Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Mark W. Thompson"'
Publikováno v:
Northwest Science. 91:367-382
Beargrass (Xerophyllum tenax [Pursh] Nutt.) is an herbaceous, evergreen perennial found in higher elevations of the northern Rocky, Sierra Nevada, Klamath, Siskiyou, Cascade and Olympic Mountains and in coastal areas from Washington to northern Calif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a224f00630432ac21401743bc6bc9ea3
https://doi.org/10.3955/046.091.0406
https://doi.org/10.3955/046.091.0406
Autor:
Vincenzo Calandra, Steven I. Dworetzky, Yong-Jin Wu, Ronald J. Knox, William Fitzpatrick, Huan He, JoAnne E Natale, David G. Harden, Li-Qiang Sun, Carl D. Davis, David Weaver, Frederic Machet, Joseph Polino, John E. Starrett, Karen Heman, Ping Chen, Valentin K. Gribkoff, Christopher G. Boissard, Clotilde Bourin, Charles M. Conway, Jie Chen, Mark W. Thompson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:6188-6191
Acrylamide (S)-6, a potent and efficacious KCNQ2 (Kv7.2) opener, demonstrated significant activity in two models of neuropathic pain and in the formalin test, suggesting that KCNQ2 openers may be useful in the treatment of neuropathic pain including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c81071ad17f712c14b9149ad6dfe150
https://doi.org/10.1016/j.bmcl.2013.08.092
https://doi.org/10.1016/j.bmcl.2013.08.092
Autor:
Elena, Eliadou, Andrew S, Day, Mark W, Thompson-Fawcett, Richard B, Gearry, David S, Rowbotham, Russel, Walmsley, Michael, Schultz, Stephen J, Inns
Publikováno v:
The New Zealand medical journal. 128(1423)
The management of patients with ulcerative colitis who are dependent on corticosteroid for control of symptoms, or refractory to corticosteroids or standard immunosuppressive therapy, is challenging. The development of newer medical therapies has inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::60bc1278c99079cd01ed7d1aaf6931e5
https://pubmed.ncbi.nlm.nih.gov/26645757
https://pubmed.ncbi.nlm.nih.gov/26645757
Autor:
Bergstrom Carl P, Jeremy H. Toyn, Robert H. Grafstrom, Yang Michael G, Mcelhone Katharine E, Michael J. Ford, Cathy J. Kieras, Yang Cao, Dietmar A. Seiffert, Richard E. Olson, Lawrence G. Iben, Charles F. Albright, Joseph L. Cantone, Craig Polson, Maria Pierdomenico, Jason A. Corsa, Dieter M. Drexler, John E. Macor, Jere E. Meredith, Margi E. Goldstein, Lisa M. Sisk, Mark W. Thompson, Joanne J. Bronson, Arthur H. Roach, Catherine R. Burton, Tracey Fiedler, Carol M. Krause, Robert Zaczek, Yuval Blat, Donna M. Barten, Andrew M. Stern, Xu-Alan Lin
Publikováno v:
Journal of Biological Chemistry. 283:22992-23003
The amyloid-beta (Abeta) peptide, which likely plays a key role in Alzheimer disease, is derived from the amyloid-beta precursor protein (APP) through consecutive proteolytic cleavages by beta-site APP-cleaving enzyme and gamma-secretase. Unexpectedl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efba80ada17865ffd18096d0a9820ce3
https://doi.org/10.1074/jbc.m804175200
https://doi.org/10.1074/jbc.m804175200
Autor:
Alain Martel, Li-Qiang Sun, Jie Chen, Huan He, Ronald J. Knox, David G. Harden, JoAnne E Natale, Steven I. Dworetzky, Yong-Jin Wu, Alexandre L'Heureux, David Weaver, John E. Starrett, Mark W. Thompson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:363-366
Replacement of the morpholinyl moiety in (S,E)-N-[1-(3-morpholinophenyl)ethyl]-3-phenylacrylamide (1) with heteroaryl groups led to the identification of (S,E)-N-1-[3-(6-fluoropyridin-3-yl)phenyl]ethyl-3-(2-fluorophenyl)acrylamide (5) as a potent KCN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb33adb537a4bf34b46494a7e279e57f
https://doi.org/10.1016/j.bmcl.2004.10.065
https://doi.org/10.1016/j.bmcl.2004.10.065
Publikováno v:
Journal of Structural Biology. 148:338-352
We have determined a 2.1 A crystal structure for human mitochondrial ClpP (hClpP), the proteolytic component of the ATP-dependent ClpXP protease. HClpP has a structure similar to that of the bacterial enzyme, with the proteolytic active sites sequest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d153c3be6dcaffef8bc3d04cd6ade2
https://doi.org/10.1016/j.jsb.2004.07.004
https://doi.org/10.1016/j.jsb.2004.07.004
Autor:
Jean-Paul Daris, John E. Starrett, Pierre Dextraze, Rick L. Pieschl, Huan He, David G. Harden, David Weaver, Jie Chen, Yong-Jin Wu, Ronald J. Knox, Valentin K. Gribkoff, Li-Qiang Sun, Qi Gao, Mark W. Thompson, Dedong Wu, Christopher G. Boissard, Steven I. Dworetzky, William Fitzpatrick, JoAnne E Natale
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4533-4537
Bioisosteric replacement studies led to the identification of N -(1-benzo[1,3]dioxol-5-yl-ethyl)-3-(2-chloro-phenyl)-acrylamide (( S )- 3 ) as a highly potent KCNQ2 opener, and 3-(2,6-difluoro-phenyl)- N -[1-(2,3-dihydro-benzofuran-5-yl)-ethyl]-acryl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca337a8d17cff2971f2f629786972798
https://doi.org/10.1016/j.bmcl.2004.06.035
https://doi.org/10.1016/j.bmcl.2004.06.035
Autor:
Bradley A. Yoder, Mark W. Thompson, Deirdre Flynn, Roberta Williams, LoRanee Braun, Chia Wen Ko, Jeffrey R. Greenwald, Benton B. Curley
Publikováno v:
Ambulatory Pediatrics. 4:461-467
Background.—Military hospitals currently use gestational age-specific growth curves based on data collected in Denver, Colo, from 1948 to 1961. A number of population and environmental factors and medical practice changes may make these curves nonr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a642f8dfaf3fc327201c604f31e99e0
https://doi.org/10.1367/a03-022r.1
https://doi.org/10.1367/a03-022r.1
Autor:
Christopher G. Boissard, Huan He, David Weaver, Valentin K. Gribkoff, David G. Harden, Jie Chen, Qi Gao, Mark W. Thompson, Li-Qiang Sun, Dedong Wu, William Fitzpatrick, JoAnne E Natale, John E. Starrett, Yong-Jin Wu, Rick L. Pieschl, Ronald J. Knox, Steven I. Dworetzky
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:1991-1995
(S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide ((S)-2) was identified as a potent and efficacious KCNQ2 opener. This compound demonstrated significant activity in reducing neuronal hyperexcit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73ffe93db9f647df1e793f8446a06bbc
https://doi.org/10.1016/j.bmcl.2004.01.069
https://doi.org/10.1016/j.bmcl.2004.01.069
Autor:
Shing Hong Kang, Svetlana Tertyshnikova, Michael Sinz, Sanna Lehtinen-Oboma, John E. Starrett, Yong-Jin Wu, Steven I. Dworetzky, Alexandre L'Heureux, Digavalli V. Sivarao, Mark W. Thompson, Gene G. Kinney, Christopher G. Boissard, Amy Newton, David Weaver, Henry S. Wong, Ronald J. Knox, Valentin K. Gribkoff, Li-Qiang Sun, Lei Zhang, JoAnne E Natale, Corinne R. Greco, Huan He, David G. Harden
Publikováno v:
Journal of Medicinal Chemistry. 46:3197-3200
(S)-N-[1-(3-Morpholin-4-ylphenyl)ethyl]-3-phenylacrylamide (2) was synthesized as an orally bioavailable KCNQ2 potassium channel opener. In a rat model of migraine, 2 demonstrated significant oral activity in reducing the total number of cortical spr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071a82a89a8a915e31f48b6c58bd4901
https://doi.org/10.1021/jm034073f
https://doi.org/10.1021/jm034073f