Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Mark W. Hamblin"'
Autor:
Pramod R. Saxena, Patrick P.A. Humphrey, Joël Bockaert, Rebecca Hills, Sleight Andrew, Rodrigo Andrade, Amy S. Butler, Bryan L. Roth, Graeme R. Martin, Frank D. Yocca, Stephen J. Peroutka, Manfred Göthert, Julie Hensler, Carlos M. Villalón, Katharine Herrick-Davis, Luc Maroteaux, Richard M. Eglen, Paul R. Hartig, Nicholas M. Barnes, M. Hamon, Theresa Branchek, Aline Dumuis, Klaus Peter Latté, Mark W. Hamblin, Trevor Sharp, Ewan J. Mylecharane, John F. Neumaier, René Hen, John A. Peters, Marlene L. Cohen, Derek N. Middlemiss, Gordon Baxter, Daniel Hoyer
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2019
5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [194] and subsequently revised [176]) are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine. The diversi
Autor:
Ljiljana Mladenovic, Jean-Claude Béïque, Mark W. Hamblin, Paul Perring, Brian M. Campbell, Rodrigo Andrade, Paul C. Walker
Publikováno v:
The Journal of Neuroscience. 24:4807-4817
The developing prefrontal cortex receives a dense serotonergic innervation, yet little is known about the actions of serotonin [5-Hydroxytryptamine (5-HT)] in this region during development. Here, we examined the developmental regulation of 5-HT rece
Autor:
Bryan L. Roth, Mark A. Metcalf, Naseem Khan, Teresa Druck, Herbert Y. Meltzer, Mark W. Hamblin, Ruth Kohen, Kay Huebner, Jean E. Lachowicz, David R. Sibley
Publikováno v:
Journal of Neurochemistry. 66:47-56
We describe the cloning and characterization of a human 5-HT6 serotonin receptor. The open reading frame is interrupted by two introns in positions corresponding to the third cytoplasmic loop and the third extracellular loop. The human 5-HT6 cDNA enc
Publikováno v:
Molecular Brain Research. 90:110-117
We have cloned the mouse 5-HT 6 serotonin receptor and examined structure–function relationships in the C-terminal end of the third cytoplasmic (CIII) loop, introducing point mutations by site-directed mutagenesis at positions 264 to 268. We examin
Publikováno v:
Molecular Brain Research. 82:65-73
The role of mineralocorticoid and glucocorticoid receptors (MR and GR, respectively) in the regulation of serotonin receptors has not been clearly delineated. There is no consensus regarding the regulation of 5-HT(1A) receptors, and corticosteroid re
Publikováno v:
Annals of the New York Academy of Sciences. 861:31-37
Three distinct mammalian Gs coupled serotonin receptor genes have been identified, 5-HT4, 5-ht6, and 5-HT7, which produce at least seven different functional receptors through alternative splicing. One of the chief questions facing workers in this ar
Publikováno v:
Neuropsychopharmacology. 15:515-522
In major depression in humans and in animal models of depression, there is a defect in serotonergic neurotransmission that can be relieved by chronic antidepressant treatment. One possibility is that this pathologic state is caused by excessive presy
Publikováno v:
Brain Research. 722:50-58
The rat 5-HT1B receptor (also referred to as the 5-HT1D beta receptor) is expressed in both serotonergic and nonserotonergic neurons in the rat brain, where it has been hypothesized to inhibit the release of neurotransmitters from axonal terminals. I
Autor:
Yong Shen, Pedro A. Jose, David R. Sibley, Mark W. Hamblin, Frederick J. Monsma, Mark A. Metcalf
Publikováno v:
Journal of Biological Chemistry. 268:18200-18204
We have utilized the polymerase chain reaction technique to selectively amplify a G protein-coupled receptor cDNA from rat kidney proximal convoluted tubule mRNA, which exhibits high homology with previously cloned serotonin receptors. Sequencing of
Autor:
Govind T. Vatassery, Mark W. Hamblin, Kalpana M. Merchant, Daniel M. Dorsa, Maurice W. Dysken, Dorcas J. Dobie
Publikováno v:
Brain Research. 616:105-113
Neuroleptic drugs such as haloperidol (H) induce a rapid increase in neurotensin/neuromedin N (NT/N) gene expression in the dorsolateral striatum (DLSt) and nucleus accumbens (NA) in young adult rats. This effect may be mediated by post-receptor effe