Výsledky vyhledávání - "Mark W. Farmen"

Nonclinical pharmacology and toxicology of the first biosimilar insulin glargine drug product (BASAGLAR ® /ABASAGLAR ® ) approved in the European Union

Autor: Jamie L. Blackbourne, David E. Coutant, Julie S. Moyers, Owens Rebecca Anne, M. Dodson Michael, Richard A. Byrd, A. Eric Schultze, John L. Vahle, Michael K. Sievert, Niraj Tripathi, Mark W. Farmen

Publikováno v: Regulatory Toxicology and Pharmacology. 88:56-65

Basaglar®/Abasaglar® (Lilly insulin glargine [LY IGlar]) is a long-acting human insulin analogue drug product granted marketing authorisation as a biosimilar to Lantus® (Sanofi insulin glargine [SA IGlar]) by the European Medicines Agency. We asse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da1e31f53c987023a1ffe89a88e5134b
https://doi.org/10.1016/j.yrtph.2017.05.013

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In Vivo and In Vitro Characterization of Basal Insulin Peglispro: A Novel Insulin Analog

Autor: John Michael Beals, Hui-Rong Qian, Steven D. Kahl, Xiaoping Ruan, Gordon B. Cutler, Andrew Mark Vick, Owens Rebecca Anne, Julie S. Moyers, Mark W. Farmen, M. Dodson Michael, Shun Li, Ryan John Hansen, Chen Zhang, Anja Koester

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 357:459-465

The aim of this research was to characterize the in vivo and in vitro properties of basal insulin peglispro (BIL), a new basal insulin, wherein insulin lispro was derivatized through the covalent and site-specific attachment of a 20-kDa polyethylene-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c2025f98992771961b7f38e68e34dd
https://doi.org/10.1124/jpet.115.231035

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Deciphering ADME genetic data using an automated haplotype approach

Autor: Mark W. Farmen, Michelle A. Penny, Kathleen M. Hillgren, Hsiu-Yung C. Lee, Stewart L. Fossceco, Yan Jin, Yingying Guo

Publikováno v: Pharmacogenetics and Genomics. 24:292-305

Objective To investigate the utility of statistical tools in translating Affymetrix Drug Metabolizing Enzyme and Transporter (DMET) Assay single-nucleotide polymorphisms (SNPs) into common consensus star alleles. Methods DMET SNP data from clinical t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f58b79a62bcd647c19d4cafbcc7ecff
https://doi.org/10.1097/fpc.0000000000000047

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The Rat microRNA body atlas; Evaluation of the microRNA content of rat organs through deep sequencing and characterization of pancreas enriched miRNAs as biomarkers of pancreatic toxicity in the rat and dog

Autor: Sachin Mathur, Florian Caiment, Craig Fisher, Erik Koenig, David Greg Hall, Patrick Kirby, David E. Watson, Aaron P. Smith, Mark W. Farmen, John N. Calley, Pierre R. Bushel, Han Wu, Jianying Li, Hui-Rong Qian

Publikováno v: BMC Genomics
BMC Genomics, 17:694. BioMed Central Ltd

Background MicroRNAs (miRNA) are ~19–25 nucleotide long RNA molecules that fine tune gene expression through the inhibition of translation or degradation of the mRNA through incorporation into the RNA induced silencing complex (RISC). MicroRNAs are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f3f15378f8f133a3860806b066eda1
https://doi.org/10.1186/s12864-016-2956-z

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Genetic Association Study of Treatment Response With Olanzapine/Fluoxetine Combination or Lamotrigine in Bipolar I Depression

Autor: John P. Houston, Roy H. Perlis, Bonnie Fijal, David H. Adams, Virginia K. Sutton, Mark W. Farmen, Alan Breier

Publikováno v: The Journal of Clinical Psychiatry. 71:599-605

Objective To evaluate common genetic variations for association with symptomatic improvement in bipolar I depression following treatment with olanzapine/fluoxetine combination (OFC) or lamotrigine. Method Symptom improvement was assessed in 88 OFC-tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be2efa099bed91738a85eb91c0c3f13
https://doi.org/10.4088/jcp.08m04632gre

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Dopamine receptor D3 genotype association with greater acute positive symptom remission with olanzapine therapy in predominately caucasian patients with chronic schizophrenia or schizoaffective disorder

Autor: John P. Houston, Alan Breier, Sandra L Close, Ann Catherine M. Downing, Mark W. Farmen, David H. Adams

Publikováno v: Human Psychopharmacology: Clinical and Experimental. 23:267-274

Objective To test association of dopamine receptor D3 (DRD-3) gene polymorphisms with olanzapine response in genetic samples from a registration phase clinical trial. Methods Eighty-eight acutely ill patients with schizophrenia or schizoaffective dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f19a3b02a406bdf074519340c2785b5
https://doi.org/10.1002/hup.930

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A phase I dose-escalation study to a predefined dose of a transforming growth factor-β1 monoclonal antibody (TβM1) in patients with metastatic cancer

Autor: Michael Lahn, Donald A. Richards, Paul Conkling, Mark W. Farmen, Ann Cleverly, Sunil Kadam, Durisala Desaiah, Kristen E. Williams, R. N. Raju, Celine Pitou, Allen Lee Cohn

Publikováno v: International Journal of Oncology

Transforming growth factor β (TGF-β) plays an important role in cancer. Monoclonal antibodies (mAb) designed to specifically block the TGF-β ligands, are expected to inhibit tumor progression in patients with metastatic cancer. TβM1 is a humanize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efbd08ec3829ab6bd83870848e87e011
https://pubmed.ncbi.nlm.nih.gov/25270361

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Analysis of a Large Structure/Biological Activity Data Set Using Recursive Partitioning

Autor: Mark W. Farmen, S. Stanley Young, Christophe G. Lambert, Andrew Rusinko, Paul L. Brown

Publikováno v: Journal of Chemical Information and Computer Sciences. 39:1017-1026

Combinatorial chemistry and high-throughput screening are revolutionizing the process of lead discovery in the pharmaceutical industry. Large numbers of structures and vast quantities of biological assay data are quickly being accumulated, overwhelmi

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https://doi.org/10.1021/ci9903049

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