Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Mark W, Ruszczycky"'
Autor:
Bidhan Chandra De, Wenjun Zhang, Chunfang Yang, Attila Mándi, Chunshuai Huang, Liping Zhang, Wei Liu, Mark W. Ruszczycky, Yiguang Zhu, Ming Ma, Ghader Bashiri, Tibor Kurtán, Hung-wen Liu, Changsheng Zhang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Epoxide ring opening reactions are important in both biological processes and synthetic applications. Here, the authors show that flavin cofactors can catalyze reductive and oxidative epoxide ring opening reactions and propose the underlying mechanis
Externí odkaz:
https://doaj.org/article/fb5a7530f2fc41d8bb074811b01d97b6
Autor:
Jiawei Zhang, Xueli Hou, Zhang Chen, Yeonjin Ko, Mark W. Ruszczycky, Yutian Chen, Jiahai Zhou, Hung-wen Liu
Publikováno v:
Journal of the American Chemical Society. 144:9910-9919
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::832b5de18f15e4120323d9cd1b6a1863
https://doi.org/10.1021/jacs.2c02676
https://doi.org/10.1021/jacs.2c02676
Autor:
Yu-Hsuan Lee, Xueli Hou, Ridao Chen, Jianqiang Feng, Xiao Liu, Mark W. Ruszczycky, Jin-Ming Gao, Binju Wang, Jiahai Zhou, Hung-wen Liu
Publikováno v:
Journal of the American Chemical Society. 144:4478-4486
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e696b41b5ccbc288541ec47f7594b99
https://doi.org/10.1021/jacs.1c12010
https://doi.org/10.1021/jacs.1c12010
Autor:
Yu-Hsuan, Lee, Xueli, Hou, Ridao, Chen, Jianqiang, Feng, Xiao, Liu, Mark W, Ruszczycky, Jin-Ming, Gao, Binju, Wang, Jiahai, Zhou, Hung-Wen, Liu
Publikováno v:
J Am Chem Soc
The biosynthesis of blasticidin S has drawn attention due to the participation of the radical SAM enzyme BlsE. The original assignment of BlsE as a radical mediated, redox neutral decarboxylase is unusual, because this reaction appears to serve no bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::984b799aaa1e29a25df578e1fabcd9e4
https://pubmed.ncbi.nlm.nih.gov/35238201
https://pubmed.ncbi.nlm.nih.gov/35238201
Autor:
Mark W. Ruszczycky, Minje Kim, Hung-wen Liu, Yasushi Ogasawara, Shao-An Wang, Yeonjin Ko, Daan Ren
Publikováno v:
Proceedings of the National Academy of Sciences. 117:10265-10270
Coformycin and pentostatin are structurally related N-nucleoside inhibitors of adenosine deaminase characterized by an unusual 1,3-diazepine nucleobase. Herein, the cof gene cluster responsible for coformycin biosynthesis is identified. Reconstitutio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b9c1d99286f6f697e621a97ac111135
https://doi.org/10.1073/pnas.2000111117
https://doi.org/10.1073/pnas.2000111117
Autor:
Ronald Besandre, Zhang Chen, Mark W. Ruszczycky, Hung-wen Liu, Aimin Liu, Jiawei Zhang, Ian Davis
Publikováno v:
J Am Chem Soc
HygY is a SPASM/twitch radical SAM enzyme hypothesized to catalyze the C2′-epimerization of galacamine during the biosynthesis of hygromycin B. This activity is confirmed via biochemical and structural analysis of the derivatized reaction products
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d8857fc0f7f6cd903889a4a5893f4a2
https://pubmed.ncbi.nlm.nih.gov/34491039
https://pubmed.ncbi.nlm.nih.gov/34491039
Autor:
Hung-wen Liu, Mark W. Ruszczycky
Publikováno v:
Biochemistry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7253e2fdc4826674713698f50ec735
https://pubmed.ncbi.nlm.nih.gov/34096265
https://pubmed.ncbi.nlm.nih.gov/34096265
Publikováno v:
Journal of the American Chemical Society. 141:1062-1066
Hyoscyamine 6β-hydroxylase (H6H) is an αKG-dependent nonheme iron oxidase that catalyzes the oxidation of hyoscyamine to scopolamine via two separate reactions: hydroxylation followed by oxidative cyclization. Both of these reactions are expected t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::497b371e6f11a298a8a9f0f5b83900c3
https://doi.org/10.1021/jacs.8b11585
https://doi.org/10.1021/jacs.8b11585
Autor:
Daan, Ren, Mark W, Ruszczycky, Yeonjin, Ko, Shao-An, Wang, Yasushi, Ogasawara, Minje, Kim, Hung-Wen, Liu
Publikováno v:
Proc Natl Acad Sci U S A
Coformycin and pentostatin are structurally related N-nucleoside inhibitors of adenosine deaminase characterized by an unusual 1,3-diazepine nucleobase. Herein, the cof gene cluster responsible for coformycin biosynthesis is identified. Reconstitutio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5eab12d4c6e4f183ac2941c369b6d125
https://pubmed.ncbi.nlm.nih.gov/32350138
https://pubmed.ncbi.nlm.nih.gov/32350138
Publikováno v:
Biochemistry. 57:3130-3133
DesII is a radical SAM lyase that catalyzes a deamination reaction during the biosynthesis of desosamine in Streptomyces venezuelae. Competing mechanistic hypotheses for this radical-mediated reaction are differentiated according to whether or not a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::651ab0dc952d73b7b1e06cc75e5d5645
https://doi.org/10.1021/acs.biochem.8b00110
https://doi.org/10.1021/acs.biochem.8b00110