Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Mark W, Trumbore"'
Publikováno v:
Journal of Cellular Physiology. 182:256-268
Our study examines the effect of apoptosis on prothymosin alpha, an abundant, nuclear protein intimately involved with proliferation of all mammalian cells. When HeLa cells were treated with actinomycin D, with etoposide, or with staurosporine follow
Publikováno v:
Drugs. 59:9-16
Membrane Biophysical Interactions of Amlodipine Result in Antioxidant PropertiesObjectiveTo assess the potential benefits of the antioxidant activity of certain pharmacological agents that may be beneficial in the treatment of cardiovascular disease,
Publikováno v:
The American Journal of Cardiology. 84:16-22
The antioxidant activities of representative calcium antagonists, including amlodipine, verapamil, and diltiazem, were measured in hepatic microsomal membranes by the Fe-catalyzed, hydroxyl radical–producing system (dihydroxyfumarate + Fe 3+ ) and
Publikováno v:
Journal of Cellular Physiology. 178:154-163
Prothymosin alpha gene expression accompanies growth of all mammalian cells. The protein, which is abundant, exceedingly acidic, and localized to the nucleus, is further distinguished by the presence of clustered phosphorylated glutamic acid residues
Publikováno v:
Protein Expression and Purification. 13:383-388
According to published accounts, prothymosin alpha exhibits high evolutionary conservation from yeast to man (Makarova, T., Grebenshikov, N., Egorov, C., Vartapetian, A., and Bogdanov, A. FEBS Lett. 257, 247-250, 1989). We report here our failure to
Autor:
Mark W. Trumbore, R. Preston Mason
Publikováno v:
Biochemical Pharmacology. 51:653-660
Lipid peroxidation causes cellular damage during aging and various diseases, including atherosclerosis. Chronic administration of highly lipophilic calcium channel blockers (CCB) may reduce lipid peroxidation as a result of concentration in cell memb
Publikováno v:
Neurobiology of Aging. 16:531-539
Phosphoserine (L-PS) is among several phosphomonoesters found to be elevated in autopsied Alzheimer's disease (AD) brain tissue. To investigate the molecular interactions of L-PS with membrane lipid bilayers, small angle X-ray diffraction and high re
Autor:
Ellen, Frankel, Mark W, Trumbore
Publikováno v:
The Journal of clinical and aesthetic dermatology. 2(4)
Objective: This study evaluated a unique formulation of lidocaine 4% in an emollient aerosol foam microemulsion system to facilitate rapid delivery of the active ingredient and reduce pain associated with cosmetic dermatologic laser treatment. Design
Publikováno v:
Journal of drugs in dermatology : JDD. 8(3)
Acne rosacea is a chronic cutaneous disorder affecting as many as 14 million Americans. Papulopustular rosacea is the classic form of rosacea characterized by papules, pustules, and erythema. The skin barrier deficiency and vascular hyperactivity cha
Prothymosin alpha is a nonspecific facilitator of nuclear processes: studies of run-on transcription
Autor:
Shelby L. Berger, Mark W. Trumbore
Publikováno v:
Protein expression and purification. 20(3)
The effect of prothymosin alpha on transcriptional elongation has been examined. The addition of prothymosin alpha to COS-1 and NIH3T3 cell nuclei engaged in run-on transcription stimulated RNA synthesis approximately two- to threefold in a dose-depe