Zobrazeno 1 - 10
of 239
pro vyhledávání: '"Mark W. Hall"'
Autor:
Mihir R. Atreya, Shayantan Banerjee, Andrew J. Lautz, Matthew N. Alder, Brian M. Varisco, Hector R. Wong, Jennifer A. Muszynski, Mark W. Hall, L. Nelson Sanchez-Pinto, Rishikesan Kamaleswaran, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Scott L. Weiss, Michael T. Bigham, Parag N. Jain, Adam J. Schwarz, Riad Lutfi, Jeffrey Nowak, Geoffrey L. Allen, Neal J. Thomas, Jocelyn R. Grunwell, Torrey Baines, Michael Quasney, Bereketeab Haileselassie, Chris J. Lindsell
Publikováno v:
EBioMedicine, Vol 99, Iss , Pp 104938- (2024)
Summary: Background: Multiple organ dysfunction syndrome (MODS) disproportionately drives morbidity and mortality among critically ill patients. However, we lack a comprehensive understanding of its pathobiology. Identification of genes associated wi
Externí odkaz:
https://doaj.org/article/162e22e81e7c4a51b9298a80581e6c4c
Autor:
Tanya Novak, Jeremy Chase Crawford, Georg Hahn, Mark W. Hall, Simone A. Thair, Margaret M. Newhams, Janet Chou, Peter M. Mourani, Keiko M. Tarquinio, Barry Markovitz, Laura L. Loftis, Scott L. Weiss, Renee Higgerson, Adam J. Schwarz, Neethi P. Pinto, Neal J. Thomas, Rainer G. Gedeit, Ronald C. Sanders, Sidharth Mahapatra, Bria M. Coates, Natalie Z. Cvijanovich, Kate G. Ackerman, David W. Tellez, Patrick McQuillen, Stephen C. Kurachek, Steven L. Shein, Christoph Lange, Paul G. Thomas, Adrienne G. Randolph
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundInfluenza virus is responsible for a large global burden of disease, especially in children. Multiple Organ Dysfunction Syndrome (MODS) is a life-threatening and fatal complication of severe influenza infection.MethodsWe measured RNA expres
Externí odkaz:
https://doaj.org/article/1b310ffd8aa249aa92844aef701a6cc3
Autor:
Katherine E. Bline, Melissa Moore-Clingenpeel, Josey Hensley, Lisa Steele, Kristin Greathouse, Larissa Anglim, Lisa Hanson-Huber, Jyotsna Nateri, Jennifer A. Muszynski, Octavio Ramilo, Mark W. Hall
Publikováno v:
Critical Care, Vol 24, Iss 1, Pp 1-7 (2020)
Abstract Background Severe critical illness-induced immune suppression, termed immunoparalysis, is associated with longer duration of organ dysfunction in septic children. mRNA studies have suggested differential benefit of hydrocortisone in septic c
Externí odkaz:
https://doaj.org/article/8ee33637ea3442c9bfd96ae18d8cba0e
Autor:
Alon Geva, Manish M. Patel, Margaret M. Newhams, Cameron C. Young, Mary Beth F. Son, Michele Kong, Aline B. Maddux, Mark W. Hall, Becky J. Riggs, Aalok R. Singh, John S. Giuliano, Charlotte V. Hobbs, Laura L. Loftis, Gwenn E. McLaughlin, Stephanie P. Schwartz, Jennifer E. Schuster, Christopher J. Babbitt, Natasha B. Halasa, Shira J. Gertz, Sule Doymaz, Janet R. Hume, Tamara T. Bradford, Katherine Irby, Christopher L. Carroll, John K. McGuire, Keiko M. Tarquinio, Courtney M. Rowan, Elizabeth H. Mack, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Philip C. Spinella, Mary A. Staat, Katharine N. Clouser, Vijaya L. Soma, Heda Dapul, Mia Maamari, Cindy Bowens, Kevin M. Havlin, Peter M. Mourani, Sabrina M. Heidemann, Steven M. Horwitz, Leora R. Feldstein, Mark W. Tenforde, Jane W. Newburger, Kenneth D. Mandl, Adrienne G. Randolph
Publikováno v:
EClinicalMedicine, Vol 40, Iss , Pp 101112- (2021)
Background: Multisystem inflammatory syndrome in children (MIS-C) consensus criteria were designed for maximal sensitivity and therefore capture patients with acute COVID-19 pneumonia. Methods: We performed unsupervised clustering on data from 1,526
Externí odkaz:
https://doaj.org/article/0da407d35ec1438f995441c601ff9850
Autor:
Andrew Snyder, Kathleen Jedreski, James Fitch, Saranga Wijeratne, Amy Wetzel, Josey Hensley, Margaret Flowers, Katherine Bline, Mark W. Hall, Jennifer A. Muszynski
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundSevere innate immune suppression, termed immunoparalysis, is associated with increased risks of nosocomial infection and mortality in children with septic shock. Currently, immunoparalysis cannot be clinically diagnosed in children, and mec
Externí odkaz:
https://doaj.org/article/e686a6f9e09048279cf9d5fb6957310a
Autor:
Neethi P. Pinto, Robert A. Berg, Athena F. Zuppa, Christopher J. Newth, Murray M. Pollack, Kathleen L. Meert, Mark W. Hall, Michael Quasney, Anil Sapru, Joseph A. Carcillo, Patrick S. McQuillen, Peter M. Mourani, Ranjit S. Chima, Richard Holubkov, Vinay M. Nadkarni, Ron W. Reeder, Jerry J. Zimmerman, the Life After Pediatric Sepsis Evaluation (LAPSE) Investigators
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2021)
Background: Although some pediatric sepsis survivors experience worsening health-related quality of life (HRQL), many return to their pre-illness HRQL. Whether children can improve beyond baseline is not known. We examined a cohort of pediatric sepsi
Externí odkaz:
https://doaj.org/article/dff56ddf4f7448f48f5a395f34c7963e
Autor:
Michaël S. Sauthier, MD MBI, Philippe A. Jouvet, MD, PhDMBA, Margaret M. Newhams,, MPH, Adrienne G. Randolph, MD, MSc, for the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Pediatric Intensive Care Influenza (PICFLU) Network Investigators, Michele Kong, Ronald C. Sanders, Jr, Olivia K. Irby, David Tellez, Katri Typpo, Barry Markovitz, Natalie Cvijanovich, Heidi Flori, Adam Schwarz, Nick Anas, Patrick McQuillen, Peter Mourani, John S. Giuliano, Jr., Gwenn McLaughlin, Matthew Paden, Keiko Tarquinio, Bria M. Coates, Neethi Pinto, Juliane Bubeck Wardenburg, Janice Sullivan, Vicki Montgomery, Adrienne G. Randolph, Anna A. Agan, Tanya Novak, Margaret M. Newhams, Melania Bembea, Sapna R. Kudchadkar, Stephen C. Kurachek, Mary E. Hartman, Edward J. Truemper, Sidharth Mahapatra, Sholeen Nett, Daniel L. Levin, Kate G. Ackerman, Ryan Nofziger, Steven L. Shein, Mark W. Hall, Neal Thomas, Scott L. Weiss, Julie Fitzgerald, Renee Higgerson, Laura L. Loftis, Rainer G. Gedeit
Publikováno v:
Critical Care Explorations, Vol 2, Iss 8, p e0175 (2020)
Background:. Influenza virus is a major cause of acute hypoxemic respiratory failure. Early identification of patients who will suffer severe complications can help stratify patients for clinical trials and plan for resource use in case of pandemic.
Externí odkaz:
https://doaj.org/article/ca6d7df3e8c14e91a9b1f188a01d97ae
Autor:
Kusum Menon, MD, MSc, Luregn J. Schlapbach, MD, Samuel Akech, MBChB, MMED, Andrew Argent, MBBCh, MD, Kathleen Chiotos, MD, MSCE, Mohammod Jobayer Chisti, MBBS, MMed, PhD, Jemila Hamid, PhD, Paul Ishimine, MD, Niranjan Kissoon, MD, Rakesh Lodha, MD, Cláudio Flauzino Oliveira, MD, Mark Peters, MBChB, PhD, Pierre Tissieres, MD, PhD, R. Scott Watson, MD, MPH, Matthew O. Wiens, PharmD, PhD, James L. Wynn, MD, Lauren R. Sorce, BSN, PhD, for the Pediatric Sepsis Definition Taskforce of the Society of Critical Care Medicine, Luregn J. Schlapbach, R. Scott Watson, Andrew Argent, Lauren R. Sorce, Elizabeth R. Alpern, Fran Balamuth, Tellen D. Bennett, Paolo Biban, Joe Carcillo, Enitan Carrol, Kathleen Chiotos, Mohammod Jobayer Chisti, Idris Evans, Lu Guoping, Mark W. Hall, David Inwald, Paul Ishimine, Michael Levin, Niranjan (Tex) Kissoon, Rakesh Lodha, Kathryn Maitland, Simon Nadel, Satoshi Nakagawa, Claudio Flauzino Oliveira, Mark Peters, Adrienne G. Randolph, Suchitra Ranjit, L. Nelson Sanchez-Pinto, Halden F. Scott, Daniela Carla Souza, Paul Tissieres, Juliane Bubeck Wardenburg, Scott L. Weiss, Wilson Milton Were, Matt Wiens, James L. Wynn, Jerry J. Zimmerman
Publikováno v:
Critical Care Explorations, Vol 2, Iss 6, p e0123 (2020)
Objectives:. Sepsis is responsible for a substantial proportion of global childhood morbidity and mortality. However, evidence demonstrates major inaccuracies in the use of the term “sepsis” in clinical practice, coding, and research. Current and
Externí odkaz:
https://doaj.org/article/696a47b9bd404f98a5cb348432580fe7
Publikováno v:
Pathogens, Vol 10, Iss 10, p 1239 (2021)
The inflammatory response in pediatric sepsis is highly dynamic and includes both pro- and anti-inflammatory elements that involve the innate and adaptive immune systems. While the pro-inflammatory response is responsible for the initial clinical sig
Externí odkaz:
https://doaj.org/article/71d7687ae26e4fcb9cff41bd4615e1b7
Autor:
Emily R. Levy, Wai-Ki Yip, Michael Super, Jill M. Ferdinands, Anushay J. Mistry, Margaret M. Newhams, Yu Zhang, Helen C. Su, Gwenn E. McLaughlin, Anil Sapru, Laura L. Loftis, Scott L. Weiss, Mark W. Hall, Natalie Cvijanovich, Adam Schwarz, Keiko M. Tarquinio, Peter M. Mourani, PALISI PICFLU Investigators, Adrienne G. Randolph
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Background: Mannose-binding lectin (MBL) is an innate immune protein with strong biologic plausibility for protecting against influenza virus-related sepsis and bacterial co-infection. In an autopsy cohort of 105 influenza-infected young people, carr
Externí odkaz:
https://doaj.org/article/ecd1e53a62ae49fba1fe032cd62b2463