Výsledky vyhledávání - "Mark W. Rolfe"

Significant Tracheal Obstruction Causing Failure to Wean in Patients Requiring Prolonged Mechanical Ventilation

Autor: Mark J. Rumbak, Mark W. Rolfe, Frank Walsh, W. McDowell Anderson, David A. Solomon

Publikováno v: Chest. 115:1092-1095

Introduction Modern low-pressure, high-volume cuffed tracheotomy tubes have been shown to decrease tracheal injury. However, injury still occurs in patients requiring prolonged mechanical ventilation and prevents weaning, delays decannulation, prolon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::50db250cc9c1acf1af1fbe04dd11a79d
https://doi.org/10.1378/chest.115.4.1092

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Increased interleukin-1 receptor antagonist in idiopathic pulmonary fibrosis. A compartmental analysis

Autor: Steven L. Kunkel, Fernando J. Martinez, Marie D. Burdick, Douglas A. Arenberg, Carol A. Wilke, Mark B. Orringer, Mark W. Rolfe, J. N. Hampton, Theodore J. Standiford, Robert M. Strieter, Joseph P. Lynch, Daniel R. Smith, Richard I. Whyte

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 151:1965-1973

Idiopathic pulmonary fibrosis (IPF) is a poorly understood interstitial disease that usually proves refractory to therapy and results in irreversible tissue scarring and pulmonary dysfunction. Previous investigations have suggested a number of possib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e0d4c80eaa41d708867a7bd30e5cc0
https://doi.org/10.1164/ajrccm.151.6.7767546

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Fosfomycin/tobramycin for inhalation in patients with cystic fibrosis with pseudomonas airway infection

Autor: A. Bruce Montgomery, Susanna A. McColley, Matthew McKevitt, Lisa Moorehead, Jonathan M. Rosen, Dana Kissner, David E. Geller, Bruce C. Trapnell, Mark W. Rolfe

Publikováno v: American journal of respiratory and critical care medicine. 185(2)

Fosfomycin/tobramycin for inhalation (FTI), a unique, broad-spectrum antibiotic combination, may have therapeutic potential for patients with cystic fibrosis (CF).To evaluate safety and efficacy of FTI (160/40 mg or 80/20 mg), administered twice dail

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a699edd9392a07e09bd10a8b501c5863
https://pubmed.ncbi.nlm.nih.gov/22095545

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Interleukin-1 Receptor Antagonist Expression in Sarcoidosis

Autor: Andrew R. Gilbert, Steven L. Kunkel, Theodore J. Standiford, Robert M. Strieter, Joseph P. Lynch, Marie D. Burdick, Mark W. Rolfe

Publikováno v: American Review of Respiratory Disease. 148:1378-1384

Sarcoidosis is a systemic granulomatous disease with a marked propensity for involvement of the pulmonary parenchyma and thoracic lymphatic system. This granulomatous process is characterized by aggregations of mononuclear cells, multinucleated giant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb406739974917bab926f22d140c73b5
https://doi.org/10.1164/ajrccm/148.5.1378

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Inflammatory and Procoagulant Mediator Interactions in an Experimental Baboon Model of Venous Thrombosis

Autor: Charles T. Esmon, Lazar J. Greenfield, Fletcher B. Taylor, Mark W. Rolfe, Amy M. Kadell, Steven L. Kunkel, Thomas W. Wakefield, Gerald D. Abrams, Marie D. Burdick, Alphonse DeLucia, Shirley K. Wrobleski, Robert M. Strieter

Publikováno v: Thrombosis and Haemostasis. 69:164-172

SummaryTheoretic and in vitro evidence suggests that thrombosis and inflammation are interrelated. The purpose of the present study was to define the relationship between inflammation and deep venous thrombosis (DVT) in an in vivo model. Initiation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb05382511e8984c5b70cf593e50bb58
https://doi.org/10.1055/s-0038-1651574

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RNA interference therapy in lung transplant patients infected with respiratory syncytial virus

Autor: Jeffrey Cehelsky, Mark W. Rolfe, John P. DeVincenzo, Sara Nochur, Gary Albert, Jens Gottlieb, Akshay Vaishnaw, Marie Budev, Atul Humar, Jared Gollob, Allan R. Glanville, Martin R. Zamora

Publikováno v: American journal of respiratory and critical care medicine. 183(4)

Lower respiratory tract infections due to respiratory syncytial virus (RSV) are associated with development of bronchiolitis obliterans syndrome in lung transplant (LTX) recipients. ALN-RSV01 is a small interfering RNA targeting RSV replication.To de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa86d2e8408ca417957f8ee97436a14
https://pubmed.ncbi.nlm.nih.gov/21325081

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Expression and regulation of human pulmonary fibroblast-derived monocyte chemotactic peptide-1

Autor: Holly L. Evanoff, S L Kunkel, Theodore J. Standiford, Robert M. Strieter, Marie D. Burdick, Mark W. Rolfe, Mark B. Orringer, Sem H. Phan

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 263:L536-L545

Monocyte recruitment is essential for maintenance of normal pulmonary macrophage populations. In addition, acute and chronic inflammatory pulmonary diseases are associated with sequestration of mononuclear phagocytes in the lung. Although alveolar ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6e7a3c67feb17899e5723cf269db02
https://doi.org/10.1152/ajplung.1992.263.5.l536

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Suppression of Human Alveolar Macrophage-derived Cytokines by Amiloride

Autor: Edward J. Cragoe, Brad Rowens, Mark W. Rolfe, Steven L. Kunkel, Theodore J. Standiford, Robert M. Strieter

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 6:576-582

Various human alveolar macrophage (AM)-derived cytokines in the lungs have been shown to be present under conditions of normal homeostasis as well as during the pathogenesis of inflammation. Although extensive investigation has demonstrated the induc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5fff465448bfd2257b4a3d79538fda
https://doi.org/10.1165/ajrcmb/6.6.576

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Neutrophilic Alveolitis in Idiopathic Pulmonary Fibrosis: The Role of Interleukin-8

Autor: Mark W. Rolfe, Theodore J. Standiford, Robert M. Strieter, Joseph P. Lynch, Steven L. Kunkel

Publikováno v: American Review of Respiratory Disease. 145:1433-1439

Idiopathic pulmonary fibrosis is an immunologically mediated pulmonary disorder in which activated alveolar macrophages (AM) and neutrophils play cardinal roles in the pathogenesis of the inflammatory lung lesion. The factors responsible for the indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0bedf2d22716fbcc020bbbf278817b0
https://doi.org/10.1164/ajrccm/145.6.1433

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