Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Mark Verheul"'
Autor:
Eline J. M. Bertrums, Jurrian K. de Kanter, Lucca L. M. Derks, Mark Verheul, Laurianne Trabut, Markus J. van Roosmalen, Henrik Hasle, Evangelia Antoniou, Dirk Reinhardt, Michael N. Dworzak, Nora Mühlegger, Marry M. van den Heuvel-Eibrink, C. Michel Zwaan, Bianca F. Goemans, Ruben van Boxtel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Therapy-related myeloid neoplasms (t-MN) arise as a complication of chemo- and/or radiotherapy. Although t-MN can occur both in adult and childhood cancer survivors, the mechanisms driving therapy-related leukemogenesis likely vary across di
Externí odkaz:
https://doaj.org/article/133d1d021aba4ed18ed60a7266e30b7f
Autor:
Freek Manders, Arianne M. Brandsma, Jurrian de Kanter, Mark Verheul, Rurika Oka, Markus J. van Roosmalen, Bastiaan van der Roest, Arne van Hoeck, Edwin Cuppen, Ruben van Boxtel
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-18 (2022)
Abstract Background The collective of somatic mutations in a genome represents a record of mutational processes that have been operative in a cell. These processes can be investigated by extracting relevant mutational patterns from sequencing data. R
Externí odkaz:
https://doaj.org/article/2850a20877ff45f2957546fea6286f10
Autor:
Karlijn A.L. Hasaart, Freek Manders, Joske Ubels, Mark Verheul, Markus J. van Roosmalen, Niels M. Groenen, Rurika Oka, Ewart Kuijk, Susana M. Chuva de Sousa Lopes, Ruben van Boxtel
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103736- (2022)
Summary: Induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine, but genetic instability is a major concern. Embryonic pluripotent cells also accumulate mutations during early development, but how this relates to the muta
Externí odkaz:
https://doaj.org/article/35c1315d16594b4f92d948fe5e60d5cc
Autor:
Jos B Poell, Rick J van Haastert, Thijs de Gunst, Iman J Schultz, Willemijn M Gommans, Mark Verheul, Francesco Cerisoli, Andre A F L van Puijenbroek, Paula I van Noort, Gregoire P Prevost, Roel Q J Schaapveld, Edwin Cuppen
Publikováno v:
PLoS ONE, Vol 8, Iss 1 (2013)
[This corrects the article DOI: 10.1371/journal.pone.0043569.].
Externí odkaz:
https://doaj.org/article/809690cb2b36494aae39d53295789ec4
Autor:
Jos B Poell, Rick J van Haastert, Thijs de Gunst, Iman J Schultz, Willemijn M Gommans, Mark Verheul, Francesco Cerisoli, Andre A F L van Puijenbroek, Paula I van Noort, Gregoire P Prevost, Roel Q J Schaapveld, Edwin Cuppen
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43569 (2012)
Malignant melanoma is an aggressive form of skin cancer with poor prognosis. Despite improvements in awareness and prevention of this disease, its incidence is rapidly increasing. MicroRNAs (miRNAs) are a class of small RNA molecules that regulate ce
Externí odkaz:
https://doaj.org/article/d40c736567e848e5920930dd9625597e
Publikováno v:
PLoS Genetics, Vol 2, Iss 7, p e121 (2006)
Genetic variation in genomes is organized in haplotype blocks, and species-specific block structure is defined by differential contribution of population history effects in combination with mutation and recombination events. Haplotype maps characteri
Externí odkaz:
https://doaj.org/article/adf596bca2e04eb8bb044daa4420a1b4
Although modern life grows increasingly casual, in many sectors, protocol still reigns supreme. An Expert's Guide to International Protocol offers an overview of its associated practices, including those found within the context of diplomatic relatio
Although modern life grows increasingly casual, in many sectors, protocol still reigns supreme. An Expert's Guide to International Protocol offers an overview of its associated practices, including those found within the context of diplomatic relatio
Autor:
Ruben van Boxtel, Mirjam E. Belderbos, Joske Ubels, Freek Manders, Mark Verheul, Rurika Oka, Damon A. Hofman, Markus J. van Roosmalen, Eline J.M. Bertrums, Arianne M. Brandsma
Supplementary Table S1-10 providing details on study cohorts and sequencing results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::604bd120ff80da895a88fc9deab43276
https://doi.org/10.1158/2643-3230.22543153.v1
https://doi.org/10.1158/2643-3230.22543153.v1
Autor:
Ruben van Boxtel, Bianca F. Goemans, C. Michel Zwaan, Hester A. de Groot-Kruseman, Markus J. van Roosmalen, Rurika Oka, Marry M. van den Heuvel-Eibrink, Mark Verheul, Anaïs J.C.N. van Leeuwen, Arianne M. Brandsma, Jurrian K. de Kanter, Axel K.M. Rosendahl Huber, Eline J.M. Bertrums
Childhood cancer survivors are confronted with various chronic health conditions like therapy-related malignancies. However, it is unclear how exposure to chemotherapy contributes to the mutation burden and clonal composition of healthy tissues early
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f08e9ef66548e287e4204011bb36a9a
https://doi.org/10.1158/2159-8290.c.6549550
https://doi.org/10.1158/2159-8290.c.6549550