Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Mark W. Becher"'
Autor:
Ami Mankodi, Thurman M. Wheeler, Reena Shetty, Kelly M. Salceies, Mark W. Becher, Charles A. Thornton
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 1, Pp 539-546 (2012)
The genetic basis of oculopharyngeal muscular dystrophy (OPMD) is a short expansion of a polyalanine tract (normal allele: 10 alanines, mutant allele: 11–17 alanines) in the nuclear polyadenylate binding protein PABPN1 which is essential for contro
Externí odkaz:
https://doaj.org/article/ce060d860a204c9f87a2e6b85706322f
Autor:
David R. Borchelt, Philip C. Wong, Mark W. Becher, Carlos A. Pardo, Michael K. Lee, Zuo-Shang Xu, Gopal Thinakaran, Nancy A. Jenkins, Neal G. Copeland, Sangram S. Sisodia, Don W. Cleveland, Donald L. Price, Paul N. Hoffman
Publikováno v:
Neurobiology of Disease, Vol 5, Iss 1, Pp 27-35 (1998)
Superoxide dismutase 1 (SOD1), a ubiquitously expressed enzyme, detoxifies superoxide radicals and participates in copper homeostasis. Mutations in this enzyme have been linked to a subset of autosomal dominant cases of familial amyotrophic lateral s
Externí odkaz:
https://doaj.org/article/a84e546c32874331bb3496288a06ce73
Autor:
Mark W. Becher, Joyce A. Kotzuk, Alan H. Sharp, Stephen W. Davies, Gillian P. Bates, Donald L. Price, Christopher A. Ross
Publikováno v:
Neurobiology of Disease, Vol 4, Iss 6, Pp 387-397 (1998)
Huntington's disease (HD) is caused by CAG triplet repeat expansion inIT15which leads to polyglutamine stretches in the HD protein product, huntingtin. The pathological hallmark of HD is the degeneration of subsets of neurons, primarily those in the
Externí odkaz:
https://doaj.org/article/752dd6562367466680a45503efc413c8
Autor:
Edmar Tavares da Costa, Michael Wilson, C. Fernando Valenzuela, Zoltán Molnár, Mark W. Becher, L. Donald Partridge, Guillermina López-Bendito, Mario Carta, Peter M. Thompson M.D., Philip Washbourne, James R. Mathews
Axon outgrowth during development and neurotransmitter release depends on exocytotic mechanisms, although what protein machinery is common to or differentiates these processes remains unclear. Here we show that the neural t-SNARE (target-membrane-ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e586e4c1db7b283e1098b3ec0588c57
https://doi.org/10.1038/nn783
https://doi.org/10.1038/nn783
Publikováno v:
Journal of Histotechnology. 30:67-78
Specialized histology techniques are central to the practice of the study of diseases of the central nervous system in the pathology subspecialty of neuropathology. Many of the special stains, enzyme histochemistries, and immunohistochemical stains p
Publikováno v:
Annals of Neurology. 48:812-815
Intranuclear inclusions are one of the ultrastructural hallmarks of oculopharyngeal muscular dystrophy (OPMD), a disorder caused by small polyalanine (GCG) expansions in the gene that codes for a ubiquitous nuclear protein called poly(A) binding prot
Autor:
David R. Borchelt, Donald L. Price, Tamara Ratovitski, Christopher A. Ross, Joyce A. Kotzuk, K. Duan, Neal G. Copeland, Hilda H. Slunt, Alan H. Sharp, Nancy A. Jenkins, Mark W. Becher, Hyder A. Jinnah, Jillian K. Cooper, Gabriele Schilling
Publikováno v:
Human Molecular Genetics. 8:397-407
Huntington's disease (HD) is an inherited, neurodegenerative disorder caused by the expansion of a glutamine repeat in the N-terminus of the huntingtin protein. To gain insight into the pathogenesis of HD, we generated transgenic mice that express a
Publikováno v:
Journal of Histotechnology. 30:131-133
We have adapted a cornmercially available tissue processing cessing material, HistoGel™, for the routine processing of stereotactic brain needle biopsies and transsphenoidal pituitary gland specimens. Both of these specimen types often result in ve
Autor:
Ali H. Rajput, Alex Rajput, Anthony E. Lang, Rajeev Kumar, Ryan J. Uitti, David G. Le Couteur, Sally J. McCann, Mark W. Becher, Christopher A. Ross, Richard Hardie
Publikováno v:
Movement Disorders. 13:851-854
Autor:
Paul N. Hoffman, Gopal Thinakaran, Carlos A. Pardo, Philip C. Wong, Donald L. Price, Sangram S. Sisodia, Zuoshang Xu, Nancy A. Jenkins, Neal G. Copeland, Don W. Cleveland, Mark W. Becher, Michael K. Lee, David R. Borchelt
Publikováno v:
Neurobiology of Disease, Vol 5, Iss 1, Pp 27-35 (1998)
Superoxide dismutase 1 (SOD1), a ubiquitously expressed enzyme, detoxifies superoxide radicals and participates in copper homeostasis. Mutations in this enzyme have been linked to a subset of autosomal dominant cases of familial amyotrophic lateral s