Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mark V. Whiting"'
Synthesis and pharmacological properties of BW315c and other inotropic 2-arylimidazo[1,2-a]pyrazines
Autor:
Robert Antony David Hull, P. Randall, James W. Black, S. J. Vine, Heather Giles, V. Paul Gerskowitch, David Cambridge, Ramachandran Iyer, Shah Gita Punjabhai, David Stone, Malcolm Stuart Nobbs, Mark V. Whiting, Robert C. Glen, W. Richard King, Paul Barraclough
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:509-514
A series of 2-aryl imidazo[1,2-a]pyrazines has been prepared and evaluated for inotropic activity. Sulphoxide 12, BW315C, displayed potent inotropic effects having comparable in vitro and vivo inotropic potencies to those of isomazole. Structure-acti
Autor:
James W. Black, Nobbs, Cox, D Firmin, R.A.D. Hull, Paul Barraclough, S. J. Vine, Mark V. Whiting, A. P. Hill, D. Kettle, Robert C. Glen, W. R. King, C. J. Wharton, Ramachandran Iyer, S. Smith, P. Randall, V.P. Gerskowitch, David Cambridge, E. Capon, Heather Giles, P. Skone
Publikováno v:
European Journal of Medicinal Chemistry. 27:207-217
A series of 2-arylimidazo[1,2- a ]pyrimidines has been prepared and evaluated for inotropic activity. Three of these heterocycles, ether 19 , sulphide 21 and mesylate 24 displayed more potent inotropic effects in vitro than isomazole. The in vivo ino
Autor:
V. Paul Gerskowitch, David Cambridge, Mark V. Whiting, Janet M. Gillam, Robert Antony David Hull, Paul Barraclough, Steven Smith, Shah Gita Punjabhai, Ramachandran Iyer, Heather Giles, P. Randall, Robert C. Glen, James W. Black, David Firmin
Publikováno v:
Archiv der Pharmazie. 325:225-234
Aryl substituted 1H-imidazo[1, 2-a]imidazole 8, imidazo[2,1-b]thiazole 9, 1,4-dihydroimidazo[4,5-d]imidazole 11, and 1(2),4-dihydroimidazo[4,5-c]pyrazoles 12–17 have been prepared. An X-ray crystallographic study confirmed the structure of 8 and sh
Autor:
James W. Black, D. Collard, R.A.D. Hull, Robert C. Glen, DA Demaine, D Firmin, P. Randall, Nobbs, G. Shah, Mark V. Whiting, Paul Barraclough, S. J. Vine, Ramachandran Iyer, A. P. Hill, W. R. King, David J. Livingstone, RM Beams, Heather Giles, V.P. Gerskowitch, David Cambridge
Publikováno v:
European Journal of Medicinal Chemistry. 25:467-477
Aryl-substituted benzimidazole, imidazopyridine, imidazopyrazine, imidazopyridazine, oxazolopyridine, purine, pyrollopyridine and thiazolopyridine derivatives have been prepared and evaluated as inotropic agents. Purine 8 and the 1 H -imidazo[4,5- c
Publikováno v:
European journal of pharmacology. 361(2-3)
The anti-migraine drug zolmitriptan is a novel 5-HT1B/1D receptor partial agonist which, unlike sumatriptan, has been shown to cross the intact blood-brain barrier. In this study we examined whether or not the ability to access the cerebro-vascular i
Autor:
G. Shah, R. Lyer, Mark V. Whiting, S. Smith, R.A.D. Hull, Malcolm Stuart Nobbs, W. R. King, James W. Black, Paul Barraclough, David Cambridge, V.P. Gerskowitch, C. O. Kneen, S. J. Vine
Publikováno v:
ChemInform. 21
Autor:
DA Demaine, R.A.D. Hull, R. Lyer, Mark V. Whiting, David J. Livingstone, P. Randall, Heather Giles, G. Shah, W. R. King, Malcolm Stuart Nobbs, Paul Barraclough, David Cambridge, V.P. Gerskowitch, A. P. Hill, James W. Black
Publikováno v:
ChemInform. 21
Autor:
Mark V. Whiting, James W. Black, Clare O. Kneen, S. J. Vine, V. Paul Gerskowitch, Ramachandran Lyer, Shah Gita Punjabhai, Paul Barraclough, Steven Smith, David Cambridge, Malcolm Stuart Nobbs, Robert Antony David Hull, W. Richard King
Publikováno v:
Archiv der Pharmazie. 323(8)
A series of 2-substituted 1H-imidazo[4,5-b]pyridines and the isomeric 1H-imidazo[4,5-c]pyridine derivatives has been prepared and evaluated as inotropic agents. The 1H-imidazo-[4,5-b] derivatives were found to be consistently more potent than their i
Autor:
Mark V. Whiting, James W. Black, Shah Gita Punjabhai, P. Randall, Robert Antony David Hull, David Cambridge, Malcolm Stuart Nobbs, Heather Giles, David J. Livingstone, Paul Barraclough, V. Paul Gerskowitch, W. Richard King, Alan Peter Hill, Ramachandran Lyer, Derek A. Demaine
Publikováno v:
Archiv der Pharmazie. 323(8)
Isomazole analogues which have achiral electron withdrawing substituents at the 4′-position and analogues with heterocyclic ‘C’ rings have been synthesized and evaluated as inotropic agents. It was found that pyridyl could replace phenyl in the
Autor:
Mark V. Whiting, David Cambridge
Publikováno v:
Cardiovascular research. 20(6)
The response of a simple systolic time interval, the interval between the Q wave and the onset of the aortic blood pressure pulse (the QA interval), to changes in cardiac contractility, cardiac loading, and heart rate was evaluated in anaesthetised o