A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors

Autor: Divyan A. Chopra, Kiran Sapkota, Mark W. Irvine, Guangyu Fang, David E. Jane, Daniel T. Monaghan, Shashank M. Dravid

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

Abstract NMDA receptors (NMDARs) contribute to several neuropathological processes. Novel positive allosteric modulators (PAMs) of NMDARs have recently been identified but their effects on NMDAR gating remain largely unknown. To this end, we tested t

Externí odkaz: https://doaj.org/article/9f33dc1aa5444fdbaec987412ab161fc

Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors

Autor: Minjun Li, David E. Jane, Graham L. Collingridge, Erica S. Burnell, Robert J. Thatcher, Kiran Sapkota, Arturas Volianskis, Daniel T. Monaghan, Noriko Simorowski, Hiro Furukawa, Mark W. Irvine, Jue Xiang Wang

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Wang, J X, Irvine, M W, Burnell, E S, Sapkota, K, Thatcher, R J, Li, M, Simorowski, N, Volianskis, A, Collingridge, G L, Monaghan, D T, Jane, D E & Furukawa, H 2020, ' Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors ', Nature Communications, vol. 11, no. 1, 423 . https://doi.org/10.1038/s41467-020-14321-0
Nature Communications

N-Methyl-D-aspartate receptors (NMDARs) play critical roles in the central nervous system. Their heterotetrameric composition generates subtypes with distinct functional properties and spatio-temporal distribution in the brain, raising the possibilit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a88f84ba3487ef9967bcf8d4394ee1ae

Pharmacological characterization of a novel negative allosteric modulator of NMDA receptors, UBP792

Autor: Shashank M. Dravid, Kiran Sapkota, Daniel T. Monaghan, Erica S. Burnell, David E. Jane, Mark W. Irvine, Guangyu Fang, Dinesh Y. Gawande

Publikováno v: Neuropharmacology. 201:108818

N-methyl- d -aspartate (NMDA) receptors (NMDARs) are a subtype of ionotropic glutamate receptor with important roles in CNS function. Since excessive NMDAR activity can lead to neuronal cell death and epilepsy, there is interest in developing NMDAR n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6206924b5904f9414ae8507790ab847
https://doi.org/10.1016/j.neuropharm.2021.108818

The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators

Autor: Kiran Sapkota, David E. Jane, Erica S. Burnell, Kim Dore, Guangyu Fang, Mark W. Irvine, Kang Tang, Daniel T. Monaghan, Roberto Malinow

Publikováno v: Sapkota, K, Dore, K, Tang, K, Irvine, M, Fang, G, Burnell, E S, Malinow, R, Jane, D E & Monaghan, D T 2019, ' The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators ', Biochemical Pharmacology, vol. 159, pp. 140-153 . https://doi.org/10.1016/j.bcp.2018.11.018

N-methyl-D-aspartate receptors (NMDARs) have multiple prominent roles in CNS function but their excessive or insufficient activity contributes to neuropathological/psychiatric disorders. Consequently, a variety of positive and negative allosteric mod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aedbdbc500f79f83e32b24bc6b51ca14
http://www.scopus.com/inward/record.url?scp=85058054700&partnerID=8YFLogxK

Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus

Autor: Grace France, Diego Fernández-Fernández, Erica S. Burnell, Mark W. Irvine, Daniel T. Monaghan, David E. Jane, Zuner A. Bortolotto, Graham L. Collingridge, Arturas Volianskis

Publikováno v: France, G, Fernández-Fernández, D, Burnell, E S, Irvine, M W, Monaghan, D T, Jane, D E, Bortolotto, Z A, Collingridge, G L & Volianskis, A 2017, ' Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus ', Neuropharmacology, vol. 112, no. A, pp. 76-83 . https://doi.org/10.1016/j.neuropharm.2016.08.010
Neuropharmacology

In the CA1 area of the hippocampus N-methyl-d-aspartate receptors (NMDARs) mediate the induction of long-term depression (LTD), short-term potentiation (STP) and long-term potentiation (LTP). All of these forms of synaptic plasticity can be readily s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b0cfa12bab14e125d69009e9c837cc