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Improving the Gastrointestinal Tolerability of Fumaric Acid Esters: Early Findings on Gastrointestinal Events with Diroximel Fumarate in Patients with Relapsing-Remitting Multiple Sclerosis from the Phase 3, Open-Label EVOLVE-MS-1 Study

Autor: Catherine Miller, Natasha Penner, Richard Leigh-Pemberton, Kristopher Perkin, Angela Wehr, Mark Tawa, Michael J. Palte, Jerome Hanna

Publikováno v: Advances in Therapy

Introduction Diroximel fumarate (DRF) is a novel oral fumarate in development for patients with relapsing forms of multiple sclerosis (MS). Clinical findings from the DRF development program suggest that rates of gastrointestinal (GI) treatment-emerg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64eaa7c4a7490140a256f790dae1d74f
http://europepmc.org/articles/PMC6822793

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Celecoxib sodium salt: engineering crystal forms for performance

Autor: Orn Almarsson, Magali B. Hickey, Julius F. Remenar, Mark Tawa, Matthew Peterson, Bruce M. Foxman

Publikováno v: CrystEngComm. 13:1081-1089

Crystalline hydrates and propylene glycol solvates of celecoxib sodium salt (Cel-Na) were prepared and characterized with the aim of improving oral drug absorption by breaking up the H-bonding interactions present in crystals of the poorly soluble ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5694cb754ab9ac1fb05446d69871e320
https://doi.org/10.1039/c0ce00475h

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High-Throughput Surveys of Crystal Form Diversity of Highly Polymorphic Pharmaceutical Compounds

Autor: Mark Tawa, Stephen Soukasene, Julius F. Remenar, J. Michael Macphee, Matthew Peterson, Magali B. Hickey, Orn Almarsson, Sherry L. Morissette, Chris McNulty

Publikováno v: Crystal Growth & Design. 3:927-933

Surveys of crystal form diversity of two test compounds, 1 (an experimental angiotensin II antagonist) and 2 (sertraline HCl, the active drug in Zoloft), have been performed with high-throughput (HT) crystallization. Compound 1 was found to have at l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6dbb2e9f6b3a0478f7ce52be69ebc7d
https://doi.org/10.1021/cg034058b

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Combined use of crystalline salt forms and precipitation inhibitors to improve oral absorption of celecoxib from solid oral formulations

Autor: Paul E. Shaw, Zhong Zhang, Orn Almarsson, Julius F. Remenar, Pasut Ratanabanangkoon, Mark Tawa, Colin R. Gardner, Hongming Chen, Jean‐Pierre Moreau, Hector Guzman

Publikováno v: Journal of pharmaceutical sciences. 96(10)

Biopharmaceutical evaluation of crystalline celecoxib salts in novel solid formulations, which were designed to simultaneously facilitate dissolution and inhibit precipitation in vitro, showed fast and complete absorption in beagle dogs at doses up t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5c119fe9b931f2104d478f75d54a73a
https://pubmed.ncbi.nlm.nih.gov/17518357

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Performance comparison of a co-crystal of carbamazepine with marketed product

Autor: Mark Tawa, Michael J. Zaworotko, Anna Vetter, Sean Haley, Lisa Scoppettuolo, Matthew Peterson, Julius F. Remenar, Hector Guzman, Sherry L Morrisette, Orn Almarsson, Zhong Zhang, Magali B. Hickey

Publikováno v: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 67(1)

The carbamazepine: saccharin co-crystal (1) was studied in terms of a series of attributes, including suitability for multi-gram scale-up, propensity for crystal polymorphism, physical stability, in vitro dissolution and oral bioavailability, with th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500edd974c0b6cf717e135a812c7ad66
https://pubmed.ncbi.nlm.nih.gov/17292592

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