Výsledky vyhledávání - "Mark V. de Ruiter"

Protecting Encapsulin Nanoparticles with Cysteine-Knot Miniproteins

Autor: Robin Klem, Jeroen J. L. M. Cornelissen, Mark V. de Ruiter

Publikováno v: Molecular pharmaceutics, 15(8), 2991-2996. American Chemical Society

A big hurdle for the use of protein-based drugs is that they are easily degraded by proteases in the human body. In an attempt to solve this problem, we show the possibility to functionalize TM encapsulin nanoparticles with an mEETI-II knottin minipr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65118bf31a9b0563fea0272a0ea3d5b4
https://doi.org/10.1021/acs.molpharmaceut.8b00630

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CCMV-based enzymatic nanoreactors

Autor: Mark V. de Ruiter, Rindia M. Putri, Jeroen J. L. M. Cornelissen

Publikováno v: Methods in Molecular Biology ISBN: 9781493978069
Methods in Molecular Biology, 1776, 237-247

Protein-based nanoreactors are generated by encapsulating an enzyme inside the capsid of the cowpea chlorotic mottle virus (CCMV). Here, three different noncovalent methods are described to efficiently incorporate enzymes inside the capsid of these v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff74ed5bec8b3af210763e04761992a
http://www.scopus.com/inward/record.url?scp=85048209964&partnerID=8YFLogxK

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Nanoreactors via encapsulation of catalytic gold nanoparticles within cowpea chlorotic mottle virus protein cages

Autor: Aijie Liu, Jeroen J. L. M. Cornelissen, Mark V. de Ruiter, Stan J. Maassen

Publikováno v: Methods in Molecular Biology ISBN: 9781493978922
Methods in Molecular Biology, 1798, 1-9

Viral protein cage-based nanoreactors can be generated by encapsulation of catalytic metal nanoparticles within the capsid structure. In this method, coat proteins of the cowpea chlorotic mottle virus (CCMV) are used to sequester gold nanoparticles (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::689550d3fdd3f42594958e0192e9de96
http://www.scopus.com/inward/record.url?scp=85048186120&partnerID=8YFLogxK

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Assembling Enzymatic Cascade Pathways inside Virus-Based Nanocages Using Dual-Tasking Nucleic Acid Tags

Autor: José R. Castón, Melissa S. T. Koay, Jeroen J. L. M. Cornelissen, Mark V. de Ruiter, Daniel Luque, Rindia M. Putri, M. Brasch

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)
Journal of the American Chemical Society
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Journal of the American Chemical Society, 139(4), 1512-1519. American Chemical Society

The packaging of proteins into discrete compartments is an essential feature for cellular efficiency. Inspired by Nature, we harness virus-like assemblies as artificial nanocompartments for enzyme-catalyzed cascade reactions. Using the negative charg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf16514b47f8f92e00f8debcff375c6
https://doi.org/10.1021/jacs.6b10948

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Structural nanotechnology: three-dimensional cryo-EM and its use in the development of nanoplatforms for in vitro catalysis

Autor: Mark V. de Ruiter, Robin Klem, José R. Castón, Daniel Luque, Jeroen J. L. M. Cornelissen

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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The organization of enzymes into different subcellular compartments is essential for correct cell function. Protein-based cages are a relatively recently discovered subclass of structurally dynamic cellular compartments that can be mimicked in the la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763683f6aa61490eb0689808005cd836
https://pubmed.ncbi.nlm.nih.gov/30793729

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Oligonucleotide Length-Dependent Formation of Virus-Like Particles

Autor: Stan J. Maassen, Mark V. de Ruiter, Saskia Lindhoud, Jeroen J. L. M. Cornelissen

Publikováno v: Chemistry : a European journal, 24(29), 7456-7463. Wiley-VCH Verlag

Understanding the assembly pathway of viruses can contribute to creating monodisperse virus-based materials. In this study, the cowpea chlorotic mottle virus (CCMV) is used to determine the interactions between the capsid proteins of viruses and thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5929486d94ed5de428a3b1372958886
https://research.utwente.nl/en/publications/f59ede44-be9a-4025-b9aa-b851806d86c8

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Induced Förster resonance energy transfer by encapsulation of DNA-scaffold based probes inside a plant virus based protein cage

Autor: Gaurav Singhai, Jeroen J. L. M. Cornelissen, Mark V. de Ruiter, Nico J Overeem

Publikováno v: Journal of Physics Condensed Matter, 30(18):184002. IOP Publishing Ltd.
Journal of Physics

Insight into the assembly and disassembly of viruses can play a crucial role in developing cures for viral diseases. Specialized fluorescent probes can benefit the study of interactions within viruses, especially during cell studies. In this work, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::132f35d6093c71a2a0f8db254fb82042
https://research.utwente.nl/en/publications/69283263-f418-414a-9818-9118800c7629

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Compartmentalized supramolecular hydrogels based on viral nanocages towards sophisticated cargo administration

Autor: Jeroen J. L. M. Cornelissen, Nathalie Katsonis, Liulin Yang, Catharina A. Hommersom, Mark V. de Ruiter, Aijie Liu, Pascal Jonkheijm

Publikováno v: Nanoscale, 10(8), 4123-4129. Royal Society of Chemistry
Nanoscale

Introduction of compartments with defined spaces inside a hydrogel network brings unique features, such as high loading efficiency, cargo quantification, stabilization and diminishment of burst release.
Introduction of compartments with defined

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd6f650de78f7a5a1fc04c799594a387
https://research.utwente.nl/en/publications/f653c30d-4057-410e-a53e-b2effcbc6325

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Supramolecular Surface Immobilization of Knottin Derivatives for Dynamic Display of High Affinity Binders

Autor: Pascal Jonkheijm, Jeroen J. L. M. Cornelissen, Mark V. de Ruiter, Shrikrishnan Sankaran

Publikováno v: Bioconjugate chemistry, 26(9), 1972-1980. American Chemical Society

Knottins are known as a robust and versatile class of miniprotein scaffolds for the presentation of high-affinity binding peptides; however, to date their application in biomaterials, biological coatings, and surface applications have not been explor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c5d45527d2436bdcc5f36952a81ff06
https://doi.org/10.1021/acs.bioconjchem.5b00419

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Hierarchical pore structures as highways for enzymes and substrates

Autor: Mark V. de Ruiter, Jeroen J. L. M. Cornelissen, Jurriaan Huskens, Raquel Mejia-Ariza

Publikováno v: Chem, 1(1), 29-31. Elsevier

The use of enzymes in chemical reactions needs packaging inside a porous matrix. In this issue of Chem , Farha et al. show that a hierarchical metal-organic framework with large and small pores allows orthogonal access of enzymes and their substrates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc8757a12aebdd96e3a90b533c20c1c
https://doi.org/10.1016/j.chempr.2016.06.009

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