Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mark Trocha"'
Autor:
Lisa A. Orband-Miller, Erkan Baloglu, Jianfei Yang, Ashley A. Barnes, Jill Skepner, Thaddeus J. Carlson, Darby Schmidt, Mark S. Sundrud, Shomir Ghosh, Mercedes Lobera, Jonathan Hill, Radha Ramesh, Mohamed Boudjelal, Mark Trocha
Publikováno v:
The Journal of Immunology. 192:2564-2575
IL-17–producing CD4+Th17 cells, CD8+Tc17 cells, and γδ T cells play critical roles in the pathogenesis of autoimmune psoriasis. RORγt is required for the differentiation of Th17 cells and expression of IL-17. In this article, we describe a novel
Autor:
Allison M. Martino, James L Ellis, Irina S. Zemtseva, Roseanne S. Wexler, Joseph D. Schroeder, Steward K Richardson, David R. Janero, L. Gordon Letts, Shiow-Jyi Wey, Madhavi G. Murty, Michael E. Augustyniak, William M. Selig, David S. Garvey, A. Mark Trocha, Brian M. Zifcak, Edward Cochran, Terry L. Melim, Delano V. Young, Xinqin Fang
Publikováno v:
Journal of Medicinal Chemistry. 50:6367-6382
Indomethacin, a nonselective cyclooxygenase (COX) inhibitor, was modified in three distinct regions in an attempt both to increase cyclooxygenase-2 (COX-2) selectivity and to enhance drug safety by covalent attachment of an organic nitrate moiety as
Autor:
A. Mark Trocha, David S. Garvey, Michael E. Augustyniak, Stewart K. Richardson, Mathew J. Shumway, David R. Janero, Delano V. Young, L. Gordon Letts, James L. Ellis, Ramani R. Ranatunge, Irina S. Zemtseva, Vijay Dhawan
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:2589-2599
A series of glycolamide naproxen prodrugs containing a nitrate group as a nitric oxide (NO) donor moiety has been synthesized. These compounds were evaluated for their anti-inflammatory activity, naproxen release, and gastric tolerance. Compounds 4a,
Autor:
David R. Janero, Ramani R. Ranatunge, Matthew J. Shumway, Delano V. Young, James L. Ellis, Joseph D. Schroeder, S. William Tam, David S. Garvey, A. Mark Trocha, L. Gordon Letts, Madhavi G. Murty, Michael E. Augustyniak, Richard A. Earl, Upul K. Bandarage, Allison M. Martino, Stewart K. Richardson
Publikováno v:
Journal of Medicinal Chemistry. 47:2180-2193
The synthesis of a series of novel pyrazoles containing a nitrate (ONO(2)) moiety as a nitric oxide (NO)-donor functionality is reported. Their COX-1 and COX-2 inhibitory activities in human whole blood are profiled. Our data demonstrate that pyrazol
In vivo regulation of gene expression and T helper type 17 differentiation by RORγt inverse agonists
Autor:
Jill Skepner, Erkan Baloglu, Jonathan Hill, Mark Trocha, Mark S. Sundrud, Xiaoyan Qu, Michael A. Nolan, Radha Ramesh, Jianfei Yang, Scott Davis, Shomir Ghosh, Thaddeus J. Carlson, Darby Schmidt, Mercedes Lobera
Publikováno v:
Immunology. 145(3)
The orphan nuclear receptor, retinoic acid receptor-related orphan nuclear receptor γt (RORγt), is required for the development and pathogenic function of interleukin-17A-secreting CD4(+) T helper type 17 (Th17) cells. Whereas small molecule RORγt
Autor:
Geoffrey Bessin, Mary Theresa Shore, Mark Trocha, Delia Wolf, Gerald L. Wolf, Jodwiga Rogowska, Kathleen R. Whiteman
Publikováno v:
Academic Radiology. 5:S127-S130
Publikováno v:
Journal of Clinical & Cellular Immunology.
Naive CD4+ T helper cells can differentiate into Th1, Th2, Th17, T regulatory, Th9 and Th22 cells. Th1 cells are characterized by their production of IFNγ but not IL-4 and IL-5 while Th2 cells are characterized by their expression of IL-4 and IL-5 b
Autor:
William M. Selig, Laura J. Gordon, Terry L. Melim, L. Gordon Letts, David J. Schwalb, Irina S. Zemtseva, David R. Janero, Delano V. Young, Michael E. Augustyniak, Edward Cochran, Richard A. Earl, Madhavi G. Murty, Subhash P. Khanapure, David S. Garvey, James L. Ellis, Matthew J. Shumway, A. Mark Trocha
Publikováno v:
Inflammopharmacology. 12(5-6)
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to treat inflammation and to provide pain relief but suffer from a major liability concerning their propensity to cause gastric damage. As nitric oxide (NO) is known to be gastro-protecti
Autor:
Przemyslaw A. Marek, David S. Garvey, L. Gordon Letts, Delano V. Young, Diana Serebryanik, Chia-En Lin, Matthew J. Shumway, Stewart K. Richardson, David R. Janero, A. Mark Trocha, S. William Tam
Publikováno v:
Journal of medicinal chemistry. 47(9)
The combination of a nitric oxide (NO) donor and a paclitaxel-NO donor conjugate coated on a vascular stent was tested in a rabbit iliac artery model of stenosis as a potential therapy for restenosis. Paclitaxel was conjugated with a NO donor at the
Autor:
Przemyslaw A. Marek, S. William Tam, Madhavi G. Murty, Maiko Ezawa, Mark Trocha, L. Gordon Letts, Richard A Earl, Rick D Gaston, Delano V. Young, Subhash P. Khanapure, Xinqin Fang, David S. Garvey, David R. Janero, Allison M. Martino, Matthew J. Shumway
Publikováno v:
Journal of medicinal chemistry. 46(25)
A novel series of benzo-1,3-dioxolane metharyl derivatives was synthesized and evaluated for cyclooxygenase-2 (COX-2) and cyclooxygenase-1 (COX-1) inhibition in human whole blood (HWB). In the present study, structure-activity relationships (SAR) in