Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mark W. Powley"'
Autor:
Joel P. Bercu, Ailis Maisey, Alejandra Trejo-Martin, Melisa Masuda-Herrera, John Nicolette, Erika Udovic, Elizabeth A. Martin, Eric Dowdy, James Harvey, Angela White, Susanne Glowienke, Michelle O. Kenyon, Jessica C. Graham, Mark W. Powley, Patricia Parris
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 126
The presence of impurities in drugs is unavoidable. As impurities offer no direct benefit to the patient, it is critical that impurities do not compromise patient safety. Current guidelines on the derivation of acceptable impurity levels leave aspect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b37d8297b148acddb2ccc507898137f
https://pubmed.ncbi.nlm.nih.gov/34363920
https://pubmed.ncbi.nlm.nih.gov/34363920
Autor:
Mark W. Powley
Drug development is a lengthy, multi-step process designed to characterize the safety and efficacy of drug candidates before being approved for marketing. Progression through the range of clinical trials and ultimately to product approval depends on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::322335c523ad984adacc99ec38dc5dc7
https://doi.org/10.1039/9781782621836-00413
https://doi.org/10.1039/9781782621836-00413
Publikováno v:
Carcinogenesis. 26:1573-1580
1,3-Butadiene (BD) is a confirmed rodent carcinogen and a suspect human carcinogen that forms mutagenic epoxide metabolites during biotransformation. Species differences in the roles of individual DNA reactive intermediates in BD mutagenicity and car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac3996c18f103c8effad560940264be9
https://doi.org/10.1093/carcin/bgi119
https://doi.org/10.1093/carcin/bgi119
Publikováno v:
Chemical Research in Toxicology. 16:1448-1454
1,3-Butadiene (BD) is a rodent and human carcinogen. While several epoxides formed during BD metabolism are mutagenic and may contribute to BD carcinogenicity, another proposed metabolite, hydroxymethylvinyl ketone (HMVK), could also be involved. A s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eed59a072358fd3f03e38a51e2cb0d9d
https://doi.org/10.1021/tx030021h
https://doi.org/10.1021/tx030021h
Autor:
Gary P. Carlson, Mark W. Powley
Publikováno v:
Inhalation Toxicology. 14:569-584
Benzene is an occupational hazard and environmental toxicant whose toxic effects are dependent on its metabolism by cytochrome P-450. Most physiologically based pharmacokinetic models assume that benzene is metabolized only in the liver. They may not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad8e18280d3ebaaecdc9a1e8c4e88141
https://doi.org/10.1080/08958370290084502
https://doi.org/10.1080/08958370290084502
Autor:
Mark W Powley, Gary P. Carlson
Publikováno v:
Toxicology Letters. 125:117-123
Benzene is an occupational and environmental toxicant. The major health concern for humans is acute myelogenous leukemia. To exert its toxic effects, benzene must be metabolized by cytochrome P450 to phenol and subsequently to catechol and hydroquino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0046a2807ee09a6907300d3cb634bf6
https://doi.org/10.1016/s0378-4274(01)00441-6
https://doi.org/10.1016/s0378-4274(01)00441-6
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 59:591-595
In mice, styrene is pneumotoxic, and there is some evidence of tumorigenicity. This toxicity is thought to be related to its bioactivation to styrene oxide in lung. To determine if human tissues have this capacity, the metabolism of styrene to styren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9aca9564ec99c9451373c8e068c9d17
https://doi.org/10.1080/009841000156600
https://doi.org/10.1080/009841000156600
Autor:
Mark W. Powley, Gary P. Carlson
Publikováno v:
Journal of Biochemical and Molecular Toxicology. 14:303-309
Benzene is an occupational hazard and environmental toxicant found in cigarette smoke, gasoline, and the chemical industry. The major health concern associated with benzene exposure is leukemia. The toxic effects of benzene are dependent on its metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::053090068823dcbb14a5614cd018419c
https://doi.org/10.1002/1099-0461(2000)14:6<303::aid-jbt2>3.0.co
https://doi.org/10.1002/1099-0461(2000)14:6<303::aid-jbt2>3.0.co
Autor:
Mark W. Powley, Gary P. Carlson
Publikováno v:
Toxicology. 139:207-217
Benzene is an occupational hazard and environmental toxicant found in cigarette smoke, gasoline, and the chemical industry. The major health concern associated with benzene exposure is leukemia. Studies using microsomal preparations from human, mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf56a9a49875419a9644ddfbfab68aa
https://doi.org/10.1016/s0300-483x(99)00134-1
https://doi.org/10.1016/s0300-483x(99)00134-1