Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Mark W. Fleck"'
Autor:
Mark W. Fleck, Jessica L. Nuwer
Publikováno v:
Channels. 13:440-454
Pentameric GABAA receptors are composed from 19 possible subunits. The GABAA β subunit is unique because the β1 and β3 subunits can assemble and traffic to the cell surface as homomers, whereas most of the other subunits, including β2, are hetero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f42ef0c31044b444e5cd423058080eac
https://doi.org/10.1080/19336950.2019.1676368
https://doi.org/10.1080/19336950.2019.1676368
Publikováno v:
Biochemical Pharmacology. 83:1127-1135
There is ample pharmacological and physiological evidence for yet unidentified histamine receptors in mammalian brain that are linked to a Cl(-) conductance. In invertebrates, two histamine-gated chloride channels (HisCl α1 and α2) are already well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80a32eb821b632086d772b57368e2847
https://doi.org/10.1016/j.bcp.2011.12.011
https://doi.org/10.1016/j.bcp.2011.12.011
Autor:
Mark W. Fleck
Publikováno v:
Ionotropic Glutamate Receptor Technologies ISBN: 9781493928118
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17710fdb2418e1bf830eca802e1882d2
https://doi.org/10.1007/978-1-4939-2812-5_13
https://doi.org/10.1007/978-1-4939-2812-5_13
Autor:
Tara M. Kistler, Mark W. Fleck
Publikováno v:
Channels. 1:417-428
Differences in binding-site residues of GluR2 (AMPAR) and GluR6 (KAR) subunits have been identified that might account for their functional and pharmacological differences. Specifically, residues A518, A689 and N721 in GluR6 replace highly conserved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8c48e20ebe142d236b9363e018ee9a
https://doi.org/10.4161/chan.1.6.5589
https://doi.org/10.4161/chan.1.6.5589
Autor:
Werner Sieghart, Margot Ernst, Lindsay B. Hough, Joachim Ramerstorfer, Paul Hoerbelt, Jeffrey L. Thomson, Mark W. Fleck
Publikováno v:
Neuropharmacology. 108
Histamine is an important neurotransmitter that exerts its physiological actions through H1-4 metabotropic receptors in mammals. It also directly activates ionotropic GABAA receptor (GABAAR) β3 homooligomers and potentiates GABA responses in αβ he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d4995d4207cc1762500e361da3ec2e
https://pubmed.ncbi.nlm.nih.gov/27140694
https://pubmed.ncbi.nlm.nih.gov/27140694
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(8)
Dopamine is a critical neuromodulator that activates GPCRs in mammals or ligand-gated ion channels in invertebrates. The present study demonstrates that dopamine (0.1–10 mm) exerts novel, opposing effects on different populations of mammalian (rat)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a448def89c4bc1ae2ba2f4e14dbc56
https://pubmed.ncbi.nlm.nih.gov/25716851
https://pubmed.ncbi.nlm.nih.gov/25716851
Autor:
Martin E. Kuehne, Patrick A. Jokiel, Mark W. Fleck, Liwen He, Stanley D. Glick, Christopher J. Pace, Isabelle M. Maisonneuve
Publikováno v:
European Journal of Pharmacology. 492:159-167
18-Methoxycoronaridine, a novel iboga alkaloid congener, reduces drug self-administration in animal models of addiction. Previously, we proposed that these effects are mediated by the ability of 18-methoxycoronaridine to inhibit nicotinic alpha3beta4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd90c382821594fd402e5f46ab121720
https://doi.org/10.1016/j.ejphar.2004.03.062
https://doi.org/10.1016/j.ejphar.2004.03.062
Autor:
Patrick A. Jokiel, Liwen He, Stanley D. Glick, I. M. Maisonneuve, Jean M. Bidlack, C. J. Pace, Martin E. Kuehne, Mark W. Fleck
Publikováno v:
Journal of Medicinal Chemistry. 46:2716-2730
Variation of the methoxycarbonyl and C-18 substituents of the antiaddictive compound 18-methoxycoronaridine, and contraction of its isoquinuclidine ring segment, provided 15 congeners for SAR evaluation at opioid and alpha3beta4 nicotinic acetylcholi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32e98e665dcfea1fa464d5221c911074
https://doi.org/10.1021/jm020562o
https://doi.org/10.1021/jm020562o
Publikováno v:
Neurochemistry International. 39:75-81
This study examined whether preaccumulated d , l - threo -s-hydroxyaspartate (tHA), a competitive substrate for the high-affinity excitatory amino acid (EAA) transporter, is released as a false transmitter from EAA-releasing nerve terminals. Potassiu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5303396eec6ecaf7313c6a0511575967
https://doi.org/10.1016/s0197-0186(00)00111-x
https://doi.org/10.1016/s0197-0186(00)00111-x
Autor:
Michael J. Gambello, Anthony Wynshaw-Boris, Mark W. Fleck, Gregory J. Bix, David H. Ledbetter, Amy Chen, Chris J. McBain, Shinji Hirotsune, Gary D. Clark
Publikováno v:
Nature Genetics. 19:333-339
Heterozygous mutation or deletion of the beta subunit of platelet-activating factor acetylhydrolase (PAFAH1B1, also known as LIS1) in humans is associated with type I lissencephaly, a severe developmental brain disorder thought to result from abnorma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc8830a8be6065c3e5969a463a78693
https://doi.org/10.1038/1221
https://doi.org/10.1038/1221