Výsledky vyhledávání - "Mark W, Albers"

Akademický článek

Tau propagation in the brain olfactory circuits is associated with smell perception changes in aging

Autor: Ibai Diez, Laura Ortiz-Terán, Thomas S. C. Ng, Mark W. Albers, Gad Marshall, William Orwig, Chan-mi Kim, Elisenda Bueichekú, Victor Montal, Jonas Olofsson, Patrizia Vannini, Georges El Fahkri, Reisa Sperling, Keith Johnson, Heidi I. L. Jacobs, Jorge Sepulcre

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract The direct access of olfactory afferents to memory-related cortical systems has inspired theories about the role of the olfactory pathways in the development of cortical neurodegeneration in Alzheimer’s disease (AD). In this study, we used

Externí odkaz: https://doaj.org/article/53baab9f774f44ed85ed879dfc0ad4b7

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Akademický článek

Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Previous observational studies of the diabetes drugs metformin vs. sulfonylureas have yielded mixed results about whether metformin reduces the risk of dementia, relative to the sulfonylureas. Here, the authors apply a novel competing risks approach

Externí odkaz: https://doaj.org/article/6c6653ae33484933bc4f68d1094c553c

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Akademický článek

Machine learning identifies candidates for drug repurposing in Alzheimer’s disease

Autor: Steve Rodriguez, Clemens Hug, Petar Todorov, Nienke Moret, Sarah A. Boswell, Kyle Evans, George Zhou, Nathan T. Johnson, Bradley T. Hyman, Peter K. Sorger, Mark W. Albers, Artem Sokolov

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Clinical trials of novel therapeutics for Alzheimer’s Disease (AD) have provided largely negative results, so far. Here, the authors present a machine learning framework that quantifies potential associations between the pathology of AD severity an

Externí odkaz: https://doaj.org/article/93e763bd3055417ea9c559a7b6fa24d5

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Olfactory Function and Markers of Brain Pathology in Non-Demented Individuals with Autosomal Dominant Alzheimer’s Disease

Autor: Liliana, Ramirez-Gomez, Mark W, Albers, Ana, Baena, Clara, Vila-Castelar, Joshua T, Fox-Fuller, Justin, Sanchez, Felipe, Jain, Alefiya D, Albers, Francisco, Lopera, Yakeel T, Quiroz

Publikováno v: J Alzheimers Dis

Background: Olfactory dysfunction is one of the earliest signs of Alzheimer’s disease (AD), highlighting its potential use as a biomarker for early detection. It has also been linked to progression from mild cognitive impairment (MCI) to dementia.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a085a66e3df20e05862c89236fbd460d
https://doi.org/10.3233/jad-220075

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Machine learning identifies candidates for drug repurposing in Alzheimer’s disease

Autor: Bradley T. Hyman, Nathan T. Johnson, Sarah A. Boswell, Mark W. Albers, Kyle Evans, George Zhou, Artem Sokolov, Clemens B. Hug, Steven Rodriguez, Peter K. Sorger, Nienke Moret, Petar Todorov

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications

Clinical trials of novel therapeutics for Alzheimer’s Disease (AD) have consumed a large amount of time and resources with largely negative results. Repurposing drugs already approved by the Food and Drug Administration (FDA) for another indication

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad68ff5f7983e8e48180f85eeb89cb1a
https://doaj.org/article/93e763bd3055417ea9c559a7b6fa24d5

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Genome-encoded cytoplasmic double-stranded RNAs, found in C9ORF72 ALS-FTD brain, propagate neuronal loss

Autor: Elena Ratti, Alexis C. Gomez, Mark W. Albers, Matthew P. Frosch, Isabel Costantino, Steven Rodriguez, Eric B. Benz, Asli Sahin, Peter K. Sorger, Hawra Al-Lawati, Michael E. Talkowski, Benjamin R. Schrank, Bradley T. Hyman, Darian Fard, Alefiya Dhilla Albers, Luxiang Cao, Kyle Evans, Merit Cudkowicz

Publikováno v: Science Translational Medicine. 13

Triggers of innate immune signaling in the CNS of patients with amyotrophic lateral sclerosis and frontotemporal degeneration (ALS/FTD) remain elusive. We report the presence of cytoplasmic double-stranded RNA (cdsRNA), an established trigger of inna

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39c61bb0ad66390111bef7b616096b04
https://doi.org/10.1126/scitranslmed.aaz4699

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Systematic in silico analysis of clinically tested drugs for reducing amyloid‐beta plaque accumulation in Alzheimer's disease

Autor: Bradley T. Hyman, Robert A. Rissman, Lore Gruenbaum, Mark W. Albers, Lin Lin, Raibatak Das, Douglas A. Lauffenburger, Hafiz Mohmmadabdul, Fei Hua, John M. Burke, Joshua F. Apgar, Lucia Wille, Kumpal Madrasi

Publikováno v: Wiley
Alzheimers Dement

Introduction Despite strong evidence linking amyloid beta (Aβ) to Alzheimer's disease, most clinical trials have shown no clinical efficacy for reasons that remain unclear. To understand why, we developed a quantitative systems pharmacology (QSP) mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2926739c0e07a09427f41ae948a13936
https://hdl.handle.net/1721.1/135639

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