizig, Senyao Shao, Felix Oppel
Supplementary Data from p53 Pathway Inactivation Drives SMARCB1-deficient p53-wildtype Epithelioid Sarcoma Onset Indicating Therapeutic Vulnerability Through MDM2 Inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbebe9035bfdea25a65ea647b50bc6c9
https://doi.org/10.1158/1535-7163.22523211.v1
https://doi.org/10.1158/1535-7163.22523211.v1